Abstract: A method of conveying a production fluid from an offshore subsea well to an offshore vessel includes deploying an inflatable bladder from the offshore vessel, the inflatable bladder including a bladder valve, and fluidly connecting the inflatable bladder to an offloading port positioned at a seafloor, wherein the offloading port includes a port valve and is in fluid communication with one or more subterranean hydrocarbon-bearing formations. The method further includes opening the bladder and port valves to discharge the production fluid from the offloading port into the inflatable bladder, and thereby resulting in a substantially filled bladder, closing the bladder and port valves, and fluidly disconnecting the substantially filled bladder from the offloading port.

Abstract: A lawn mower may include a blade housing configured to house at least a first blade and a second blade, a shaft disposed to rotate within the blade housing, a powerhead configured to selectively turn the shaft responsive to application of power from a power source, and a blade coupler configured to selectively couple the first blade and/or the second blade to the shaft to produce different cutting performance conditions based on which of the first blade and/or the second blade is operably coupled to the shaft.

Abstract: Techniques are described in which sensor data is used to determine one or more of background noise or occupancy associated with a passenger cabin of a vehicle. The sensor data, in turn, is used to determine an operating state for one or more components of the vehicle (e.g., pumps, compressors, fans, blowers, etc.) such that an amount of background noise within the passenger cabin is reduced (e.g., when a passenger/occupant is present). In various examples, the operating state of the component may operate in a different, though louder, state (e.g., higher efficiency, greater power, etc.) when an occupant is not present or proximate the component.

Abstract: A system for deploying an implant cut from a biological tissue into an eye of a patient including a delivery device and a nose cone assembly, a tubular shaft projecting from the distal end region of the nose cone and comprising a lumen. Related devices, systems, and methods are provided.

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 ammo acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.

Abstract: Systems and methods cause a component of a vehicle to activate. The systems and methods receive audio data generated by a microphone of the vehicle, where the audio data represents sound of the component. Based on the audio data, a condition of the vehicle or the component may be determined, and based on the condition, the vehicle may be commissioned for use or decommissioned.

Abstract: A riding lawn care vehicle may include a frame, a steering assembly, caster wheels and a drive assembly. At least a first drive wheel and a second drive wheel of the riding lawn care vehicle are attachable to the frame. The steering assembly is configured to facilitate turning of the riding lawn care vehicle based on drive speed control of the first and second drive wheels. The caster wheels are configured to support unpowered rotation about a wheel axis that extends substantially parallel to the ground and rotation about a spindle axis that is substantially perpendicular to the ground. The drive assembly is configured to be selectively placed in a disengaged state in which rotation about the spindle axis and the wheel axis is uninhibited, and an engaged state in which the caster wheels are at least partially inhibited with respect to rotation about both the wheel axis and the spindle axis.

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

Abstract: Alpha(v) beta (6) integrin (avb6) binding polypeptides are disclosed herein, and their use in treating and detecting tumors, and their use in treating pulmonary fibrosis.

Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQFQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

Abstract: Disclosed am protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called die key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co-localized when bound to their targets, components of such protein switches, and their use.

Abstract: A method of conveying a production fluid from an offshore subsea well to an offshore vessel includes deploying an inflatable bladder from the offshore vessel, the inflatable bladder including a bladder valve, and fluidly connecting the inflatable bladder to an offloading port positioned at a seafloor, wherein the offloading port includes a port valve and is in fluid communication with one or more subterranean hydrocarbon-bearing formations. The method further includes opening the bladder and port valves to discharge the production fluid from the offloading port into the inflatable bladder, and thereby resulting in a substantially filled bladder, closing the bladder and port valves, and fluidly disconnecting the substantially filled bladder from the offloading port.

Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?cheterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.

Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.

Abstract: The present disclosure provides a chimeric polypeptide comprising a helical bundle which comprises between about two and about seven alpha-helices and a bioactive peptide, wherein one or more of the alpha helices form one or more inter-helix hydrogen bonds and comprise at least one phosphorylation site and wherein the bioactive peptide is conformationally placed inside the helical bundle so that the bioactive peptide is not activated or exposed. The disclosure also provides a nucleotide sequence encoding the chimeric polypeptide, a vector comprising the nucleotide sequence, a cell comprising the nucleotide sequence, and method of making, using, or designing the chimeric polypeptide.

Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use.

Abstract: The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers.