Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: A handheld vacuum device is presented. That handheld vacuum device comprises a housing, a vacuum-generating system, and a hook. The housing has a handle, while the vacuum-generating system is disposed within the housing, and is configured to generate vacuum pressure that creates suction for the handheld vacuum device. The hook is coupled to the housing, and has a bent portion that is configured to engage an external structure for hanging the handheld vacuum device from the external structure.

Abstract: Systems and methods for generation and use of document analysis architectures are disclosed. A model builder component may be utilized to receiving user input data for labeling a set of documents as in class or out of class. That user input data may be utilized to train one or more classification models, which may then be utilized to predict classification of other documents. Trained models may be incorporated into a model taxonomy for searching and use by other users for document analysis purposes.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.

Abstract: A structured data store service, such as a database service, may implement fine-grained access to data maintained at the database service using federated identity. Fine grained access requests may be received at a database service for specified data maintained for an application provider from a client of the application provider. An access credential may be also be received. Verification of the access credential may be obtained, and the database service may evaluate the fine-grained access request according to a delegation policy corresponding to the access credential to determine whether the fine-grained request is authorized. If authorized, the fine-grained access request may be service. If not authorized, the fine-grained access request may be denied. In some embodiments, multiple application clients may have the same authorization for data, such as read authorization, while another one or more application clients may have different authorization for the data, such as write authorization.

Abstract: A system that provides services to clients may receive and service requests, various ones of which may require different amounts of work. The system may determine whether it is operating in an overloaded or underloaded state based on a current work throughput rate, a target work throughput rate, a maximum request rate, or an actual request rate, and may dynamically adjust the maximum request rate in response. For example, if the maximum request rate is being exceeded, the maximum request rate may be raised or lowered, dependent on the current work throughput rate. If the target or committed work throughput rate is being exceeded, but the maximum request rate is not being exceeded, a lower maximum request rate may be proposed. Adjustments to the maximum request rate may be made using multiple incremental adjustments. Service request tokens may be added to a leaky token bucket at the maximum request rate.

Abstract: This application relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and medical uses thereof.

Abstract: Disclosed herein are immunogenic compositions (e.g., vaccines) and methods of using and preparing the same. In some embodiments, the immunogenic compositions are suitable for use in treating or preventing an infectious disease, such as SARS-CoV-2 or HIV.

Abstract: A system and method for feeding a high volume of low-bulk-density and pressure-sensitive feedstocks into a pressurized environment. The system includes a lock hopper filling system, one or more lock hoppers, a feed bin, and a feeder. The methods involve using such a system to feed bulk materials into a pressurized environment by feeding bulk material from a low pressure into the surge bin, filling the one or more lock hoppers from the surge bin, operating the lock hoppers, and discharging lock hoppers into feed bin, and discharging feed bin into the high-pressure zone using feeder.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.

Abstract: Embodiments disclosed herein include an electronic package. In an embodiment, the electronic package comprises a package substrate having a first surface and a second surface opposite from the first surface, and a die on the first surface of the package substrate. In an embodiment, the electronic package further comprises a socket interface on the second surface of the package substrate. In an embodiment, the socket interface comprises a first layer, wherein the first layer comprises a plurality of wells, a liquid metal within the plurality of wells, and a second layer over the plurality of wells.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

Abstract: Systems and methods are provided for interpreting traffic information. A method includes: receiving, by a processor, visual data from vehicles, wherein the visual data is associated with an intersection of a roadway having one or more lanes; receiving, by the processor, vehicle data from the vehicles, wherein the vehicle data is associated with the intersection of the roadway; determining, by the processor, a first state of a traffic light associated with the intersection based on the visual data; determining, by the processor, a second state of the traffic light associated with the intersection based on the vehicle data; correlating, by the processor, the first state and the second state based on a time synchronization; assigning, by the processor, the traffic light to a lane of the roadway based on the correlating; and communicating, by the processor, the traffic light to lane assignment for use in controlling a vehicle.

Abstract: Embodiments disclosed herein include an electronic package. In an embodiment, the electronic package comprises a package substrate having a first surface and a second surface opposite from the first surface, and a die on the first surface of the package substrate. In an embodiment, the electronic package further comprises a socket interface on the second surface of the package substrate. In an embodiment, the socket interface comprises a first layer, wherein the first layer comprises a plurality of wells, a liquid metal within the plurality of wells, and a second layer over the plurality of wells.

Abstract: Systems and methods for generation and use of intellectual-property (IP) analysis platform architectures are disclosed. A scoring component may be utilized to produce scores for IP assets using user seeded searches in varying areas of interest, such as, for example, target technical fields, targeted publications, targeted products, and/or competitor entity portfolios. The scoring component may be further utilized to produce an interactive graphical element including a spatial representation of the scoring of IP assets. The interactive graphical element may include various functionalities and/or information associated with the of IP assets. The scoring component may utilize data from a coverage component, an opportunity component and/or an exposure component to assess a comprehensive score associated with a group of IP assets of a targeted entity.

Abstract: Systems and methods for generation and use of intellectual-property (IP) analysis platform architectures are disclosed. A scoring component may be utilized to produce scores for IP assets using user seeded searches in varying areas of interest, such as, for example, target technical fields, targeted publications, targeted products, and/or competitor entity portfolios. The scoring component may be further utilized to produce an interactive graphical element including a spatial representation of the scoring of IP assets. The interactive graphical element may include various functionalities and/or information associated with the of IP assets. The scoring component may utilize data from a coverage component, an opportunity component and/or an exposure component to assess a comprehensive score associated with a group of IP assets of a targeted entity.

Abstract: This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy.

Abstract: A system that provides services to clients may receive and service requests, various ones of which may require different amounts of work. The system may determine whether it is operating in an overloaded or underloaded state based on a current work throughput rate, a target work throughput rate, a maximum request rate, or an actual request rate, and may dynamically adjust the maximum request rate in response. For example, if the maximum request rate is being exceeded, the maximum request rate may be raised or lowered, dependent on the current work throughput rate. If the target or committed work throughput rate is being exceeded, but the maximum request rate is not being exceeded, a lower maximum request rate may be proposed. Adjustments to the maximum request rate may be made using multiple incremental adjustments. Service request tokens may be added to a leaky token bucket at the maximum request rate.

Abstract: Technologies are provided for acquisition of an item or service based on a directed content campaign. Embodiments include a computing system that can detect selection of directed content presented at a user device. The directed content identifies a mobile application and an action that results in the item being granted. After installation of the mobile application, the computing system can receive a device identifier of the user device in response to execution of the mobile application. The computing system can then generate data identifying events within the mobile application. The computing system can determine, using the user activity data, that a particular one of those events corresponds to the action, and can then generate a message that identifies the action and the item or service. The message also includes address data for a user interface to obtain the item or service. The computing system can then cause the user device to present the message.