Patents by Inventor David A. Edgar

David A. Edgar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5737754
    Abstract: A cache memory includes: a plurality of tag memory blocks, each of which stores multiple compare addresses; a first bus which sends a low order address to all of the tag memory blocks; a respective output from each tag memory block on which a compare address is read in response to the low order address; a second bus which carries a high order address; and, a comparator circuit which generates a miss signal when the compare address on the output from every tag memory block miscompares with the high order address. Each tag memory block further stores respective control bits with each compare address; and each tag memory block responds to the low order address by reading the compare address and the respective control bits, in parallel, on its respective output.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: April 7, 1998
    Assignee: Unisys Corporation
    Inventor: David Edgar Castle
  • Patent number: 5438121
    Abstract: The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: August 1, 1995
    Assignees: Max-Planck-Gesellschaft zur Foderund der Wissenschaften e.V., Regeneron Pharmaceuticals, Inc.
    Inventors: Yves-Alain Barde, Joachim Leibrock, Friedrich Lottspeich, David Edgar, George Yancopoulos, Hans Thoenen
  • Patent number: 5229500
    Abstract: The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: July 20, 1993
    Assignees: Regeneron Pharmaceuticals, Inc., Max Planck Gesellschaft
    Inventors: Yves-Alain Barde, Joachim Leibrock, Friedrich Lottspeich, David Edgar, George Yancopoulos, Hans Thoenen
  • Patent number: D243819
    Type: Grant
    Filed: January 7, 1976
    Date of Patent: March 29, 1977
    Assignee: Dazey Products Company
    Inventors: Donald Lee Avise, David Edgar Keepper, Lewis Aaron Mendelson