Abstract: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.

Abstract: The present invention provides novel supersonic compressors comprising novel supersonic compressor rotors. The supersonic compressor rotors are designed to operate at very high rotational speed wherein the velocity of the gas entering the supersonic compressor rotor is greater than the local speed of sound in the gas, hence the descriptor “supersonic”. The new supersonic compressors comprise at least one supersonic compressor rotor defining an inner cylindrical cavity and an outer rotor rim and at least one radial flow channel allowing fluid communication between the inner cylindrical cavity and the outer rotor rim, said radial flow channel comprising a supersonic compression ramp. The novel supersonic compressor rotors are expected to enhance the performance of supersonic compressors comprising them, and to provide for greater design versatility in systems comprising such novel supersonic compressors.

Abstract: Embodiments of the invention are directed to a portable grinding apparatus comprising: a frame; a boring bar operatively coupled to the frame; and a grinding assembly operatively coupled to the boring bar, wherein the grinding assembly is adjustable in one or more axes by adjusting the frame or the grinding assembly for grinding a component secured to the frame.

Abstract: Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent —N? or —C?; B is a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6). wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical; and R is (a) a radical of formula R1R2CHNH—Y-L1-X1—(CH2)z— or (b) a radical of formula R-L1-Y1—(CH2)z—.

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

Abstract: Embodiments relate to methods and systems for building representations of related subjects. User instructions may be received via a computer system that relate identifying information relating to a subject (e.g., an individual, group and/or event) to a node being associated therewith. Nodes in different accounts may be compared and matched based on identifying information associated with the nodes. Characteristics of one of the matched nodes may be added or modified based on characteristics of another of the matched nodes. A user may be notified of a potential match, a match, and/or node characteristics additions and/or modifications.

Abstract: Compounds of formula (I) inhibit HDAC activity: wherein A, B and D independently represent ?C— or ?N—; W is a divalent radical —CH?CH— or CH2CH2—; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.

Abstract: Controlling the formation of crystalline hydrates in various fluid systems, most notably, gas and oil transmission pipeline systems by contacting the systems with certain polymers or polymers associated with solid particles. The polymers useful are chelating polymers capable of interacting with charged gaseous molecules such as carbon dioxide, by removing the carbon dioxide, or more practically by scavenging for the carbon dioxide, to prevent the methane or ethane hydrate structures from forming since they require carbon dioxide to stabilize their structures.

Abstract: Disclosed is an ejection device for an inkjet printer that includes an ejection chip having a substrate and at least one fluid ejecting element. The ejection device further includes a fluidic structure configured over the ejection chip. The fluidic structure includes a nozzle plate composed of an organic material and includes a plurality of nozzles. The fluidic structure further includes a flow feature layer configured in between the ejection chip and the nozzle plate. The flow feature layer is composed of an organic material and includes a plurality of flow features. Furthermore, the fluidic structure includes a liner layer encapsulating the nozzle plate. The liner layer further at least partially encapsulates each flow feature of the plurality of flow features. The liner layer is composed of an inorganic material. Further disclosed is a method for fabricating the ejection device.

Abstract: Embodiments relate to methods and systems for building representations of related subjects. The representations may include a plurality of nodes, each being associated with a subject. Users may be able to access records and/or source documents related to a plurality of subjects and add or modify node characteristics based thereon. Users may interact with (e.g., by adding to or modifying) documents, files, and/or records and may also make other changes or additions to nodes in the system. A process may then identify what other users may be interested in such interaction and why. For example, a score may be associated with the interaction and other users based on factors such as whether the users have linked to the document, file or record and/or the node the interaction may apply to. Interacting users, identified users, and interaction details may be stored in a database. Identified users may be notified of the interaction.

Abstract: A method of generating radiation comprises: manufacturing a structure comprising a substrate supporting a layer of InGaAs, InGaAsP, or InGaAlAs material doped with a dopant, said manufacturing comprising growing said layer such that said dopant is incorporated in said layer during growth of the layer; illuminating a portion of a surface of the structure with radiation having photon energies greater than or equal to a band gap of the doped InGaAs, InGaAsP, or InGaAlAs material so as to create electron-hole pairs in the layer of doped material; and accelerating the electrons and holes of said pairs with an electric field so as to generate radiation. In certain embodiments the dopant is Fe. Corresponding radiation detecting apparatus, spectroscopy systems, and antennas are described.

Abstract: The present invention relates to a process for preparing a nutritional, therapeutic or organoleptic product by growing non-recombinant yeast under aerobic conditions, in a medium that includes crude glycerol, as one possible carbon source to produce a yeast product. The yeast product can be processed to obtain such nutritional, therapeutic or organoleptic products as yeast paste, yeast metabolites, carbohydrates, proteins, functional proteins, nucleotides, yeast autolysates, yeast extract, yeast cell walls, beta-glucans, mannans or a product derived from a mineralized yeast product.

Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; Y is a bond, —C(?O), —S(?O)2—, —C(?O)O—, —C(O)NR3—, —C(?S)—NR3, —C(?NH)NR3 or —S(?O)2NR3— wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n and p are independently 0 or 1, Q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —X2-Q1- or -Q1-X2— wherein X2 is —O—, S— or NRA— wherein RA is hydrogen or optionally substituted C1-C3 alkyl, and Q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic r

Abstract: Compounds of formula (I), inhibit HDAC activity: wherein A, B and D independently represent ?CH— or ?N—; W is —CH?CH— Or —CH2CH2—; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R2 and R3 are selected from the side chains of a natural or non-natural alpha amino acid, provided that neither R2 nor R3 is hydrogen, or R2 and R3, taken together with the carbon to which they are attached, form a 3-6 membered saturated cycloalkyl or heterocyclyl ring; Y is a bond, —C(C?O)—, —S(?O)2—, —C(C?O)O—, —C(C?O)NR?—, —C(?S)—NR?, —C(?NH)NR? or —S(?O)2NR— wherein R? is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)(Alk2)p— wherein in, n, p, Q, AIk1 and AIk2 are as defined in the claims; X1 represents a bond; —C(?O); or —S(?O)2—; —NR4C(?O)—, —C(C?O)NR4—, —NR4C(?O)NR5—, —NR4S(?O)2—, or —S(?O)2NR4— wherein R4 and R5 are independently hydrogen or optionally substituted C1

Abstract: A process and apparatus for separating a feed containing hydrogen, carbon monoxide, methane, and optionally nitrogen to form a product gas having a desired H2:CO molar ratio and optionally a hydrogen product gas and a carbon monoxide product gas. The feed is partially condensed to form a hydrogen-enriched vapor fraction and a carbon monoxide-enriched liquid fraction. The hydrogen-enriched vapor fraction and carbon monoxide-enriched liquid fraction are combined in a regulated manner to form an admixture, which is cryogenically separated to form the product mixture having the desired H2:CO molar ratio.

Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:

Abstract: Covalent conjugates of an ?,?-disubstituted glycine ester and a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid and the ?,?-disubstituted glycine ester is conjugated to the modulator at a position remote from the binding interface between the inhibitor and the target enzyme or receptor pass into cells and the active acid hydrolysis product accumulates within the cells.

Abstract: A supersonic compressor rotor. The supersonic compressor rotor includes a rotor disk that includes an upstream surface, a downstream surface, and a radially outer surface that extends generally axially between the upstream surface and the downstream surface. The radially outer surface includes an inlet surface, an outlet surface, and a transition surface that extends between the inlet surface and the outlet surface. A plurality of vanes are coupled to the radially outer surface. Adjacent vanes form a pair and are oriented such that a flow channel is defined between each pair of adjacent vanes. The flow channel extends between an inlet opening and an outlet opening. The inlet surface defines an inlet plane that extends between the inlet opening and the transition surface. The outlet surface defines an outlet plane that extends between the outlet opening and the transition surface that is not parallel to the inlet plane.

Abstract: The present invention relates to an area suitable for equestrian use. The area comprises an upper, equestrian surface layer, and a sub-surface support layer which includes a plurality of laterally arranged load bearing structural modules. Each module comprises a top wall and a bottom wall spaced therefrom by one or more supporting elements so as to define an interior volume between the top and bottom walls, and is provided with at least one aperture to permit the flow of water into and out of the volume. There is a system for retaining water within at least some modules in the sub-surface support layer. A water permeable layer that is impermeable to solid particles of the upper, equestrian surface layer is provided between the structural modules and the equestrian surface layer. A wicking system is in fluid communication with the interior volumes of at least some of the modules and have portions extending upwardly to transfer water to the upper, equestrian surface layer from the sub-surface support layer.

Abstract: A die attach composition is used for bonding a silicon chip on a flat substrate. The die attach composition includes a cross-linkable epoxy resin having a rigid backbone, an epoxy siloxane resin, a fumed silica filler, an amine curing agent, and a silane coupling agent. The die attach composition is particularly useful in bonding silicon heater chips on flat ceramic substrate in forming an inkjet printhead assembly. The die attach composition allows accurate placement of silicon heater chips on flat ceramic substrate and exhibits good ink resistance.