Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: A movement transfer mechanism for a surgical scoping device, wherein a rotational proximal input force is transformed into a longitudinal force that is conveyed down the length of an instrument channel of the scoping device, where it is transformed again into an operational movement of a distal instrument. The operational movement can be rotational movement, but may be any movement that changes the orientation or configuration of the distal instrument. By conveying a linear force along the instrument channel rather than a twisting force, the problems of slipping and discontinuous operation of the distal instrument due to friction between the instrument and the instrument channel can be reduced or eliminated.

Abstract: A utility knife includes a handle base and a neck connected to the handle base for pivotal movement relative to the handle base between a closed position and an open position. The knife also includes a utility blade holder slidingly carried by the neck for sliding movement relative to the neck between a retracted position and an extended position. A utility blade is carried by the blade holder such that movement of the utility blade holder between its extended and retracted positions moves the utility blade between an exposed position in which a cutting edge of the blade is exposed, and a protected position in which the cutting edge of the blade is protected by the neck.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: A diverter assembly may include a diverter body assembly. The diverter body assembly may also include a diverter body, the diverter body fluidly coupled to the annulus of a wellbore via a casing or riser, and the diverter body including one or more diverter outlet ports fluidly coupled to the annulus of the wellbore. The diverter body assembly may also include an upper packer assembly. The upper packer assembly may include a packer sleeve, the packer sleeve mechanically coupled to the diverter body. The packer sleeve may include one or more breach lock slots. The upper packer assembly may also include an upper packer body having one or more packer breach lock tabs engaged with the breach lock slots of the packer sleeve. The diverter assembly may also include a diverter support housing, the diverter support housing coupled to the diverter body assembly.

Abstract: Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF.

Abstract: A diverter assembly may include a diverter body assembly. The diverter body assembly may also include a diverter body, the diverter body fluidly coupled to the annulus of a wellbore via a casing or riser, and the diverter body including one or more diverter outlet ports fluidly coupled to the annulus of the wellbore. The diverter body assembly may also include an upper packer assembly. The upper packer assembly may include a packer sleeve, the packer sleeve mechanically coupled to the diverter body. The packer sleeve may include one or more breach lock slots. The upper packer assembly may also include an upper packer body having one or more packer breach lock tabs engaged with the breach lock slots of the packer sleeve. The diverter assembly may also include a diverter support housing, the diverter support housing coupled to the diverter body assembly.

Abstract: Various embodiments provide an electrosurgical system for treating biological tissue. The system comprises: an electrosurgical generator configured to supply pulsed microwave energy; and an electrosurgical instrument. The electrosurgical instrument comprises a flexible coaxial cable arranged to convey the pulsed microwave energy; and a radiating tip portion connected at a distal end of the coaxial cable and configured to receive the pulsed microwave energy. The radiating tip portion has a maximum outer diameter that is 1.0 mm or less, and wherein the maximum outer diameter of the radiating tip portion is smaller than an outer diameter of the coaxial cable. Also, the radiating tip portion comprises: a proximal coaxial transmission line for conveying the pulsed microwave energy; and a distal needle tip mounted at a distal end of the proximal coaxial transmission line, the distal needle tip being arranged to deliver the pulsed microwave energy into biological tissue.

Abstract: An electrosurgical system for treating biological tissue that comprises: an electrosurgical generator to supply microwave energy; a surgical scoping device having a steerable insertion cord for insertion to a treatment site; and an electrosurgical instrument dimensioned to fit within an instrument channel that is located within the insertion cord. The electrosurgical instrument comprises: a flexible coaxial cable arranged to convey the microwave energy; and a radiating tip portion connected at an end of the coaxial cable and configured to receive microwave energy. The radiating tip portion comprises: a coaxial transmission line for conveying the microwave energy; and a needle tip mounted at an end of the proximal coaxial transmission line, wherein the electrosurgical instrument is slidable within the instrument channel to extend the needle tip beyond an end of the instrument channel to puncture biological tissue; the needle tip is arranged to deliver the microwave energy into biological tissue.

Abstract: In some examples, a randomization searching engine is described that enables randomized searching and recommendation of authorized user profiles. The randomization searching engine implements a search routine that identifies search results by prioritizing authorized user profiles, bucketizing authorized user profiles, categorizing authorized user profiles results, collating authorized user profiles, and generating a set of search results.

Abstract: Skin treatment apparatus comprising an energy applicator structure configured to establish heating or ablation at a predetermined and controllable (i.e. selectable) depth below a surface of skin tissue with which it is in contact. The applicator structure may receive a cooling medium and microwave frequency electromagnetic energy, which provide a combined treatment effect that results in heating or ablation in a zone beneath the skin surface. The applicator may be a waveguide (e.g. waveguide horn antenna) with internal shielding configured to provide a substantially uniform heating effect. The applicator may include a thermal camera to monitor treatment.

Abstract: Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF.

Abstract: An electrosurgical forceps instrument in which an energy conveying structure for efficiently transferring electromagnetic energy (e.g. microwave energy and/or radiofrequency energy) from a coaxial cable to electrodes on the forceps jaws is incorporated into a compact jaw opening structure. The jaw opening structure may be dimensioned to be suitable for insertion down the instrument channel of a endoscope or other scoping device. Alternatively, the device may be configured as a laparoscopic device or be used in open procedures. The instrument may be used as a tool to perform new minimally invasive surgical techniques such as Natural Orifice Transluminal Endosurgery (NOTES) or the like.

Abstract: An electrosurgical device having a radiating tip portion for delivering electromagnetic energy to biological tissue, where the electrosurgical device is disposed in a catheter. The electrosurgical device is movable relative to the catheter between a deployed position where the radiating tip portion is exposed and a retracted position where the radiating tip portion is contained within the catheter. In this manner, the radiating tip portion may be retracted until the moment when it is to be used. This may facilitate insertion of the device through an instrument channel of a surgical scoping device. In particular, this may prevent the radiating tip portion from catching on the instrument channel when the device is inserted into the instrument channel, which could cause damage to the instrument channel and/or radiating tip portion.

Abstract: In one aspect, the disclosure presents an electrosurgical instrument for performing haemostasis by radiating microwave energy from a distal tip, where conductive radiating electrodes are coated in an insulating non-stick material. In another aspect, the disclosure provides an electrosurgical instrument for performing haemostasis using radiofrequency or microwave electromagnetic energy, where a distal tip of the instrument comprises a conductive hollow needle for conveying fluid to or from a treatment site, wherein the hollow needle is electrically grounded.