Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A current injection gate is positioned between the first electrode and the light emitting layer or the second electrode and the light emitting layer. In some embodiments, the current injection gate comprises a semiconductor layer of electronic structure restricting injected current flow from the first or second electrode through the semiconductor layer as a function of alternating current voltage frequency applied to the first and second electrodes.

Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: In one aspect, methods of making a polycrystalline film are described herein. In some embodiments, a method of making a polycrystalline film comprises providing a nanoparticle composition comprising crystalline nanoparticles of copper-zinc-tin-chalcogenide disposed in a liquid carrier, wherein inorganic ligands are associated with surfaces of the copper-zinc-tin-chalcogenide nanoparticles, the inorganic ligands formed of a metal chalcogenide complex. The method further comprises depositing the nanoparticle composition on a substrate surface and removing the liquid carrier to provide the polycrystalline film of copper-zinc-tin-chalcogenide.

Abstract: The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) in which the variables are as described herein.

Abstract: Embodiments include an apparatus, a computer readable medium and a method for distributing tessellations within an accelerated processing device (APD) including at least two compute units. Embodiments include processing a plurality of patches in a first compute unit using a hull shader to generate hull shader output data. Once generated, hull shader output data is stored to an off-chip memory when tessellation factors associated with the shader program are greater than a configured threshold. Once stored in the off-chip memory, at least a portion of the hull shader output data is dynamically processed using a second compute unit.

Abstract: In one aspect, composite layers are described herein demonstrating phase-separated architectures which, in some embodiments, can mitigate performance disadvantages of prior organic layers of optoelectronic devices. A composite organic layer described herein comprises nanocluster nodes and carbon nanoparticles disposed in a conjugated polymeric host, wherein the carbon nanoparticles are substantially phase separated from the conjugated polymeric host forming lamellar structures of carbon nanofibrils radiating from the nanocluster nodes.

Abstract: In embodiments a drilling rig system includes a rig unit having rig equipment and a rig electrical subsystem configured for electrical communication with the rig equipment and including a rig electrical subsystem input transformer, an electrical system including a primary power supply subsystem remote from the rig unit, and an intermediate electrical subsystem.

Abstract: In embodiments a drilling rig system includes a rig unit having rig equipment and a rig electrical subsystem configured for electrical communication with the rig equipment and including a rig electrical subsystem input transformer, an electrical system including a primary power supply subsystem remote from the rig unit, and an intermediate electrical subsystem.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors.

Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The present invention is a measuring apparatus that is capable of facilitating the measurement of stud or truss placement behind a wall or beneath a roof. The invention comprises a measurement apparatus or system with indicators for informing the user of the exact measurement for the location of a stud behind a wall or a truss beneath a roof. Embodiments of the invention comprise: a retractable tape measure with such indicators visibly printed on the retractable tape, an optical projection system that projects a light image onto the work surface and indicates the location of studs or trusses on said work surface, and a retractable tape system that features flexible display technology and uses such technology to display indicators for stud and truss locations. The invention is customizable for configuration to the building codes or regulations of the region(s) in which the user is intending to use the apparatus or system.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.

Abstract: A new and distinct Ilex plant named ‘David Carroll’, characterized by its compact and rounded plant habit; freely branching habit; dense and bushy growth habit; bright yellow green-colored leaves; and good garden performance and winter hardiness.