Abstract: Technology is described for providing preconfigured device representations in a service provider environment. A plurality of device representation parameters may be received for a device via a user account. A preconfigured device representation may be created for the device using the plurality of device representation parameters. The preconfigured device representation may be associated with the user account. The device may be registered with the service provider environment. A registration of the device may be performed when the device initially connects to the service provider environment. The registration may assign a device identifier to the device and may associate the user account with the device. The preconfigured device representation may be provided to the device after the registration of the device is completed.

Abstract: Disclosed are methods and systems for high-throughput testing of pathogens, and in some instances, testing for SARS-CoV-2. For example, disclosed is a method for intelligently selecting samples to perform a pooled testing for a pathogen including the steps of obtaining samples from multiple regions/populations, determining a prevalence of the pathogen in the samples from each region/population, determining an optimal selection plan to perform the pooled testing, selecting and combining samples based on the optimal selection plan, aliquoting the samples in the combined sample set based on the optimal selection plan, pooling and testing the samples in the combined sample set based on the optimal pooling design to determine a presence or absence of a detectable amount of the pathogen in each of the pooled samples, and determining whether at least one individual sample comprises the detectable amount of the pathogen.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.

Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: This invention relates to dihydropyranopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Abstract: Embodiments disclosed herein include an electronic package. In an embodiment, the electronic package comprises a package substrate having a first surface and a second surface opposite from the first surface, and a die on the first surface of the package substrate. In an embodiment, the electronic package further comprises a socket interface on the second surface of the package substrate. In an embodiment, the socket interface comprises a first layer, wherein the first layer comprises a plurality of wells, a liquid metal within the plurality of wells, and a second layer over the plurality of wells.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.

Abstract: In general, embodiments of the invention relates to methods and systems generating accessible user interfaces or graphical user interfaces. More specifically, embodiments of the invention are directed to user interfaces that display data using combinations of graphical and non-graphical cells. The graphical cells may include both a graphical component as well as a data value component, where these components do not overlap within the cell. In this manner, embodiments of the invention may provide an additional layer of accessibility and interpretability of the data values in the graphical cells.

Abstract: A controlling device scans a label of a network-connected device to obtain a first set of information from a primary layer of the label, where the first set of information is about the network-connected device. The controlling device scans the label to obtain a second set of information from a secondary layer of the label, whereby the secondary layer is distinct from the primary layer. The controlling device transmits a request to a device server associated with the network-connected device to obtain device records for the device, whereby the request includes the second set of information. In response to the request, the controlling device receives the one or more device records.

Abstract: A system that provides services to clients may receive and service requests, various ones of which may require different amounts of work. The system may determine whether it is operating in an overloaded or underloaded state based on a current work throughput rate, a target work throughput rate, a maximum request rate, or an actual request rate, and may dynamically adjust the maximum request rate in response. For example, if the maximum request rate is being exceeded, the maximum request rate may be raised or lowered, dependent on the current work throughput rate. If the target or committed work throughput rate is being exceeded, but the maximum request rate is not being exceeded, a lower maximum request rate may be proposed. Adjustments to the maximum request rate may be made using multiple incremental adjustments. Service request tokens may be added to a leaky token bucket at the maximum request rate.

Abstract: A system for correcting HD map images is provided. The system is configured to: receive, from a plurality of vehicles, ground view image data of a map anomaly hotspot captured by the vehicles; convert the ground view image data to bird view image data using homography; remove outliers from the bird view image data; apply an error reduction algorithm; stitch together a sequence of consecutive images from the image data after error reduction to produce a high-definition image, wherein each of the consecutive images has been generated through converting ground view image data to bird view image data using homography, removing outliers from the bird view image data, and applying an error reduction algorithm; compare the stitched sequence of consecutive images to a high-definition image of the hotspot to determine revisions to the high-definition image; and provide revised high-definition image data for use in navigating near the map anomaly hotspot.

Abstract: A system, method, and non-transitory computer readable medium are provided for tuning sensitivities of, and determining a process window for, a modulated wafer. The sensitivities for dies of the modulated wafer are tuned dynamically based on a single set of parameters. Further, the process window is determined for the modulated wafer from prior determined parameter-specific nominal process windows.

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Abstract: A technology is described for modifying a message frequency of a device. In one example, a network connection is identified between a device and a service provider environment. A message frequency is set for which to send reachability messages between the device and the service provider environment to maintain the network connection. The reachability messages may be sent between the device and the service provider environment at the message frequency. After testing whether the networking connection is maintained at the message frequency, the message frequency may be modified to a modified message frequency.

Abstract: The present invention relates to topical formulations that include lipid microcapsules formed from tocopherol, tocotrienol, or mixtures thereof; a stabilizer/surfactant component; and an aqueous component. The lipid microcapsules may be formed without the use of steroids, preservatives, initiators and/or oils. The topical formulations are capable of delivering transdermal active agent(s) such as vitamin D through the skin and into the bloodstream without the use of skin penetration enhancers. In certain embodiments, the topical formulations also able to deliver topical active agent(s) such as sun-protecting agents to the surface of the skin where they remain, while simultaneously delivering the transdermal active agent(s) through the skin and into the bloodstream.

Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.

Abstract: This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.