Patents by Inventor Darrin Anthony Lindhout

Darrin Anthony Lindhout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20170246249
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: December 13, 2016
    Publication date: August 31, 2017
    Inventors: Darrin Anthony Lindhout, Peng Zhang, Thomas Frederick Parsons
  • PHARMACEUTICAL COMPOSITIONS COMPRISING PEPTIDE VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20170232067
    Abstract: Provided herein are pharmaceutical compositions, formulations and dosage forms comprising variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). Methods of using the pharmaceutical compositions, formulations and dosage forms are also provided herein.
    Type: Application
    Filed: October 22, 2015
    Publication date: August 17, 2017
    Inventors: Darrin Anthony LINDHOUT, Charles V. OLSON
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND DISEASES
    Publication number: 20170182122
    Abstract: Provided herein are variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: May 27, 2015
    Publication date: June 29, 2017
    Inventors: Lei LING, Darrin Anthony LINDHOUT
  • Compositions comprising fusion variants of FGF19 polypeptides
    Patent number: 9670260
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: June 6, 2017
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of diabetes
    Patent number: 9580483
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: February 28, 2017
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions and methods of use for treating metabolic disorders
    Patent number: 9550819
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: January 24, 2017
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Darrin Anthony Lindhout, Peng Zhang, Thomas Frederick Parsons
  • COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
    Publication number: 20160200787
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 14, 2016
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar, Geoffrey Horner
  • COMPOSITIONS, USES AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES
    Publication number: 20160200788
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: December 30, 2015
    Publication date: July 14, 2016
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • COMPOSITIONS COMPRISING VARIANTS AND FUSIONS OF FGF19 POLYPEPTIDES
    Publication number: 20160168215
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: December 29, 2015
    Publication date: June 16, 2016
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • METHODS OF USING COMPOSITIONS COMPRISING VARIANTS AND FUSIONS OF FGF19 POLYPEPTIDES FOR REDUCING GLUCOSE LEVELS IN A SUBJECT
    Publication number: 20160168216
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: December 29, 2015
    Publication date: June 16, 2016
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
    Publication number: 20160129082
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: September 4, 2015
    Publication date: May 12, 2016
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar
  • COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
    Publication number: 20160120999
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 5, 2016
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Compositions comprising variants and fusions of FGF19 polypeptides
    Patent number: 9290557
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: March 22, 2016
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
    Publication number: 20160031960
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: July 28, 2015
    Publication date: February 4, 2016
    Inventors: Darrin Anthony Lindhout, Raj Haldankar, Hui Tian, Jer-Yuan Hsu
  • GDF15 mutein polypeptides
    Patent number: 9161966
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: October 20, 2015
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar
  • COMPOSITIONS AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES
    Publication number: 20150291677
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 15, 2015
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • METHODS OF USING COMPOSITIONS COMPRISING VARIANTS AND FUSIONS OF FGF19 POLYPEPTIDES FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES
    Publication number: 20150284442
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Application
    Filed: June 18, 2015
    Publication date: October 8, 2015
    Inventors: Lei LING, Darrin Anthony LINDHOUT
  • Methods of using compositions comprising variants and fusions of FGF19 polypeptides for reducing glucose levels in a subject
    Patent number: 9089525
    Abstract: The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: July 28, 2015
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Lei Ling, Darrin Anthony Lindhout
  • Compositions and Methods of Use for Treating Metabolic Disorders
    Publication number: 20150023960
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 22, 2015
    Inventors: Darrin Anthony Lindhout, Peng Zhang, Thomas Frederick Parsons
  • COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
    Publication number: 20140213511
    Abstract: Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 31, 2014
    Inventors: Hugo Matern, Darrin Anthony Lindhout, Raj Haldankar