Abstract: The present disclosure provides compositions and methods of use for Type V CRISPR/Cas proteins. Type V CRISPR/Cas proteins may be configured to bind and modify nucleic acids in a sequence specific manner.

Abstract: A vascular occlusion catheter for at least partial occlusion of a target vessel includes proximal and distal shafts, with an occlusion balloon connected therebetween. The proximal shaft has a proximal internal lumen, in fluid communication with the occlusion balloon. The distal shaft has a distal internal lumen. A hypotube having an internal lumen extends through the proximal lumen and the occlusion balloon and into communication with the distal lumen. The catheter includes at least one of (i) a distal sensor positioned within the distal lumen and facing an opening formed in the distal shaft, or (ii) the proximal shaft further includes a sensor lumen, and a proximal sensor is positioned within the sensor lumen and facing an opening formed in the proximal shaft. A display hub is mounted to the proximal shaft, and is electrically connected with the at least one of the distal sensor or the proximal sensor.

Abstract: The disclosure relates to defined solutions for organ (heart, liver, kidney, etc,) vascular composite allografts or autografts (VCA: hand, limb, face, etc.) or tissue (peripheral nerves, spinal cord, skin) storage that preserve the electrophysiological functions of axons contained therein. The disclosure also concerns the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft or allograft transplantation procedures, as well as the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft/allograft transplantation procedures in combination with the peripheral nerve repair techniques of neurorrhaphy and axonal fusion primarily using polyethylene glycol known as PEG-fusion.

Abstract: A bone plate comprises a plate body and at least one tab. The plate body defines an inner body surface configured to face an underlying bone, an outer body surface opposite the inner body surface, and an outer side surface that extends between the inner body surface and the outer body surface. The outer side surface defines an outer perimeter of the plate body. The at least one tab includes a head and an arm that extends from the plate body to the head. The tab defines a tab aperture that extends through the head and is configured to receive a bone anchor. The bone anchor can be coupled with a screw hole in the nail. The arm is configured to deflect with respect to the plate body so as to move the head between a pre-fixation position and a fixation position spaced from the pre-fixation position.

Abstract: Devices and methods for regulating vacuum levels in a chamber device having a housing that encloses an inner chamber volume through the use of one or more pressure relief valve elements which open at a predetermined levels of vacuum to create an opening through the housing and which close at a second, lower, predetermined level of vacuum within the chamber volume.

Abstract: A method for coagulating and dissecting tissue. The method includes measuring a tissue property and delivering multiple energy modalities to the tissue based on the tissue property. The energy modalities being delivered from a generator either alone or in combination.

Abstract: Embodiments are directed to a rotorcraft comprising an airframe having an engine compartment, an engine disposed within the engine compartment, at least one fire bottle configured to hold a fire extinguishing agent, at least one agent tube coupled to the fire bottle and configured to carry the fire extinguishing agent to the engine compartment, and a nozzle on the at least one agent tube, the nozzle positioned below the engine and oriented in a upward-facing direction. The nozzle has at least one opening that is closed by a spring-loaded valve.

Abstract: The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA to treat Hutchin-son-Gilford progeria syndrome (HOPS). The disclosure also provides fusion proteins, guide RNAs and compositions comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA, for example in a LNA gene. In some embodiments, adenosine deaminases provided herein are used to correct a C1824T mutation in LMNA. In some embodiments, the methods and compositions provided herein are used to treat Hutchinson-Gilford progeria syndrome (HGPS).

Abstract: Forms for constructing a first gate foundation and a second gate foundation in a support structure for positioning and supporting rotatable gates of throwing cages such as for discus, hammer, or discus/hammer throwing cages. The forms may include a first form and a second form. The forms may include an enclosure defining a cavity having an open upper end. The forms are installable in the support structure so that the enclosure is operable to form a horizontal pad for supporting a wheel of the rotatable gates of the throwing cage. In some embodiments, the forms may include an arcuate enclosure and/or a gate post support attached to the enclosure operable for supporting a gate post of a rotatable gate. In other embodiments, the forms may include a net pole support attached to the enclosure operable for supporting a net pole.

Abstract: Disclosed herein is a fragrance composition comprising an organic aerogel; and a non-edible active fragrance compound; where the organic aerogel comprises a biopolymer or a synthetically derived organic polymer; where the organic aerogel does not contain any inorganic aerogels and wherein the organic aerogels are not blended with or dispersed in hydrogels, inorganic aerogels or with non-aerogel polymers.

Abstract: A system and method are provided of minimizing network bandwidth used from an external network by client peers in a local network. The method can include the operation of organizing a plurality of clients each having media streamlets and a client parent in a structure within the local network. Mapping information propagates through the structure. The mapping information represents local streamlet locations as stored by the plurality of clients. Another operation is retrieving a local streamlet from a client identified in the mapping information as having the local streamlet for the requesting client.

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating or preventing inappropriate activation of a type I interferon (IFN) response in a subject in need thereof.

Abstract: A method for treating wastewater containing fluorine is disclosed. The method for treating wastewater includes applying a vacuum to a membrane unit including a membrane having a hollow, injecting wastewater into the membrane unit so that the wastewater contacts an outer surface of the membrane, recovering hydrofluoric acid gas by evaporating hydrofluoric acid (HF) in the wastewater based on a vacuum applied to the inner surface of the membrane and moving the evaporated hydrofluoric acid (HF) to the inner surface through the membrane, injecting sweep gas into the membrane unit to discharge hydrofluoric acid gas remaining on the inner surface of the membrane, and forming a metal fluoride by reacting the recovered hydrofluoric acid gas with a metal oxide or metal hydroxide using a scrubbing process.

Abstract: A rotorcraft includes a fuselage, a flight control computer, an auxiliary flight controller having one or more flight control inputs in the noncockpit section of the fuselage and a relay interposed between the flight control computer and the auxiliary flight controller such that the auxiliary flight controller is in data communication with the flight control computer via the relay. The relay prevents electromagnetic interference affecting the auxiliary flight controller from affecting the flight control computer.

Abstract: A method is for influencing and/or operating a steering system, in particular a steer-by-wire steering system. In the method, a setpoint for an operating element actuator is determined independently of a setpoint for a steering gear actuator, and the operating element actuator is actuated depending on the setpoint for the operating element actuator. The setpoint for the steering gear actuator of the steering system is determined independently of the setpoint for the operating element actuator, and the steering gear actuator is actuated depending on the setpoint for the steering gear actuator. The setpoint for the operating element actuator is determined depending on a target value for a behavior of an operating element and depending on a first request value. The setpoint for the steering gear actuator is determined depending on a target value for a behavior of the steering gear actuator and depending on a second request value.

Abstract: Some embodiments of a device comprise a cleaning-fluid-supply reservoir; a cleaning-fluid-supply conduit; one or more electrical connectors that are configured to be attached to a printhead and supply electrical signals to the printhead; one or more memories; and one or more processors that are in communication with the one or more memories. Also, the one or more processors cooperate with the one or more memories to cause the device to perform operations that include supplying cleaning fluid from the cleaning-fluid-supply reservoir, through the cleaning-fluid-supply conduit, to the printhead, and while supplying the cleaning fluid to the printhead, sending a signal to the printhead, through the one or more electrical connectors, to activate one or more piezo-electric actuators of the printhead.

Abstract: A random orbit sander includes a housing and a motor enclosed within the housing. The motor includes a motor shaft that is rotatable about a first axis. An eccentric carrier coupled to the motor shaft includes a circular internal bore that defines a second axis that is offset from the motor shaft. A bearing is received within the circular internal bore of the eccentric carrier. A sanding pad is supported by the bearing and is rotatable about the first axis in an eccentrically orbiting manner. The motor shaft and the eccentric carrier are integrally formed as a single piece.

Abstract: The tire (10) comprises a crown (12), two sidewalls (30A, 30B), two beads (32A, 32B), an inner surface (33) delimiting a toroidal cavity (35), and a stiffening structure (50) comprising a stiffening element (52) extending continuously into the toroidal cavity (35) from at least one of the sidewalls (30A, 30B) or one of the beads (32A, 32B) to the crown (12). The stiffening element (52) is anchored in or around: a radially inner reinforcing structure (60A, 60B) arranged in the sidewall (30A, 30B) and/or the bead (32A, 32B), the radially inner reinforcing structure (60A, 60B) being distinct from the circumferential reinforcing element (40A, 40B) situated on the same side of the median plane (M) of the tire (10) as the sidewall (30A, 30B) and/or the bead (32A, 32B), and a radially outer reinforcing structure (70A, 70B) arranged in the crown (12).

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Limb portion 1000, in particular a thigh, for a limb of a robot comprising a first actuator 1 adapted to pivotably couple with a first further limb section and a second actuator 2 adapted to pivotably couple with a second further limb section. In addition, the limb portion 1000 comprises a housing 4 enclosing a first heat source 10 of the first actuator 1 and a second heat source 20 of the second actuator 2. The housing 4 forms a cavity 40 that thermally couples to the first heat source 10 and to the second heat source 20. The housing comprises a first air opening 41 and an second air opening 42 for an airstream to vent the cavity 4.