Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

Abstract: A securing system includes a fastener and a tape. The fastener includes a main body portion having a first end and a second end, a curved portion extending from the first end, first and second legs extending from the second end, and a roller extending between the first and second legs. The tape may extend around the roller and may be self-adhering.

Abstract: A method for making a secure payment, the method comprising the steps of: entering, using an online secure payment system, one or more pieces of information associated with a transaction for a customer from a biller; generating, via the online secure payment system, a digital bill for the customer from the one or more pieces of information; associating the digital bill with an account for the customer in the online secure payment system and alerting the customer to a change in status in the account; receiving, with the online secure payment system, a payment instruction for the digital bill from the customer; and processing, with the online secure payment system, the payment instruction for the digital bill and sending payment of the digital bill to the biller.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing template-based excerpting and rendering of multimedia performances technologies. An embodiment includes at least one computer processor configured to retrieve a first content instance and applying a template that results in transforming the first content instance. The first content instance may include a plurality of structural elements. The first content instance may be transformed by a rendering engine running on the at least one computer processor and/or transmitted to a content-playback device. An embodiment of transforming the first content instance includes trimming the content instance based on requirements provided by social media platforms.

Abstract: Systems and methods include a random number pool in communication with a random number device. One or more sets of key data elements are developed using the random number device with one or more variables input into the random number device from the random number pool.

Abstract: Interactive assistances for executing natural language queries to data sets may be performed. A natural language query may be received. Candidate entity linkages may be determined between an entity recognized in the natural language query and columns in data sets. The candidate linkages may be ranked according to confidence scores which may be evaluated to detect ambiguity for an entity linkage. Candidate entity linkages may be provided to a user via an interface to select an entity linkage to use as part of completing the natural language query.

Abstract: A secure connection to a router web UI is provided. In one implementation, responsive to a client request to securely connect to a router web server (RWS), the RWS generates and sends a certificate signing request (CSR) to a remote-security certificate server (R-SCS). Upon validation of the RWS, the R-SCS signs and transmits a router web UI certificate (RWUIC) to the RWS to present to the client. In another implementation, the router includes a local-SCS (L-SCS) that periodically obtains a short-lived intermediate certification authority (ICA) certificate from the R-SCS. Responsive to a client request for secure access to the RWS, the RWS generates and sends a CSR to the L-SCS for the RWUIC. The L-SCS signs the RWUIC and passes the ICA certificate and RWUIC to the RWS, which presents the certificate(s) to the client. Upon validation of the certificate(s), a secure channel between the client and RWS is established.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing template-based excerpting and rendering of multimedia performances technologies. An embodiment includes at least one computer processor configured to retrieve a first content instance and corresponding first metadata. The first content instance may include a first plurality of structural elements, with at least one structural element corresponding to at least part of the first metadata. The first content instance may be transformed by a rendering engine running on the at least one computer processor and/or transmitted to a content-playback device.

Abstract: Among other things, the present disclosure provides compounds, compositions thereof, and methods of using the same. In some embodiments, compounds of the present disclosure bind to Fc receptors, e.g., CD16a. In some embodiments, compounds of the present disclosure are useful for treating various conditions, disorders or diseases including cancer.

Abstract: An exemplary method of indicating a condition of grout within a post-tensioned tendon involves positioning a magnet and a metallic sensing plate in close proximity to an outer surface of the post-tensioned tendon; rotating the magnet and the metallic sensing plate around the outer surface of the post-tensioned tendon; measuring an amount of magnetic forces applied to the magnet during rotation of the magnet around the post-tensioned tendon; measuring an impedance between the metallic sensing plate and metallic strands within the post-tensioned tendon during rotation of the metallic sensing plate around the post-tensioned tendon; and generating an image of a cross-section of the post-tensioned tendon indicating one or more grout conditions in spatial proximity to the metallic strands within the post-tensioned tendon based on measurement data using the magnet and the metallic sensing plate.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.

Abstract: A nasopharyngeal airway device includes an elongate body having a distal end and a proximal end. The elongate body has an outer surface defining one or more open channels extending along the elongate body. The nasopharyngeal airway device includes a securement component securely coupled to the elongate body. The securement component is configured to secure the nasopharyngeal airway device within a nostril of an individual.

Abstract: The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Among other things, the present disclosure provides compounds, compositions thereof, and methods of using the same. In some embodiments, compounds of the present disclosure bind to Fc receptors, e.g., CD16a. In some embodiments, compounds of the present disclosure are useful for treating various conditions, disorders or diseases including cancer.

Abstract: The present invention provides improved methods for preparing a compound comprising Formula (I).

Abstract: The present invention provides methods for the purification of the compound of Formula (I) from the precipitated reaction product comprising the compound of Formula (I), impurities, and/or residual or entrained solvents.

Abstract: This disclosure is directed to a disposal container system enabling storage of used or contaminated articles having a generally flat, strip-shaped configuration, such as diagnostic biosensors. The disposal container is removably mountable to a supply container, and has an insertion portion provided in a wall of the disposal container. The insertion portion has a contour configured externally to guide deposit of a flat, strip-shaped article through a narrow slit, the contour further configured internally to deflect any loose articles in the interior space of the disposal container away from any accidental alignment with the slit which would cause free extraction of the articles. The disposal container may be configured for engagement with a supply container, such as a round or non-round vial, in a bottom-cap configuration or in a side-by-side configuration, by way of an engagement portion.

Abstract: An exemplary method of indicating a condition of grout within a post-tensioned tendon involves positioning a magnet and a metallic sensing plate in close proximity to an outer surface of the post-tensioned tendon; rotating the magnet and the metallic sensing plate around the outer surface of the post-tensioned tendon; measuring an amount of magnetic forces applied to the magnet during rotation of the magnet around the post-tensioned tendon; measuring an impedance between the metallic sensing plate and metallic strands within the post-tensioned tendon during rotation of the metallic sensing plate around the post-tensioned tendon; and generating an image of a cross-section of the post-tensioned tendon indicating one or more grout conditions in spatial proximity to the metallic strands within the post-tensioned tendon based on measurement data using the magnet and the metallic sensing plate.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing user-generated templates for segmented multimedia performances. An embodiment includes at least one computer processor configured to transmit a first version of a content instance and corresponding metadata. The first version of the content instance may include a plurality of structural elements, with at least one structural element corresponding to at least part of the metadata. The first content instance may be transformed by a rendering engine triggered by the at least one computer processor.