Abstract: Aspects of the present disclosure relate to obstruction detector assemblies, systems, and related methods for detecting obstructions along oil and gas equipment. In one implementation, an obstruction detector assembly includes a driver housing having an internal chamber and a plurality of fastener openings. The obstruction detector assembly includes a driver stem disposed at least partially in the internal chamber of the driver housing. The driver stem is movable partially out of the internal chamber of the driver housing. The obstruction detector assembly includes a driver head disposed outside of the driver housing and coupled to the driver stem. In one implementation, movement of the driver stem and the driver head is used to detect obstructions (such as a wireline) in a wellhead structure. In one implementation, movement of the driver stem and the driver head is used to detect obstructions (such as sand) in a valve.

Abstract: A rock rail assembly for a vehicle includes a mounting assembly coupled to the vehicle and comprising a shock absorption pad, and a rail assembly pivotably coupled to the mounting assembly and having a rail. The shock absorption pad is the vehicle-laterally-outboardmost portion of the mounting assembly. The rail assembly is operable to pivot relative to the mounting assembly to move the rail between a stowed position and a deployed position. In the stowed position of the rail, a portion of the rail abuts the shock absorption pad.

Abstract: In various examples, a current claimed set of points representative of a volume in an environment occupied by a vehicle at a time may be determined. A vehicle-occupied trajectory and at least one object-occupied trajectory may be generated at the time. An intersection between the vehicle-occupied trajectory and an object-occupied trajectory may be determined based at least in part on comparing the vehicle-occupied trajectory to the object-occupied trajectory. Based on the intersection, the vehicle may then execute the first safety procedure or an alternative procedure that, when implemented by the vehicle when the object implements the second safety procedure, is determined to have a lesser likelihood of incurring a collision between the vehicle and the object than the first safety procedure.

Abstract: A dual-control electro-pneumatic foot brake system and method are provided for use with a vehicle having multiple foot brake modules that communicate electronic signals to an electronic brake controller. As a backup feature in case there is a problem with the electron braking system, one of the foot brake modules provides pneumatic pressure to the other foot brake module, which supplies the provided pneumatic pressure to various components of the vehicle's braking system. Other alternatives are provided.

Abstract: Apparatus, systems, and articles of manufacture are disclosed to power thermal management systems with heat of a working fluid therein. Example thermal management system include: a thermal transport bus loop fluidly coupled to at least one heat source exchanger and at least one heat sink exchanger; a turbomachine including a turbine and a compressor, the turbine and compressor rotatably interlocked via a shaft, the compressor coupled to the thermal transport bus loop, the turbine including an inlet and an outlet, the inlet connected to a first point of the thermal transport bus loop via a first flowline, the outlet connected to a second point of the thermal transport bus loop via a second flowline; and a control valve coupled to the first flowline, the control valve to adjust a mass flowrate of the heat exchange fluid in the first flowline based on a speed of the shaft.

Abstract: Human drivers generally cannot plan a collision evasion maneuver in the brief interval before impact, other than simply slamming on the brakes and hoping for the best. Often the collision could have been avoided by swerving or other sequence of actions. Therefore, improved collision avoidance and mitigation procedures are disclosed, based on a well-trained artificial intelligence (AI) model that takes over the accelerator, brake, and steering in an emergency. With fast electronic reflexes and AI-based computational power, the AI model can find a more effective avoidance maneuver, or at least an action that would minimize the harm (for example, by swerving to miss the passenger compartment). The AI model can then implement the sequence instantly, without fear or hesitation. The result—fewer collisions and less fatality on our highways.

Abstract: A fuel supply device includes a main body, fuel chamber, fuel supply pipe and a fuel valve. The main body has a main bore with an inlet for air and an outlet through which a fuel and air mixture flows. The fuel chamber retains a supply of fuel. The fuel supply pipe has a passage communicating with the main bore and through which fuel from the fuel chamber flows to the main bore. And the fuel valve has a valve seat, a valve element movable relative to the valve seat between an open position and a closed position, an inlet upstream of the valve seat and is in communication with the fuel chamber, and an outlet downstream of the valve seat. The outlet is coaxially aligned with the passage of the fuel supply pipe and the fuel valve is electrically operated to move the valve element.

Abstract: Disclosed is a friction ring including a body and a contact member. The body is configured to couple the friction ring to at least one of a faucet assembly or a faucet valve assembly. The contact member is disposed on the body. The contact member is configured to slidably engage with a valve stem of the faucet valve assembly. The contact member is further configured to press against the valve stem to increase a frictional force between the contact member and the valve stem over a full range of movement of the valve stem.

Abstract: A pool skimmer is disclosed that comprises a base component comprised of a bar with a U-shaped net component secured to it. The net component measures two to three feet wide and is comprised of fine, stainless-steel microns. A flexible, telescopic handle is then secured to the base component. The base component is placed inside of the swimming pool and comprises a flotation system to allow the device to be positioned halfway above the water level. The U-shaped net allows a user to capture small bugs, leaves, or other unwanted debris within the swimming pool quickly and efficiently.

Abstract: Among other things, the present disclosure provides designed PNPLA3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: A gas turbine engine includes a rotor that that has a seal surface, a shaft that has an annular seal channel that opens to the seal surface, and a seal disposed in the annular seal channel for sealing against the seal surface. The seal is made of a composite having carbon fibers disposed in a carbon matrix.

Abstract: The invention relates generally to tRNA-based effector molecules (TREMs) comprising an asialoglycoprotein receptor (ASGPR) binding moiety, as well as compositions and methods relating thereto.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Provided herein, are compositions comprising GalNAc moieties that may be conjugated to an oligonucleotide. The oligonucleotide may be a small interfering RNA or an antisense oligonucleotide. Also provided herein are methods of treatment that include administering the composition to a subject.

Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.

Abstract: Disclosed herein are compositions comprising an oligonucleotide that targets MST1. The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of treating conditions associated with MST1 mutations that include providing an oligonucleotide that targets MST1 to a subject.

Abstract: Disclosed herein are corrosion inhibitors suitable for heavy-duty industrial lubricants and industrial lubricating compositions including such corrosion inhibitors combined with phosphonate diesters to provide good copper corrosion and roller bearing protection. The corrosion inhibitor has a high content of dialkyl dithiothiadiazole compounds configured to maintain high levels of the phosphonate diester in the lubricant.

Abstract: Double stranded RNAi agents for inhibiting PCSK9 gene expression are provided. Complexes in which the siRNA agents are covalently conjugated to a peptide docking vehicle (PDoV), and further covalently linked to one or more targeting ligands also are provided. Pharmaceutical compositions containing the RNAi agents and complexes are provided, together with methods for their use.

Abstract: A method of monitoring a suspension member of an elevator system includes determining a condition of the suspension member based on a combination of an electrical inspection technique, a use indicator corresponding to an amount of use of the suspension member, and a mechanical characteristic indicator corresponding to at least one mechanical characteristic of the suspension member. The suspension member is removed from service based on an indication from the electrical inspection technique, the mechanical characteristic indicator, and the use indicator satisfying at least one predetermined combination of criteria.

Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.