Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: The present disclosure includes an electrosurgical apparatus for treating tissue at a target site. The apparatus has a shaft with a proximal end and a distal portion, the distal portion comprising a return electrode and electrode support. There is also at least one active electrode on the shaft distal portion, which has a proximal portion and a distal portion and a plurality of aspiration apertures disposed therebetween. These apertures are fluidly connected to a fluid aspiration cavity that is located within the electrode support, and the cavity is connected with a fluid aspiration element that is located along the shaft. The plurality of apertures vary in size and are generally arranged so that the larger sized apertures are disposed towards the electrode proximal portion and the smaller sized apertures are generally located towards the electrode distal portion.

Abstract: Buried object locator systems including transmitters and associated buried object locators using phase-synchronized signals are disclosed. A transmitter may generate output current signals that are phase-synchronized with a corresponding locator for improved utility locating.

Abstract: The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP inhibitor (e.g., E7449), and, optionally, a platinum-based antineo-plastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a platinum-based antineoplastic drug (e.g., carboplatin).

Abstract: A gravity feed tray is provided for use as a component of a display device for retail merchandise such as bottled soft drinks or water in a retail setting. The gravity feed tray includes a first and second support structure that are forwardly and downwardly inclined when coupled to a retail display bar. The first and second support structures having inwardly extending flanges that project into a merchandise channel formed by the first and second support structures. The inwardly extending flanges provide a surface to display retail merchandise. The support surfaces being disposed downwardly and forwardly along a straight line so that rows of retail merchandise, such as bottles, may be stocked in the merchandise channel and supported by the inwardly extending flanges, whereby removal of the bottle at the front end of the merchandise channel causes a void that the remaining bottles fill by sliding via gravitational force.

Abstract: An electrosurgical wand. At least some of the illustrative embodiments are electrosurgical wands including an elongate housing that defines a handle end and a distal end, a first discharge aperture on the distal end of the elongate housing, a first active electrode of conductive material disposed on the distal end of the elongate housing, a first return electrode of conductive material disposed within the first fluid conduit, and an aspiration aperture on the distal end of the elongate housing fluidly coupled to a second fluid conduit.

Abstract: Camera heads configured to provide digitally articulated images or video, at adjustable resolutions and/or offsets and orientations, to a camera control unit (CCU) or other electronic computing system for display, storage, and/or transmission to other systems are disclosed.

Abstract: In one embodiment, a mechanically self-leveling camera head includes a rear housing assembly, an illumination window, an illumination window retainer having a forward end for holding the illumination window a threaded coupling ring for having the rear housing assembly screwed over a rear portion of the coupling ring and the illumination window retainer screwed over a forward portion of the coupling ring, and a camera module assembly supported inside the housing.

Abstract: A ground tracking apparatus for connection to a locator or other measurement device and configured to determine position, motion, and/or orientation information is disclosed. The ground tracking apparatus may include a ground follower assembly including one or more wheels, which may be detachably coupled to a buried object locator system to capture three-dimensional positional and orientation information during a locate process, as well as provide output data or information to be integrated with maps, photographs, drawings, or other data or information.

Abstract: A transmitter system for providing current to a utility when performing a locate operation is disclosed. The transmitter system may include a tray apparatus, a transmitter module for generating an output current for provision to the utility so as to generate a magnetic field for detection by a utility locator disposed on or in the tray apparatus, and a sonde antenna node, a satellite antenna node, or a combined satellite navigation and sonde antenna node.

Abstract: A system, a method, and a computer readable media for identifying a user-initiated log file record in a log file are provided. The log file has a user-initiated log file record and a repeating pattern of log file records automatically generated by a software program. The system allows a user to identify first and second timestamp values corresponding to first and second times which identify a time interval of interest in the log file. The system further analyzes the log file to identify the user-initiated log file record having a timestamp value between the first and second timestamp values. The system further identifies the repeating pattern of log file records in the log file.

Abstract: Portable locators for detecting a buried object characterized by an electromagnetic (EM) field emission are disclosed. A locator may include a magnetic field sensor array and associated processing circuitry. A locator may further include a camera and image or video processing circuitry to process images or video received from the camera. A locator may further include a user-reconfigurable user interface (UI).

Abstract: Buried object locator systems including transmitters and associated buried object locators using phase-synchronized signals are disclosed. A transmitter may generate output current signals that are phase-synchronized such that an associated locator may receive magnetic field signals from the output current signal and determine information about the current flow based on independent phase-synchronization timing information.

Abstract: Techniques of generating metadata-based cross-platform mobile applications through user selection are disclosed. An application can be generated by receiving a selection of a data source having a set of data objects, a selection of a data object to which data set from the data source is to be populated, selections of operations to be performed on the data object, a selection of a platform, and the selection of the data object. One or more metadata elements can be generated defining interactions with the data object of the data source and the interactive object on the platforms. The application can be generated from the one or more metadata elements.

Abstract: In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least in part on the human-weighted loss function.

Abstract: The present disclosure includes an electrosurgical apparatus for treating tissue at a target site. The apparatus has a shaft with a proximal end and a distal portion, the distal portion comprising a return electrode and electrode support. There is also at least one active electrode on the shaft distal portion, which has a proximal portion and a distal portion and a plurality of aspiration apertures disposed therebetween. These apertures are fluidly connected to a fluid aspiration cavity that is located within the electrode support, and the cavity is connected with a fluid aspiration element that is located along the shaft. The plurality of apertures vary in size and are generally arranged so that the larger sized apertures are disposed towards the electrode proximal portion and the smaller sized apertures are generally located towards the electrode distal portion.

Abstract: To promote ease of use, as well as a reduction in bit error rates during extended data exchange between a coupled NFC tag/reader pair, signal strength is measured from a plurality of NFC tag antennas each positioned differently with respect to a common reader field, and differences in signal strength are used to determine an optimum positioning of the tag, or tag emulator, with respect to the reader. Alternative embodiments may include signal time of flight for determining orientation of the NFC antennas within the reader field. Information is generated by the tag, or tag emulator, and output by the tag, or tag emulator, such that a user may direct the positioning of the tag, or tag emulator, for improved communication with the reader.

Abstract: Communicating between an application and a hardware device. A method includes an application writing data to host physical memory using an application view of the memory. The method further includes mapping the data in the physical memory to a hardware driver view, usable by a hardware driver, without needing to copy the data to a different physical storage location. The method further includes mapping the data to a hardware accessible view accessible by a hardware device without needing to copy the data to a different physical storage location.

Abstract: Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.

Abstract: In one embodiment, a self-leveling camera head may include an eccentric leveling weight assembly that is supported inside an outer housing for free rotation about an axis. The leveling weight assembly may be removably coupled to a separate camera module assembly supported inside the outer housing for rotation about the axis so that its images will be “upright,” i.e. earth normal.