Abstract: An endovascular grommet includes a central member including a central portion and first and second portions extending from the central portion. The endovascular grommet further includes an inner ring connected to the central member, a first outer ring connected to the central member, a second outer ring connected to the central member, a first coil secured to the first portion of the central member, and a second coil secured to the second portion of the central member. The grommet is configured for deployment within an in-situ fenestration.

Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).

Abstract: A modular acetabular cup assembly includes an acetabular cup, and a liner seated in the cup. The cup includes an end face, an apex opposite the end face, and a central axis extending between the apex and a center point of the end face. The liner includes an articular surface having a center of rotation which defines a pivot point of the acetabular cup assembly. In certain embodiments, the pivot point is laterally offset from the center point such that the end face is located between the pivot point and the apex.

Abstract: Approaches in accordance with various embodiments enable communication functionality to be added to an existing hardware component, such as a network interface controller (NIC), data processing unit (DPA), or network switch, rather than requiring an additional component such as a Front Haul Multiplexor (FHM)-type for cellular communications. Such an approach not only avoids the cost and complexity of managing additional hardware components, but can also reduce bandwidth needed for signal transmission. For downlink communications, data can be copied to the relevant radio units of a cell in a single cell deployment architecture to be transmitted to a target client device, such as a cellular handset. For uplink communications, data received from a client device to multiple radio units can undergo decompression and channel estimation before combining the data into a single signal or data stream.

Abstract: A prosthetic arm apparatus including a plurality of segments that provide a user of the prosthetic arm apparatus with substantially the same movement capability and function as a human arm. The segments are connectable to one another and connectable to a prosthetic support apparatus that may be adorned by the user. Some segments may provide movement about more than one axis using a single actuator. The prosthetic arm apparatus may include a user interface incorporated therein and may include one or more communication systems for communicating with external devices.

Abstract: A steering shaft assembly includes a steering shaft extending along a central longitudinal axis between opposite first and second end portions terminating at respective first and second ends. A recessed pocket extends axially into the first end. The first end portion is configured for receipt in a through bore of a clamp yoke. A flag device has a body configured for receipt in the recessed pocket and a flag extending radially outwardly from the body. The flag is configured to obstruct a fastener opening in the clamp yoke until the steering shaft is inserted into the through bore to a predetermined insertion position.

Abstract: A vibrational cup device is disclosed that prevents a drink from spilling as ice readjusts within. The vibrational cup device comprises a base component positioned on a bottom portion of a cup and sealed with O-rings. The base component is removable and comprises a rechargeable battery, a micro circuit board, a vibrational motor, a USB port with plug, and a motion sensor that tells the device when the cup is at a 45-to-60-degree angle. At these angles, the vibrational motor would engage for approximately 10 seconds to help break up the ice in the cup or to level out the ice to prevent the sudden release of ice cubes, thus spilling part of the drink.

Abstract: It is well understood in the medical industry that medical disorders can manifest as serious problems for the affected subjects, their families, and society. Today, psychiatrists, neurologists and other physicians treat these disorders with a variety of medications, many of which have significant negative side effects. The teachings provided herein are directed to a novel system and methods for treating certain neurological, psychological, psychiatric and medical disorders by delivering a “magnetic stimulation” to a subject's neural and perineural system using either a static or electromagnetic field to generate a modulated variable power multi-spectral magnetic stimulation on three axis; the modulated stimulation using methods that have predictable, controlled, modifiable, and repeatable characteristics.

Abstract: The invention is an inhalation device for delivering an atomized mixture of liquids with a regulated mixing ratio, comprising two reservoirs storing a liquid, for each reservoir a piezoelectric actuator (10a, 10b) for atomizing the liquid, and a liquid transferring member being in contact with the liquid and the piezoelectric actuator (10a, 10b), and a pressure sensor (16a, 16b) for detecting a user inhalation, a regulating electric circuit comprising a controller (18) generating an output PWM signal having a duty cycle, and an output stage (20a, 20b) comprising an inductor (12a, 12b) forming a resonant circuit with the piezoelectric actuator (10a, 10b), and a switch (14a, 14b) for driving the output stage (20a, 20b) by the output PWM signal, the mixing ratio of the atomized liquids is determined by the duty cycles of the output PWM signals.

Abstract: A system for delivering ultra-high dose rate irradiation to a target area of a patient, includes a pulsed charged-particle source along a beam axis; a collimator for shaping the beam of radiation; one or more cameras for imaging the target area of the patient; and a dosimetry controller for providing control signals to the charged-particle source one or more dosimeters positioned between an output of the charged-particle source and the collimator in beam fringes for measuring a radiation dosage provided by each pulse; and a beam scanning coil positioned between the collimator and the patient for directing the shaped beam. The dosimetry controller receives feedback from the one or more dosimeters and provides control signals to the particle source and the beam scanning coil that modulate final pulses in the series of pulses in real-time.

Abstract: The present disclosure relates to intraocular, drug-eluting microparticle implants, as well as a dry microparticle formulation comprising a plurality of drug-eluting microparticle implants, for treating a condition of the eye, wherein the implant is configured to deliver a drug to the eye without a carrier. The present disclosure also relates to methods of treating a condition of the eye by delivering one or more drugs from drug-eluting implants or a dry microparticle formulation to the anterior chamber, posterior chamber (e.g., sulcus), iridocorneal angle, sclera, cornea, limbus, subconjunctival space, sub-Tenon's space, and vitreous.

Abstract: A method of releasing contracted tissue in a subject includes identifying an area of skin of the subject under which contracted tissue is present and applying, by a tip of a device, pressure to a first point of the area of skin. The first point is located over a fiber of the contracted tissue. The tip of the massage device has a cylindrical shape having a diameter of less than 1 millimeter and a length of less than 6 millimeters. The applied pressure releases a portion of the contracted tissue under the area of skin.

Abstract: A battery configured to support a relatively high rate of energy discharge relative to its capacity for energy intensive therapy delivery. The battery includes a feedthrough insulator cap disposed within the interior of the battery on at least a portion of a ferrule, at least a portion of an insulator, and at least a portion of a pin, which define a feedthrough extending through an enclosure of the battery; a first electrode disposed within the enclosure and electrically coupled to the pin; a second electrode disposed within the enclosure and separated a distance from the first electrode; and an electrolyte disposed between the first electrode and the second electrode. During operation of the battery, the feedthrough insulator cap reduces dendrite formation on at least a portion of the ferrule, the pin, or both.

Abstract: The present disclosure provides microbiome-friendly fragrance compositions adapted to mask, reduce or prevent malodours and consumer products comprising such a microbiome-friendly fragrance composition.

Abstract: An apparatus for remote interaction with an object includes a local system and a remote system. The local system includes a mixed reality headset configured to display a virtual representation of a physical element relative to the object, and a device configured to obtain information relating to or dependent on position and orientation of the physical element interacting with the object. The remote system includes an electronic device including a display for displaying an image based on the information, and an input device for remote user interaction and configured to control position and orientation of the virtual representation displayed on the mixed reality headset. The remote system is configured to communicate with the local system with latency of 0.5 seconds or less, facilitating alignment of the physical element with the position and orientation of the virtual representation.

Abstract: Provided herein are pharmaceutical dosage forms for delivering peptide therapeutics to a mucosal surface. The pharmaceutical dosage forms comprise a mucoadhesive layer; a peptide loading layer; and a water impermeable layer, wherein the peptide loading layer is between the mucoadhesive layer and the water impermeable layer, such that the water impermeable layer facilitates unidirectional movement of the encapsulated peptide through the mucoadhesive layer and to the target mucosal surface. The pharmaceutical dosage form is suitable for delivery of the encapsulated peptide therapeutic to buccal mucosa; sublingual mucosa; palate mucosa; and tongue mucosa. The peptide therapeutic may be an insulin; an insulin derivative; an insulin analog; a pre-insulin; a pro-drug of insulin; a glucagon-like peptide 1 (GLP-1); a GLP-1 analog; a pre- GLP-1; a pro-drug of GLP-1; or a combination thereof and may be suitable for the treatment of diabetes.

Abstract: Systems, devices, and/or methods relating to surgical procedures, and more specifically for providing access to an insufflated cavity of a patient and/or positioning surgical systems or devices into the cavity during surgical procedures. Access and insertion devices configured to couple with sealing devices, such as sealable sleeve devices and wound retractor devices. Access and insertion devices configured to provide fluidic sealing about a portion of a surgical device during surgical procedures.

Abstract: This invention is directed to a topical nitric oxide formulation that can be used to treat skin conditions. The invention is also directed to a method for using the topical nitric oxide formulation to treat skin conditions, as well as to a device to administer the topical pharmaceutical formulation to an area of the skin that requires treatment.

Abstract: The present invention relates to a pharmaceutical composition comprising a PTH compound, wherein after subcutaneous administration the pharmacokinetic profile of the PTH compound exhibits a peak to trough ratio of less than 4 within one injection interval.

Abstract: Various systems and methods of delivering an implant to a target location of a body vessel are disclosed. A detachment system can include a tubular body including a lumen extending therethrough and a distal tube on a distal end of the tubular body. A loop wire can be affixed at a first end to the tubular body and can include a loop opening positioned approximate a distal end of the distal tube. A pull wire can extend through the lumen. A hook wire can extend radially through a sidewall of the distal tube and into the lumen. The hook wire can be positioned around a pull wire portion and tensioned such that the pull wire portion abuts the distal tube and provides frictional resistance between the pull wire portion and the sidewall of the distal tube. The frictional resistance can be effective to inhibit premature detachment of the implant.