Abstract: A latch assembly is provided, the latch assembly having: a chassis, a latch bolt having a closed position and an open position a pawl having an engaged position and a disengaged position an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis wherein when the pawl moves from the engaged position to the disengaged position the eccentric arrangement rotates about the eccentric axis to move the pawl axis from a first pawl axis position to a second pawl axis position, a retaining mechanism having a retaining position at which the pawl axis is held in the first pawl axis position and having a non-retaining position at which the pawl axis is allowed to move to the second pawl axis position, a release lever configured to move the retaining mechanism between the retaining position and the non-retaining position.

Abstract: A molecule which recognises holo-DBP but which does not recognise apo-DBP or has relatively low affinity thereto.

Abstract: The present invention relates to method for assaying anti-cyclic citrullinated peptide antibodies in a clinical sample, said method comprising contacting said sample with at least one homogeneous reagent comprising at least one specific binder for anti-CCP antibodies, whereby to form a solution or suspension of an anti-CCP-binding partner complex in a homogeneous sample mixture and detecting the presence or level of said anti-CCP-binding partner complex in a homogeneous liquid-phase. The invention also relates to a method for the assessment of the existence of; risk of; potential for; or propensity to RA in a subject.

Abstract: A method of forming an integrated circuit includes forming first structures in a first portion of the integrated circuit and forming second structures, which are arranged more densely than the first structures, in a second portion. The first and second structures are defined by lithography processes using photomasks. At least one of the photomasks includes both openings in a first region for supporting the definition of the first structures and openings in a second region for supporting the definition of the second structures.

Abstract: Semiconductor device with a first structure comprising a plurality of at least in part parallel linear structures, a second structure comprising a plurality of pad structures, forming at least in part one of the group of linear structure, curved structure, piecewise linear structure and piecewise curved structure which is positioned at an angle to the first structure, and the plurality of pad structures are intersecting at least one of the linear structures in the first structure. An electronic device with at least one semiconductor device, methods for manufacturing a semiconductor device and a mask system are also covered.

Abstract: Provided is a method for the separation of blood cells from a blood sample, which method comprises: (a) contacting the blood sample with an agent having a binding component that binds blood cells to form bound blood cells; and (b) separating the bound blood cells from the blood, wherein the agent is capable of binding a plurality of different blood cell types, and wherein the binding component is capable of binding to a protein expressed on a surface of the blood cells.

Abstract: Provided is a vector for use in delivering a therapy to or removing a therapy from a site within a patient, wherein the vector comprises: a) a binding moiety; and b) a therapeutic agent, wherein the binding moiety comprises a metal-binding protein, polypeptide or peptide which is bound to or encapsulates a magnetic or magnetisable substance, and wherein the vector is to be administered using a device comprising an electromagnet and an element suitable for bringing the therapeutic agent into proximity with the site.

Abstract: A transistor integration process provides a damascene method for the formation of gate electrodes and gate dielectric layers. An interlayer-dielectric film is deposited prior to the gate electrode formation to avoid the demanding gap fill requirements presented by adjacent gates. A trench is formed in the interlayer-dielectric film followed by the deposition of the gate material in the trench. This process avoids the potential for damage to high-k gate dielectric layers caused by high thermal cycles and also reduces or eliminates the problematic formation of voids in the dielectric layers filling the gaps between adjacent gates.

Abstract: A windshield wiper assembly is provided having a unitary wiper arm and post, and a mechanical linkage for receiving the post and moving the arm. The post has a breakaway feature for breaking the post in response to impact. The wiper includes a head partially containing a center post and a button biased with a spring and connected to the center post for releasing the post from the linkage. The post and linkage include a captive ball and mating groove that are mutually engageable for securing the post to the linkage. Alternately, the post has a quick-connect end having a groove and the linkage has a receiving portion with a retractable collar and captive ball bearings. A vehicle is also provided including a windshield, a windshield wiper having a post, a wiper motor, and a mechanical linkage having an opening for receiving the post and powering the wiper.

Abstract: The present invention provides an imaging method for obtaining an image of a patient by means of a contrast agent wherein the method comprises subjecting the patient to an imaging method for which the contrast agent is suitable, wherein the contrast agent comprises: (a) a binding moiety; and (b) a recognition moiety capable of targeting the contrast agent to a site within the body of the patient, and wherein the binding moiety comprises a metal-binding protein, polypeptide or peptide which is bound to or encapsulates a magnetic or magnetizable substance.

Abstract: Provided is a sample collection container comprising one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent.

Abstract: An axle shaft is fabricated from two separate pieces. The axle shaft is comprised of an axle shaft body having a forged initial flange portion formed at one end. An axle shaft flange, fabricated by stamping or casting for example, is secured to the forged initial flange portion at a weld interface to form a finished axle shaft.

Abstract: Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different functional particle in one or more binding zones, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit to two or more separate functional zones; wherein, each different functional particle has, or can be controlled to have, a different function in the fluid as compared with the other functional particles; and wherein the separating conduit separates into two or more functional conduits, such that the separating conduit serves to separate the bound analytes into the separate functional conduits by means of the different functions of the different functional particles.

Abstract: Provided is a label for an analyte, which label is attached to a magnetic or magnetizable substance, the label comprising: (a) a recognition moiety for attaching the label to the analyte; and (b) a moiety for binding or encapsulating the magnetic or magnetizable substance; wherein the moiety for binding or encapsulating the magnetic or magnetizable substance comprises a metal-binding protein, polypeptide, or peptide.

Abstract: A memory cell array includes a number of memory cells, each of the memory cells including a source and a drain region defined by corresponding bitlines within a semiconductor substrate. Each of the bitlines has a doped semiconductor region as well as a conductive region in direct electrical contact with the doped semiconductor region.

Abstract: Provided is a method for determining the presence or absence of a pathogen in a sample, which method comprises: a) contacting the sample with a whole or a part of a cell surface receptor protein capable of binding the pathogen; b) allowing the cell surface receptor protein or part thereof to bind the pathogen; c) determining the presence or absence of the pathogen bound to the receptor protein or part thereof.