Abstract: The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.

Abstract: A bag for medical use having three compartments, and having a compartment containing a solvent, a compartment containing a solute and a compartment containing a solvent, the compartment containing a solute being separated from the other two compartments by pincers, the opening of which allows liquid to flow by gravity, and, during opening of one of the pincers and under the effect of a pressure, the liquid contained in one compartment is propelled towards another compartment. A method for using a bag for medical use having three compartments is also provided.

Abstract: A joystick assembly for a working machine having a working arm includes a controller configured to control a plurality of machine functions, a first electronic joystick in communication with the controller, and actuators in communication with the controller. Each actuator is configured to actuate a function associated with the working arm. The first electronic joystick comprises four axes of movement, and the first electronic joystick is configured to transmit electronic signals to the controller in response to being displaced along an axis from a neutral position. The controller is configured to receive the electronic signals from the first electronic joystick, and to transmit an electrical signal to one or more actuators to actuate the actuators. The joystick assembly is configured such that the controller actuates a different actuator for controlling a different function associated with the working arm, dependent upon the axis of displacement of the first electronic joystick.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention relates to the use of Lactobacillus rhamnosus in combination with Bifidobacterium longum to manufacture a formulation to increase male fertility in a subject. In particular, said strains are the strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347. Additionally, the formulation comprising the said strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347 is also described.

Abstract: The present invention provides engineered ?-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with ?-glucose linkages.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention relates to calpain inhibitors for use in the prevention and/or treatment of adverse ventricular remodelling. In particular, they are for use in the adverse ventricular remodelling accompanying a myocardial infarction or due to chronic hypertension. The invention also relates to particular compositions comprising these inhibitors.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: Robotic arms or manipulators can be used to toss inventory items within an inventory system. Tossing strategies for the robotic arms may include information about how a grasped item is to be moved and released by a robotic arm to achieve a trajectory for moving the item to a receiving location. A tossing strategy may also use a trajectory that avoids time and/or space reserved for a trajectory of another tossed item. The receiving location can include surfaces and/or other features that can be manipulated for receiving the item based on one or more characteristics of the tossed item and/or a trajectory of the tossed item.

Abstract: Robotic arms or manipulators can be used to toss inventory items within an inventory system. Tossing strategies for the robotic arms may include information about how a grasped item is to be moved and released by a robotic arm to achieve a trajectory for moving the item to a receiving location. A tossing strategy may also use a trajectory that avoids time and/or space reserved for a trajectory of another tossed item. The receiving location can include surfaces and/or other features that can be manipulated for receiving the item based on one or more characteristics of the tossed item and/or a trajectory of the tossed item.

Abstract: A slow-light generating optical device (1) is disclosed. The optical device comprises a planar waveguide (2), and the planar waveguide comprises: a longitudinal extending guiding region (4) with a first side (6) and a second side (8), a first nanostructure (7) arranged on the first side (6) of the guiding region (4), and a second nanostructure (9) arranged on the second side (7) of the guiding region (4). The planar waveguide (2) includes a first longitudinal region where the first nanostructure (7) and the second structure (9) are arranged substantially glide-plane symmetric about the guiding region (4) of the planar waveguide, and the first and the second nanostructures (7, 9) are designed so that the planar waveguide has a band structure and is adapted to guide a forward propagating mode and a backward propagating mode possessing energy bands, which individually are non-degenerate and mutually degenerate, and which intersect each other and form a Dirac point at a Brillouin zone edge.

Abstract: Robotic arms or manipulators can be used to toss inventory items within an inventory system. Tossing strategies for the robotic arms may include information about how a grasped item is to be moved and released by a robotic arm to achieve a trajectory for moving the item to a receiving location. A tossing strategy may also use a trajectory that avoids time and/or space reserved for a trajectory of another tossed item. The receiving location can include surfaces and/or other features that can be manipulated for receiving the item based on one or more characteristics of the tossed item and/or a trajectory of the tossed item.

Abstract: Disclosed herein is a matching of multiple different social graphs to generate a combined social graph. Such a combined social graph may be searched and used in determining information to provide to a user, for example. An iterative metric learning approach may be used in matching multiple different social graphs. A mechanism is provided to validate a match from different social graphs. Match validation of data field matching is provided.

Abstract: An item that is moving along a moving surface of an inventory conveyance system may be identified. An orientation of the item with respect to the moving surface may be determined based on sensing information that describes the item and a portion of the moving surface surrounding the item. A removal strategy for operating a robotic arm to remove the item from the moving surface may be determined based at least in part on the item and the orientation. The removal strategy may include a trajectory for the robotic arm to follow as part of removing the item from the moving surface.

Abstract: The present invention relates to the use of Lactobacillus rhamnosus in combination with Bifidobacterium longum to manufacture a formulation to increase male fertility in a subject. In particular, said strains are the strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347. Additionally, the formulation comprising the said strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347 is also described.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.