Patents by Inventor David A. Baker

David A. Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WNT SIGNALING AGONIST MOLECULES
    Publication number: 20210403578
    Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Inventors: Kenan Christopher Garcia, David Baker, Claudia Yvonne Janda, Luke Dang, James Daniel Moody
  • SELF-ASSEMBLING PROTEIN STRUCTURES AND COMPONENTS THEREOF
    Publication number: 20210380641
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: November 9, 2018
    Publication date: December 9, 2021
    Inventors: Gabriel BUTTERFIELD, Marc Joseph LAJOIE, Neil P. KING, David BAKER, Daniel ELLIS
  • Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
    Patent number: 11192926
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 7, 2021
    Assignees: University of Washington, Institute for Research in Biomedicine
    Inventors: Neil P. King, David Baker, Brooke Nickerson, Lance Joseph Stewart, Laurent Perez, Antonio Lanzavecchia, Jessica Marcandalli
  • Transmembrane polypeptides
    Publication number: 20210363214
    Abstract: De novo designed multi-pass transmembrane polypeptides are described, that include 2 or more transmembrane domains that are each between 15 and 35 amino acids in length, include one or more polar residues, and include at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, or more hydrophobic amino acid residues.
    Type: Application
    Filed: February 28, 2019
    Publication date: November 25, 2021
    Inventors: Peilong LU, David BAKER, Scott BOYKEN, Zibo CHEN, Jorge FALLAS, George UEDA, William H. SHEFFLER
  • ORTHOGONAL PROTEIN HETERODIMERS
    Publication number: 20210355175
    Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
    Type: Application
    Filed: November 4, 2019
    Publication date: November 18, 2021
    Inventors: Zibo CHEN, Scott BOYKEN, Sherry BERMEO, Robert A. LANGAN, David BAKER
  • Polypeptide Assemblies and Methods for the Production Thereof
    Publication number: 20210340519
    Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.
    Type: Application
    Filed: June 2, 2021
    Publication date: November 4, 2021
    Inventors: Neil KING, Wesley SUNDQUIST, Joerg VOTTELER, Yang HSIA, David BAKER, Jacob BALE, Marc LAJOIE, Gabriel BUTTERFIELD, Elizabeth GRAY, Daniel STETSON
  • USING SOUND TO DETERMINE VEHICLE HEALTH
    Publication number: 20210335064
    Abstract: Systems and methods cause a component of a vehicle to activate. The systems and methods receive audio data generated by a microphone of the vehicle, where the audio data represents sound of the component. Based on the audio data, a condition of the vehicle or the component may be determined, and based on the condition, the vehicle may be commissioned for use or decommissioned.
    Type: Application
    Filed: May 3, 2021
    Publication date: October 28, 2021
    Inventors: Nicholas Nakjoo Kim, Daniel David Baker
  • SELF-ASSEMBLING PROTEIN HOMO-POLYMERS
    Publication number: 20210324011
    Abstract: Disclosed herein are polypeptides having the amino acid sequence that is at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the full length of the amino acid sequence selected from the group consisting of SEQ ID NO: 1-33 and 36, wherein the polypeptides include at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the identified interface residues, and wherein the polypeptides are capable of end-to-end homo-polymerization, homo-polymers of the polypeptides, and related capping and anchor proteins to facilitate homo-polymer formation.
    Type: Application
    Filed: October 24, 2019
    Publication date: October 21, 2021
    Inventors: Hao SHEN, Jorge FALLAS, David BAKER
  • FRIZZLED SPECIFIC WNT AGONISTS AND ANTAGONISTS
    Publication number: 20210317413
    Abstract: Wnt signaling antagonist and agonist compositions and methods for their use are provided.
    Type: Application
    Filed: July 15, 2019
    Publication date: October 14, 2021
    Inventors: Kenan Christopher Garcia, Yi Miao, David Baker, Keunwan Park, Luke Dang
  • WNT signaling agonist molecules
    Patent number: 11142577
    Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 12, 2021
    Assignees: The Board of Trustees of the Leland Stanford Junior University, University of Washington
    Inventors: Kenan Christopher Garcia, David Baker, Claudia Yvonne Janda, Luke Dang, James Daniel Moody
  • High throughput protein-protein interaction screening in yeast liquid culture
    Patent number: 11136573
    Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: October 5, 2021
    Assignee: University of Washington
    Inventors: David Baker, David Younger, Eric Klavins
  • FOLDED AND PROTEASE-RESISTANT POLYPEPTIDES
    Publication number: 20210284695
    Abstract: Non-naturally occurring polypeptides are disclosed that include (a) 3-3 secondary structure elements, wherein each secondary structure element is either an ?-helix (H domain) of between 10-20 amino acid residues in length or a ?-strand (E domain) of between 3-10 amino acid residues in length; and (b) 2-4 linkers of between 2 to 6 amino acid residues in length connecting adjacent secondary structure elements; wherein the polypeptide is between 25-50 amino acid residues in length; and wherein the polypeptide includes no cysteine residues.
    Type: Application
    Filed: April 27, 2018
    Publication date: September 16, 2021
    Inventors: Gabriel Jacob ROCKLIN, David BAKER
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11117944
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: September 14, 2021
    Assignees: University Of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Brian Weitzner
  • Compositions and Methods for Treating Celiac Sprue Disease
    Publication number: 20210246437
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Application
    Filed: April 14, 2021
    Publication date: August 12, 2021
    Inventors: Justin Bloomfield SIEGEL, David BAKER, Ingrid Swanson PULTZ
  • Computational Design of Self-Assembling Cyclic Protein Homo-oligomers
    Publication number: 20210183465
    Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.
    Type: Application
    Filed: September 22, 2020
    Publication date: June 17, 2021
    Inventors: David Baker, Jorge Fallas, George Ueda, William H. Sheffler, Vanessa Nguyen
  • COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE
    Publication number: 20210171928
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQFQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Application
    Filed: September 14, 2020
    Publication date: June 10, 2021
    Inventors: Ingrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
  • Polypeptide assemblies and methods for the production thereof
    Patent number: 11028383
    Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: June 8, 2021
    Assignees: University of Washington, University of Utah Research Foundation
    Inventors: Neil King, Wesley Sundquist, Joerg Votteler, Yang Hsia, David Baker, Jacob Bale, Marc Lajoie, Gabriel Butterfield, Elizabeth Gray, Daniel Stetson
  • Compositions and methods for treating celiac sprue disease
    Patent number: 11008558
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: May 18, 2021
    Assignee: University of Washington
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • Hyperstable Constrained Peptides and Their Design
    Publication number: 20210134388
    Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.
    Type: Application
    Filed: November 12, 2020
    Publication date: May 6, 2021
    Inventors: David BAKER, Christopher BAHL, Jason GILMORE, Gaurav BHARDWAJ, Vikram K. MULLIGAN, Peta HARVEY, Olivier CHENEVAL, David CRAIK
  • Speaker
    Patent number: D919599
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: May 18, 2021
    Assignee: Logitech Europe S.A.
    Inventors: Wenwei Wang, Ming-Hsiang Weng, Jeremy David Baker, Olivier Gregoire