Patents by Inventor Darrin Anthony Lindhout

Darrin Anthony Lindhout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Using Compositions Comprising Variants and Fusions of FGF19 Polypeptides for Treatment of Metabolic Disorders and Diseases
    Publication number: 20240050530
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: August 21, 2023
    Publication date: February 15, 2024
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20230312696
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: November 7, 2022
    Publication date: October 5, 2023
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • MODIFIED VIRAL COMPOSITIONS FOR VIRAL TRANSDUCTION
    Publication number: 20230279426
    Abstract: This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a modified viral composition that includes a moiety that binds to a cell surface receptor ligand. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy. Also provided are pharmaceutical compositions and kits including a modified viral composition.
    Type: Application
    Filed: June 24, 2021
    Publication date: September 7, 2023
    Inventors: Tigran Arvid AIVAZIAN, Richard James GLYNNE, Dallas Clifford JONES, Stephanie Ann PINKERTON, Darrin Anthony LINDHOUT, Sarah M. MCWHIRTER
  • BIFUNCTIONAL BRIDGING COMPOSITIONS FOR VIRAL TRANSDUCTION
    Publication number: 20230226214
    Abstract: This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a bifunctional bridging composition that includes a moiety that binds to a cell surface receptor ligand and a linked bridging moiety that binds to a viral composition. Also provided are modified viral compositions comprising a bridging composition specifically bound via its bridging moiety to the viral composition. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy.
    Type: Application
    Filed: June 24, 2021
    Publication date: July 20, 2023
    Inventors: Tigran Arvid AIVAZIAN, Richard James GLYNNE, Dallas Clifford JONES, Stephanie Ann PINKERTON, Darrin Anthony LINDHOUT, Sarah M. MCWHIRTER, Richard G. YAU
  • Compositions and methods of use for treating metabolic disorders
    Patent number: 11530260
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: December 20, 2022
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Compositions and methods of use for treating metabolic disorders
    Patent number: 11358995
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: June 14, 2022
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Darrin Anthony Lindhout, Raj Haldankar, Hui Tian, Jer-Yuan Hsu
  • Methods of Using Compositions Comprising Variants and Fusions of FGF19 Polypeptides for Treatment of Metabolic Disorders and Diseases
    Publication number: 20220088140
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: June 23, 2021
    Publication date: March 24, 2022
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • PHARMACEUTICAL COMPOSITIONS COMPRISING PEPTIDE VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20220047675
    Abstract: Provided herein are pharmaceutical compositions, formulations and dosage forms comprising variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). Methods of using the pharmaceutical compositions, formulations and dosage forms are also provided herein.
    Type: Application
    Filed: June 22, 2021
    Publication date: February 17, 2022
    Inventors: Darrin Anthony Lindhout, Charles V. Olson
  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20210388047
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 16, 2021
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar, Geoffrey Horner
  • Compositions comprising fusion variants of FGF19 polypeptides
    Patent number: 11065302
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: July 20, 2021
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions comprising variants and fusions of FGF19 polypeptides
    Patent number: 11066454
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: July 20, 2021
    Assignee: NGM BIOPHARMACEUTICALS, INC.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions and Methods for Treatment of Metabolic Disorders and Diseases
    Publication number: 20210169983
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: August 10, 2020
    Publication date: June 10, 2021
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions and methods of use for treating metabolic disorders
    Patent number: 10869909
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: December 22, 2020
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Darrin Anthony Lindhout, Peng Zhang, Thomas Frederick Parsons
  • Methods of using compositions comprising variants and fusions of FGF 19 polypeptides for treating diabetes
    Patent number: 10758590
    Abstract: The invention relates to methods of using variants and fusions of fibroblast growth factor 19 (FGF19) for treating diabetes.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: September 1, 2020
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • PHARMACEUTICAL COMPOSITIONS COMPRISING PEPTIDE VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20200197490
    Abstract: Provided herein are pharmaceutical compositions, formulations and dosage forms comprising variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). Methods of using the pharmaceutical compositions, formulations and dosage forms are also provided herein.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 25, 2020
    Inventors: Darrin Anthony Lindhout, Charles V. Olson
  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20200165314
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 28, 2020
    Inventors: Darrin Anthony Lindhout, Raj Haldankar, Hui Tian, Jer-Yuan Hsu
  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20200140536
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 7, 2020
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Compositions and methods of use for treating metabolic disorders
    Patent number: 10610568
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 7, 2020
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar
  • Compositions and Methods of Use For Treating Metabolic Disorders
    Publication number: 20200087366
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: April 29, 2019
    Publication date: March 19, 2020
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar, Geoffrey Horner
  • Methods and Compositions for the Treatment of Metabolic Disorders and Diseases
    Publication number: 20200054714
    Abstract: Provided herein are variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: August 6, 2019
    Publication date: February 20, 2020
    Inventors: Lei Ling, Darrin Anthony Lindhout