Abstract: The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The invention also relates to the use of the compositions comprising the engineered amylase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered amylase polypeptides, as well as methods for making the engineered polynucleotides and amylase polypeptides.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: A method and system for deploying an application from a deployment source to a device may include determining if the application is available for deployment to the device from a plurality of deployment sources, upon determining that the application is available for deployment from the plurality of deployment sources, identifying one of the plurality of deployment sources as a preferred deployment source for deploying the application; and deploying the application from the preferred deployment source to the device. Deploying the application may include installing the application, loading one or more user interface elements associated with the application and activating the application.

Abstract: A method for manufacturing electrically conductive structures, preferably conductive pathway structures using laser beams on a non-conductive carrier (LDS method), wherein a non-conductive carrier material is provided which contains at least one inorganic metal phosphate compound and at least one stabiliser finely distributed or dissolved therein, the carrier material is irradiated in regions by laser beams generating the electrically conductive structures in the irradiated regions.

Abstract: The invention relates to a process for producing copper(II) hydroxide phosphate from a copper(II) compound and phosphoric acid, to a copper(II) hydroxide phosphate obtainable by this process and to the use of an additive in the production of copper(II) hydroxide phosphate.

Abstract: A joystick assembly for a working machine having a working arm includes a controller configured to control a plurality of machine functions, a first electronic joystick in communication with the controller, and actuators in communication with the controller. Each actuator is configured to actuate a function associated with the working arm. The first electronic joystick comprises four axes of movement, and the first electronic joystick is configured to transmit electronic signals to the controller in response to being displaced along an axis from a neutral position. The controller is configured to receive the electronic signals from the first electronic joystick, and to transmit an electrical signal to one or more actuators to actuate the actuators. The joystick assembly is configured such that the controller actuates a different actuator for controlling a different function associated with the working arm, dependent upon the axis of displacement of the first electronic joystick.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: An apparatus includes a machine for manufacturing a product from one or more input materials, with the machine including at least a sensor, a control panel, and a switch through which operation of the machine can be stopped. The apparatus further includes a physical display device and a computing device communicationally coupled to both the machine and the physical display device, the computing device causing the physical display device to display user interface that has a first portion displaying an availability indicator, a second portion displaying a performance indicator and a third portion displaying a quality indicator. The computing device can determine the availability indicator, the performance indicator and the quality indicator from data received from the machine and from the operator thereof. Restarting of the machine can be prevented until a reason for the machine's stoppage is received, with the reason being optionally computer-validated to enable restart.

Abstract: A working machine has a body and a moveable element. The moveable element is moveable relative to the body. A camera captures an image of at least a portion of the moveable element. A processor executes a machine learning algorithm trained to determine a position of a moveable element from an image of the moveable element. The machine learning algorithm receives the image from the camera and determines the position of the moveable element in the image.

Abstract: A training machine to generate training data for supervised machine learning. The training machine is a working machine with a camera, a sensor, a body, and a moveable element moveable relative to the body. Training data is generated by capturing images, using the camera of at least a portion of the moveable element; and determining, using the sensor, sensor data which indicates the position of the moveable element in the image. The training data is used to train a machine learning algorithm to determine a position of a moveable element based on an image of at least a portion of the moveable element, without the need for corresponding sensor data.

Abstract: A dynamic lead outreach engine can dynamically determine a next consumer interaction for a lead. The dynamic lead outreach engine can include a next consumer interaction module that employs artificial intelligence techniques to predict a next consumer interaction based on lead metadata, an outreach template and past consumer interactions. In this way, the dynamic lead outreach engine can facilitate applying a variety of outreach approaches when initiating consumer interactions with leads.

Abstract: A method of encoding a variable, which may have a plurality of different states, using an integrated circuit comprising a physical unclonable function module. The method comprises using the physical unclonable function module to generate a fingerprint value deterministically dependent on one or more physical fabrication properties of the integrated circuit; generating a first encoding value using the fingerprint value; generating a second encoding value using the fingerprint value; and encoding said variable using said encoding values.

Abstract: The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: A method for executing multipath communication at a target communication device, includes obtaining, from a source communication device, plurality of data packets via two or more different paths, where header of each data packet comprises packet information which is indicative of association among the plurality of data packets. The packet information in each data packet at source communication device is same as packet information in each data packet at target communication device irrespective of different radio access technologies, communication protocols, or radio links used in the two or more different paths. The plurality of data packets includes different data packets having different payload or duplicate data packets having a copy of same payload. The method further includes identifying first set of data packets received via first path and second set of data packets received via second path based on the packet information.

Abstract: The present disclosure relates to methods for reducing the oxidation level of cysteine residues in recombinant polypeptides such as anti-IL-17 antibodies during cell culture (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of recombinant polypeptides such as anti-IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab. Also provided are purified preparations of recombinant polypeptides produced by such methods wherein the level of active recombinant polypeptide in the preparation is high.

Abstract: A method and system for deploying an application from a deployment source to a device may include determining if the application is available for deployment to the device from a plurality of deployment sources, upon determining that the application is available for deployment from the plurality of deployment sources, identifying one of the plurality of deployment sources as a preferred deployment source for deploying the application; and deploying the application from the preferred deployment source to the device. Deploying the application may include installing the application, loading one or more user interface elements associated with the application and activating the application.

Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The present invention provides engineered ?-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with ?-glucose linkages.