Abstract: In some embodiments, a non-transitory processor-readable medium stores code representing instructions for execution by a computer processor. The instructions cause the processor to produce a list of subjects by identifying a plurality of subjects based on information associated with an analyst-selected topic. The list of subjects is expanded to include subjects that have a relationship with at least one subject from the first list of subjects. Subjects are removed from the list based on either a filter or a scoring threshold. The expanding and removing subjects is iterated until the list of subjects is substantially stable to produce a final list of subjects. A graphical network is defined based on the final list of subjects and a signal is sent representing the graphical network (e.g., to a computer monitor for display).

Abstract: A drive member and a rotation member are rotatable with respect to a housing. A stop member is rotationally locked with the housing. Clutches unidirectionally rotationally engage the drive member with the rotation member and with the stop member when a unit is attached to the housing. A separating member is disposed between the rotation member and the stop member. The separating member causes a separation of the rotation member, the drive member and the stop member when the unit is removed. A coupling feature of the separating member is provided to engage the unit and to move the separating member when the unit is being attached to the housing or is being removed.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: The present disclosure relates to an operation aid for a medication delivery device, which is configured to alleviate the operation of an actuator of the medication delivery device. Furthermore, a system comprising a medication delivery device and an operation aid is disclosed.

Abstract: Disclosed is a method (160) for identifying potential tamper in a candidate document having content affected by noise. A candidate content value for each of a plurality of sub-regions of the candidate document and an original content value for each of a plurality of sub-regions of a corresponding original document are determined. The content values are desirably determined based on at least one characteristic of the content in the corresponding sub-region. The candidate content values (330) are associated with the corresponding original content values and a distribution of the candidate content values based on the corresponding original content values is determined. The method characterizes (340) the noise in the candidate document by determining an expected content value range based on the spread of a selected part of the distribution of candidate content values. The method can then identify (350) candidate content values outside the expected content value range as potential tamper.

Abstract: In some embodiments, a system includes a software program capable of performing an aliasing function on the personally identifiable information (“PII”) of a subject. The software can associate the alias with the PII, and output the alias rather than the PII.

Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

Abstract: A tracking device is disclosed for communication of location coordinate information. In one embodiment, the tracking device includes a signal transceiver device, a location coordinate acquisition device, and a computational processor activated and deactivated in accordance with a subscriber service usage profile. The location coordinate acquisition device generates a position fix of the tracking device and a signal transceiver device reports the position fix to a location tracking server. A flash memory device stores a zone management map. In accordance with a fix reporting period based at least in part on a subscriber service usage application including or accessing the subscriber service usage profile, an internal clock activates or deactivates the signal transceiver device, the computational processor, and/or the location coordinate acquisition device.

Abstract: An electric machine includes a casing have a first end plate and a second end plate, the first end plate having an air inlet and the second end plate having an air outlet; an outer rotor positioned inside the casing; a stator positioned inside the outer rotor; a hub positioned inside the stator; a fan positioned within the casing, the fan drawing air from the air inlet and exhausting air out the air outlet.

Abstract: A prescription dispensing system having a dispensing station for holding an inventory of prescription medications, a secure internet connection to the dispensing station for access by a potential prescription medication recipient, by healthcare personnel in a physician office and by pharmacy personnel at the pharmacy distribution center in a remote location, at least two webcams for visual and auditory communication between the location of the dispensing station and the pharmacy personnel via the internet to allow identification of the correct medication, identification and communication with the correct potential prescription medication recipient, and visual validation and recording of all documentation from the physician's office or potential prescription medication recipient, and a biometric reader disposed at the dispensing station for identifying a potential prescription medication recipient.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII.

Abstract: A prescription dispensing system having a dispensing station for holding an inventory of prescription medications, a secure internet connection to the dispensing station for access by a potential prescription medication recipient, by healthcare personnel in a physician office and by pharmacy personnel at the pharmacy distribution center in a remote location, at least two webcams for visual and auditory communication between the location of the dispensing station and the pharmacy personnel via the internet to allow identification of the correct medication, identification and communication with the correct potential prescription medication recipient, and visual validation and recording of all documentation from the physician's office or potential prescription medication recipient, and a biometric reader disposed at the dispensing station for identifying a potential prescription medication recipient.

Abstract: A gas turbine engine including a segment of an annular guide vane assembly is provided. When the engine is used, the segment directs hot combustion gases onto rotor blades of the engine. The segment includes a platform disposed at a side of the segment radially inward/outward with respect to the axis of rotation of the engine. The platform has a trailing edge portion downstream with respect to the flow of hot combustion gases through the segment, the trailing edge portion includes a rail that extends radially inwardly/outwardly from the trailing edge portion. The engine also includes a support and cooling arrangement for supporting the segment and directing a cooling fluid to cool the segment. The arrangement is located radially inward/outward of the platform, and includes a flange part that extends radially outwardly/inwardly from the arrangement. The arrangement further includes a leaf seal and a retaining pin.

Abstract: A platform segment for supporting a nozzle guide vane for a gas turbine is provided. The platform segment includes a gas passage surface arranged to be in contact with a streaming gas exhausted from a combustor, wherein the streaming gas streams along the gas passage surface in a streaming direction, a cooling surface, opposite to and thermally connected to the gas passage surface and arranged to be in contact with a cooling fluid, a wall protruding from the cooling surface and extending at least partially in the streaming direction, wherein the wall is arranged circumferentially between positions, at which adjacent guide vanes are to be provided, such that cooling fluid is channeled by the wall for cooling a downstream portion of the cooling surface, and a further wall protruding from the cooling surface and extending at least partially in the streaming direction.

Abstract: A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids.

Abstract: A drive mechanism for a drug delivery device which can be switched between a normal operation mode and a reset mode comprises of a housing having a proximal end and a distal end, a piston rod which is adapted to be displaced in a distal direction with respect to the housing for delivering a dose in a normal operation mode of the drive mechanism, and which is adapted to be displaced in the proximal direction with respect to the housing in a reset mode of the drive mechanism, and a drive member which is rotationally moveable in a rotation direction with respect to the housing, wherein, in the normal operation mode, the drive member is coupled with the piston rod so that rotational movement of the drive member in the rotation direction with respect to the housing is converted into movement of the piston rod in the distal direction with respect to the housing, and wherein, in the reset mode, the piston rod is decoupled from the drive member.

Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.