Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.

Abstract: A surgical instrument comprises a proximal end. A distal end has an articulation region, a movement of which is controlled from the proximal end. A shaft is between the proximal end and the distal end. A plurality of steering cables extend from the proximal end to the distal end. An end effector comprises a clevis, the clevis including at least one channel that receives a portion of a steering cable of the plurality of steering cables.

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

Abstract: A lawn mower (10) may include a blade housing (20), an engine (30), a mobility assembly (310); and a drive system (300). The engine (30) may be operably coupled to the blade housing (20) and configured to selectively rotate a drive shaft (130). The mobility assembly (310) may include a first set of wheels (40, 42) and be selectively operably coupled to the engine (30) to provide mobility of the lawn mower responsive at least in part to operation of the engine (30). The drive system (300) may include a first transmission (110, 120), a flexible driving member (100), a disengagement assembly (116), and a remote actuator. The a disengagement assembly (116) may include a latching lever (125), where the latching lever (125) is configured to switch the first transmission (110, 120) between a disengaged mode and an engaged mode, and where the latching lever (125) is configured to move between a disengaged position corresponding to the disengaged mode and an engaged position corresponding to the engaged mode.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.

Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.

Abstract: Systems and methods for encrypting and decrypting data during an active data communication are disclosed. In one embodiment, seed data is received. A number of first seed bits are extracted from the seed data. The extracted first seed bits is used to index into a first index location of first one-time pad (OTP) data and obtain system setup random data from the first OTP data. System configuration information including a number of cipher parameters is defined based on the system setup random data, where the number of cipher parameters includes encryption cipher parameters and decryption cipher parameters. The data is encrypted or decrypted based, respectively, at least on the encryption cipher parameters or the decryption cipher parameters to generate encrypted data or decrypted data respectively.

Abstract: A design is described for solar panel that allows for modular installation and efficient removal of panels irrespective of the panel's relative location in an array arrangement. A system is provided that includes a plurality of modular panels (such as solar power panels). These panels are rimmed by frames featuring one or more exterior-facing, grooved channels. A first channel—which may be used to mount the panel, and which replaces traditional railing installation systems—and a second channel that is configured to allow movement of one or more panel splices used to secure the panels together. Integrated electrical connection interfaces are provided on opposite side surfaces of the frames to couple with the electrical connection interfaces of adjacent panels to establish an electrical path between them.

Abstract: An apparatus for feeding a fuel, characterized as irregularly shaped fuel chips, from a storage bin to a burner of a cooking grill, includes a conveyance having a plurality of vanes movable from a first position proximate to a fuel source to a second position proximate to a fuel delivery chute leading to the burner. A fuel supply is arranged to feed the fuel to the first position. A chute is arranged having a first end proximate to the second position and a second end proximate to the burner for delivery of the fuel from the vanes at the second position to the burner. The vanes are arranged to scoop up the fuel from the fuel source at the first position, and to deposit the fuel at the second position into the first end of the chute.

Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.

Abstract: De novo designed polypeptides that bind to IL-2 receptor ??cheterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.

Abstract: Embodiments described herein improve fuel economy by controlling a vehicle powertrain based on a predicted vehicle velocity. The vehicle velocity is predicted based on vehicle-to-vehicle data when a prediction horizon is a longer prediction horizon and the vehicle velocity is predicted based on historical drive cycle data when the prediction horizon is a shorter prediction horizon. A time duration of the shorter prediction horizon is shorter than the time duration of the longer prediction horizon. A plurality of drive cycles are established for both the longer and the shorter prediction horizons using a neural network. A shorter prediction horizon drive cycle uses nonlinear autoregressive exogenous model neural networks and the longer prediction horizon drive cycle uses two layer feedforward neural networks. The predicted vehicle velocity is determined from a similar drive cycle of the plurality of drive cycles of either the shorter and/or the longer prediction horizon drive cycles.

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

Abstract: The present invention relates to conjugates of cyclosporin with quinolium mitochondrial targeting groups, and their therapeutic uses.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.

Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.

Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.