Abstract: Electrosurgical wands. At least some of the illustrative embodiments are electrosurgical wands having features that reduce contact of tissue with an active electrode of a wand, decrease the likelihood of clogging, and/or increase the visibility within surgical field. For example, wands in accordance with at least some embodiments may comprise standoffs, either along the outer perimeter of the active electrode, or through the main aperture in the active electrode, to reduce tissue contact. Wands in accordance with at least some embodiments may implement slots on the active electrodes to increase bubble aspiration to help keep the visual field at the surgical site clear. Wands in accordance with at least some embodiments may implement aspiration flow pathways within the wand that increase in cross-sectional area to reduce the likelihood of clogging.

Abstract: A blade assembly is disclosed. The blade assembly may include a blade having a surface defined between an upper edge and a lower edge of the blade, the lower edge being associated with a cutting edge, and a wear plate attached to the blade. The wear plate may extend along the surface and terminate short of the lower edge. The wear plate may have a plurality of accumulation members.

Abstract: The present disclosure relates to monitoring patient compliance with a dosage regimen. In some aspects, a patient unique identifier, which enables a patient to be uniquely identified and associated with a patient record, is received. A message is received. The message includes a package unique identifier that enables a package that a drug administered to the patient was stored within to be uniquely identified. The message includes at least one pair of values, wherein each pair of values corresponds to an administration event and indicates an amount of the drug administered to the patient and a time of administration of the amount of the drug to the patient. The drug administered to the patient using the package unique identifier is identified. The identity of the drug and the at least one pair of values are stored against the patient record, which includes a dosage regimen associated with the patient.

Abstract: The present disclosure relates to methods and systems suitable for use in identifying and providing personalised medicine to a patient. In some aspects, systems and method generate a co-therapy regimen for a patient suffering from a disease or condition. An identification of a co-therapy suitable to treat the disease or condition is received. A desired patient endpoint and a patient position are received, wherein the patient position is defined relative to the desired patient endpoint. A dataset relating to the patient is stored. The dataset comprises one or more patient data based on patient-related measurements. The dataset, the patient position and the desired patient endpoint are processed to generate a regimen for the co-therapy. The regimen is stored in a database.

Abstract: Portable locators for detecting buried objects and determining information therefrom based on sensing electromagnetic emissions are disclosed. In one implementation, a portable locator may include a magnetic field sensor array and associated signal processing circuitry to detect and determine information associated with the buried object, as well as a camera and image or video processing circuitry to process images or video received from the camera in conjunction with the buried object detection.

Abstract: Buried utility transmitters and associated locator devices, systems, and methods used for locating utility lines, pipes, and/or other conductors that are obscured from view are disclosed. In one embodiment a buried utility transmitter includes a module generating an output current for provision to the utility so as to generate a magnetic field for detection by a utility locator, with the output current signal having modulated signaling. The transmitter system may include a tray apparatus configured to be removably dockable to the transmitter module or element or a body or frame of the transmitter system.

Abstract: In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classifies based at least in part on the human-weighted loss function.

Abstract: In one embodiment, a mechanically self-leveling camera head includes a rear housing assembly, an illumination window, an illumination window retainer having a forward end for holding the illumination window a threaded coupling ring for having the rear housing assembly screwed over a rear portion of the coupling ring and the illumination window retainer screwed over a forward portion of the coupling ring, and a camera module assembly supported inside the housing.

Abstract: Controlling conductive fluid flow during an electrosurgical procedure. At least some of the example embodiments are methods including: flowing conductive fluid from a source lumen to a suction lumen of an electrosurgical wand, the flowing with the electrosurgical wand in a first orientation; sensing a change in orientation of the electrosurgical wand to a second orientation different than the first orientation; and changing a control parameter associated with the conductive fluid flow, the changing responsive to the change in orientation of the electrosurgical wand.

Abstract: A system may include a first conduit configured to form a first batch of discrete volumes of aqueous fluid separated by spacing liquid disposed between consecutive volumes of aqueous fluid, the spacing liquid being immiscible with the aqueous fluid volumes; a second conduit, fluidically coupled to the first conduit, the second conduit configured to statically hold the first batch of discrete volumes of aqueous fluid; and a third conduit configured to receive the first batch of discrete volumes of aqueous fluid from the second conduit. The third conduit can be configured to transfer the discrete volumes of aqueous fluid of the first batch for downstream processing.

Abstract: In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least its part on the human-weighted loss function.

Abstract: The invention relates to an apparatus for stacking battery plates comprising a delivery conveyor for supplying battery plates sequentially along a delivery path. The delivery conveyor includes a plurality of spaced apart plate carriers each configured to support at least one battery plate in use, the plate carriers defining a series of gaps between adjacent plate carriers, wherein each gap is larger than the battery plate. The apparatus further includes a stop mechanism, configured to selectively intercept the delivery path at a plurality of indexed stop positions without impeding the delivery conveyor; wherein when the stop mechanism intercepts the delivery path at a selected one of the stop positions in use, it interrupts the movement of the battery plates on the delivery conveyor causing the battery plate(s) to move off the respective plate carrier and pass through the subsequent gap of the conveyor.

Abstract: Self-leveling inspection system methods and devices for use in inspecting buried pipes or other cavities are disclosed. A camera head may include an image sensor, an orientation sensing module, and an image processing module with programming to adjust an image or video provided from the image sensor, based at least in part on information provided from the orientation sensor.

Abstract: A camera controller platform for use with a pipe inspection system is disclosed. The platform is configured for the rapid mounting and connection of an electronic computing device such as a laptop computer for providing display and/or virtual control interface functions in conjunction with an electronics module. An additional user interface, which may include a manual user interface device, may be coupled to the electronics module. Alternatively, a plurality of virtual controls may be supported by a software application on the electronic computing device, which may be connected to the camera controller platform by a USB or other interface bus.

Abstract: A transmitter system for providing current to a utility when performing a locate operation is disclosed. The transmitter system may include a tray apparatus, a transmitter module for generating an output current for provision to the utility so as to generate a magnetic field for detection by a utility locator disposed on or in the tray apparatus, and a sonde antenna node, a satellite antenna node, or a combined satellite navigation and sonde antenna node.

Abstract: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.

Abstract: A high-Q human-portable, battery-powered self-correcting tunable transmitter apparatus for inducing alternating currents in buried conductors to facilitate their location is disclosed.

Abstract: The present teachings relate to methods, systems, and kits for analyzing a sample containing a glycopeptide of interest that can subject the glycopeptide of interest to a plurality of parallel deglycosylation reactions that differentially cleave the glycan, with the various products resulting from the deglycosylation reactions being differentially labeled (e.g., with isobaric and/or isomeric labeling reagents) to thereby produce labeled glycopeptides or labeled fragments of the glycopeptides. The products of the various deglycosylation reactions can then be mixed together and subject to LC-MS/MS using a single injection of the mixture. In accordance with various aspects, by associating the resulting mass spectral data with a particular deglycosylation reaction (e.g., based on the presence in the MS/MS data of product reporter ions associated with the particular differential labels), the methods and systems described herein can aid in the identification of the glycan structure.

Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: A method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The discrete volumes are separated from one another by a liquid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.