Patents by Inventor David Graham

David Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases
    Patent number: 8637547
    Abstract: Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent ?C— or ?N—; W is a divalent radical —CH?CH— or CH2CH2—; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: January 28, 2014
    Assignee: Chroma Therapeutics Ltd.
    Inventors: Alan Hornsby Davidson, David Charles Festus Moffat, Francesca Ann Day, Alistair David Graham Donald
  • ACTIVE ELECTRONICALLY SCANNED ARRAY ANTENNA FOR HEMISPHERICAL SCAN COVERAGE
    Publication number: 20130335269
    Abstract: An antenna architecture for hemispherically-scanning active electronically scanned arrays (AESA). The antenna architecture utilizes variable diameter disks of antenna elements configured in a conical implementation. The antenna elements are oriented such that the element boresight is normal to the surface of the conical structure. Beamforming takes place on each disk first, and them separately in combining the signals from each disk, thereby reducing complexity. The antenna optionally utilizes disks of antenna elements of the same diameter to form a cylindrical antenna, which when combined with a conical configuration create enhanced sectors while maintaining a hemispherical coverage capability. Further, use of two conical configurations can produce a fully spherical coverage capability.
    Type: Application
    Filed: August 20, 2013
    Publication date: December 19, 2013
    Applicant: SRC, Inc.
    Inventors: Daniel R. Culkin, Timothy David Graham
  • ENZYME INHIBITORS
    Publication number: 20130303576
    Abstract: Compounds of formula (I), inhibit HDAC activity: wherein A, B and D independently represent ?CH— or ?N—; W is —CH?CH—Or —CH2CH2—; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R2 and R3 are selected from the side chains of a natural or non-natural alpha amino acid, provided that neither R2 nor R3 is hydrogen, or R2 and R3, taken together with the carbon to which they are attached, form a 3-6 membered saturated cycloalkyl or heterocyclyl ring; Y is a bond, —C(?O)—, —S(?O)2—, —C(?O)O—, —C(?O)NR?—, —C(?S)—NR?, —C(?NH)NR? or —S(?O)2NR— wherein R? is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 14, 2013
    Inventors: Alastair David Graham Donald, David Festus Charles Moffat, Andrew James Belfield, Carl Leslie North, Stewart Andrew Wayne Jones
  • EJECTION DEVICES FOR INKJET PRINTERS AND METHOD FOR FABRICATING EJECTION DEVICES
    Publication number: 20130284694
    Abstract: Disclosed is an ejection device for an inkjet printer that includes an ejection chip having a substrate and at least one fluid ejecting element. The ejection device further includes a fluidic structure configured over the ejection chip. The fluidic structure includes a nozzle plate composed of an organic material and includes a plurality of nozzles. The fluidic structure further includes a flow feature layer configured in between the ejection chip and the nozzle plate. The flow feature layer is composed of an organic material and includes a plurality of flow features. Furthermore, the fluidic structure includes a liner layer encapsulating the nozzle plate. The liner layer further at least partially encapsulates each flow feature of the plurality of flow features. The liner layer is composed of an inorganic material. Further disclosed is a method for fabricating the ejection device.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Xiaorong CAI, Jiandong FANG, Xiaoming WU, Elaine Yeap MONEY, Eunki HONG, Yimin GUAN, Burton JOYNER, II, Sean Terrance WEAVER, David GRAHAM, Zach REITMEIER
  • Active electronically scanned array antenna for hemispherical scan coverage
    Patent number: 8547275
    Abstract: An antenna architecture for hemispherically-scanning active electronically scanned arrays (AESA). The antenna architecture utilizes variable diameter disks of antenna elements configured in a conical implementation. The antenna elements are oriented such that the element boresight is normal to the surface of the conical structure. Beamforming takes place on each disk first, and them separately in combining the signals from each disk, thereby reducing complexity. The antenna optionally utilizes disks of antenna elements of the same diameter to form a cylindrical antenna, which when combined with a conical configuration create enhanced sectors while maintaining a hemispherical coverage capability. Further, use of two conical configurations can produce a fully spherical coverage capability.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: October 1, 2013
    Assignee: SRC, Inc.
    Inventors: Daniel R. Culkin, Timothy David Graham
  • COLLABORATIVE SYSTEMS AND METHODS FOR CONSTRUCTING REPRESENTATIONS OF DATA
    Publication number: 20130238653
    Abstract: Embodiments relate to methods and systems for building representations of related subjects. User instructions may be received via a computer system that relate identifying information relating to a subject (e.g., an individual, group and/or event) to a node being associated therewith. Nodes in different accounts may be compared and matched based on identifying information associated with the nodes. Characteristics of one of the matched nodes may be added or modified based on characteristics of another of the matched nodes. A user may be notified of a potential match, a match, and/or node characteristics additions and/or modifications.
    Type: Application
    Filed: December 18, 2012
    Publication date: September 12, 2013
    Applicant: ANCESTRY.COM OPERATIONS, INC.
    Inventors: DAVID GRAHAM, MARK ALLEN, MIKE SMELTZER, BARRY WATTS, PRESTON THAYNE, DOUG REID, GRANT PARKINSON
  • Anti-Viral Azide Containing Compounds
    Publication number: 20130209550
    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.
    Type: Application
    Filed: July 28, 2011
    Publication date: August 15, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Brian Agnew, David Graham, Upinder Singh, Scott Grecian
  • Harnesses
    Patent number: 8474457
    Abstract: A harness for use with breathing apparatus has: a flexible hip plate 12 and a flexible bandolier-style shoulder panel 14, linked together by a strap 15, and a waist belt 16 fastenable by a sprung fastener. In use, the flexible hip plate 12 rests against the hip of a user (the left hip in this example), the waist belt is fitted around the waist of the user, and the shoulder panel 14 rests against the shoulder opposite to the hip against which the flexible plate is resting (the right shoulder in this example). At least the bandolier-style panel 14, and optionally also the hip plate 12 of the harness 10, are made of a resilient material which, though flexible, allows the harness substantially to retain its operational configuration even when not being worn.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: July 2, 2013
    Assignee: Draeger Safety UK Limited
    Inventors: Aaron Chapman, David Graham Storey, Paul Townsend
  • BENZAMIDE DERIVATIVES AND THEIR USE AS HSP90 INHIBTORS
    Publication number: 20130143926
    Abstract: The invention provides a compound which is (a) a phenylamide derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate, prodrug or solvate thereof: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.
    Type: Application
    Filed: June 10, 2011
    Publication date: June 6, 2013
    Inventors: Alastair David Graham Donald, Joanne McDermott, Sanjay Ratilal Patel, David Festus Charles Moffat
  • Enzyme Inhibitors
    Publication number: 20130116318
    Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:
    Type: Application
    Filed: December 1, 2010
    Publication date: May 9, 2013
    Applicant: Chroma Therapeutics Ltd.
    Inventors: Alan Hornsby Davidson, Sanjay Ratilal Patel, Francesca Ann Mazzei, Stephen John Davies, Alan Hastings Drummond, David Festus Moffat, Kenneth William John Baker, Alistair David Graham Donald
  • Pyrophoric material
    Patent number: 8430982
    Abstract: A pyrophoric material comprises a pyrophoric metal coated onto a wire mesh substrate. Iron and nickel are the preferred metals and a steel wire mesh is suitable. A process for making the pyrophoric material involves spraying an alloy of iron and/or nickel with aluminium onto a mesh using a high velocity oxy-fuel (HVOF) process following by leaching out at least a proportion of the aluminium by treatment with an alkaline solution. The product has application as a supported catalyst or as either an ignition medium or as a flare material in military countermeasures in which applications it is capable of burning at a high temperature.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: April 30, 2013
    Assignee: The Secretary of State for Defence
    Inventors: James Dominic Callaway, James Neil Towning, Raymond Cook, Paul Smith, David Graham McCartney, Andrew J. Horlock
  • Formulations for environmentally friendly photoresist film layers
    Patent number: 8394575
    Abstract: Environmentally friendly thick film layers for a micro-fluid ejection head and micro-fluid ejection heads are disclosed. The environmentally friendly thick film layer includes a negative photoresist layer derived from a composition comprising a multi-functional epoxy compound, a low molecular weight polymeric difunctional epoxy compound, a monomeric difunctional epoxy compound, a methide-based photoacid generator that does not contain antimony, a chromophore and an aryl ketone solvent. Optionally the photoresist layer contains an adhesion enhancer. The negative photoresist layer is environmentally friendly and provides good resolution, well defined critical dimensions, straight side walls, and a large processing window.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: March 12, 2013
    Assignee: Lexmark International, Inc.
    Inventors: Xiaoming Wu, David Graham, Sean Weaver, Bart Mansdorf, Rich Wells, Joel Provence
  • SYSTEMS AND METHODS FOR THE ORGANIZED DISTRIBUTION OF RELATED DATA
    Publication number: 20130018844
    Abstract: Embodiments relate to methods and systems for building representations of related subjects. The representations may include a plurality of nodes, each being associated with a subject. Users may be able to access records and/or source documents related to a plurality of subjects and add or modify node characteristics based thereon. Users may be able to perform an interaction and/or modification related to a record page. Other users (e.g., users connected to the record page) may be notified of such interaction and/or modification.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 17, 2013
    Applicant: Ancestry.com Operations Inc.
    Inventors: David Graham, Mark Allen, Mike Smeltzer, Barry Watts, Preston Thayne, Doug Reid, Grant (Greg) Parkinson
  • Collaborative systems and methods for constructing representations of data
    Patent number: 8356023
    Abstract: Embodiments relate to methods and systems for building representations of related subjects. User instructions may be received via a computer system that relate identifying information relating to a subject (e.g., an individual, group and/or event) to a node being associated therewith. Nodes in different accounts may be compared and matched based on identifying information associated with the nodes. Characteristics of one of the matched nodes may be added or modified based on characteristics of another of the matched nodes. A user may be notified of a potential match, a match, and/or node characteristics additions and/or modifications.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: January 15, 2013
    Assignee: Ancestry.com Operations Inc.
    Inventors: David Graham, Mark Allen, Mike Smeltzer, Barry Watts, Preston Thayne, Doug Reid, Grant (Greg) Parkinson
  • EJECTION DEVICES FOR INKJET PRINTERS AND METHOD FOR FABRICATING EJECTION DEVICES
    Publication number: 20120274707
    Abstract: Disclosed is an ejection device for an inkjet printer that includes an ejection chip having a substrate and at least one fluid ejecting element. The ejection device further includes a fluidic structure configured over the ejection chip. The fluidic structure includes a nozzle plate composed of an organic material and includes a plurality of nozzles. The fluidic structure further includes a flow feature layer configured in between the ejection chip and the nozzle plate. The flow feature layer is composed of an organic material and includes a plurality of flow features. Furthermore, the fluidic structure includes a liner layer encapsulating the nozzle plate. The liner layer further at least partially encapsulates each flow feature of the plurality of flow features. The liner layer is composed of an inorganic material. Further disclosed is a method for fabricating the ejection device.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 1, 2012
    Inventors: Xiaorong Cai, Jiandong Fang, Xiaoming Wu, Elaine Yeap Money, Eunki Hong, Yimin Guan, Burton Joyner, II, Sean Terrance Weaver, David Graham, Zach Reitmeier
  • System and method for reduction of point of origin errors
    Patent number: 8294609
    Abstract: A method of using a discriminant analysis and Kalman filter cascade to improve the accuracy of point of origin solutions. Tracking information about a potential target is utilized by an initial discrimination function to classify the target as a projectile. Using that information, the output of a first Kalman filter is fed into an additional discrimination function to further classify the type or sub-class of the projectile. A second Kalman filter can employ type-specific information to obtain a point of origin solution with increased efficiency and accuracy.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: October 23, 2012
    Assignee: SRC, Inc.
    Inventor: Timothy David Graham
  • DIE ATTACH COMPOSITION FOR SILICON CHIP PLACEMENT ON A FLAT SUBSTRATE HAVING IMPROVED THIXOTROPIC PROPERTIES
    Publication number: 20120182355
    Abstract: A die attach composition is used for bonding a silicon chip on a flat substrate. The die attach composition includes a cross-linkable epoxy resin having a rigid backbone, an epoxy siloxane resin, a fumed silica filler, an amine curing agent, and a silane coupling agent. The die attach composition is particularly useful in bonding silicon heater chips on flat ceramic substrate in forming an inkjet printhead assembly. The die attach composition allows accurate placement of silicon heater chips on flat ceramic substrate and exhibits good ink resistance.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 19, 2012
    Inventors: David Graham, Jeanne Marie Saldanha Singh, Richard D. Wells, Joel Provence
  • Systems and methods for the organized distribution of related data
    Patent number: 8224821
    Abstract: Embodiments relate to methods and systems for building representations of related subjects. The representations may include a plurality of nodes, each being associated with a subject. Users may be able to access records and/or source documents related to a plurality of subjects and add or modify node characteristics based thereon. Users may be able to perform an interaction and/or modification related to a record page. Other users (e.g., users connected to the record page) may be notified of such interaction and/or modification.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: July 17, 2012
    Assignee: Ancestry.com Operations Inc.
    Inventors: David Graham, Mark Allen, Mike Smeltzer, Barry Watts, Preston Thayne, Doug Reid, Grant (Greg) Parkinson
  • Method and apparatus for curing a thermosetting material
    Patent number: 8211339
    Abstract: A method and apparatus for curing a thermosetting material. The method comprises heating the material with a liquid heating medium; measuring an electrical or optical property of the material with a cure sensor; and regulating the temperature of the liquid heating medium in accordance with the measured property of the material.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: July 3, 2012
    Assignee: Airbus Operations Ltd.
    Inventor: David Graham Inston
  • Seating unit with headrest
    Patent number: D680771
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: April 30, 2013
    Assignee: Steelcase Inc.
    Inventors: Mark William Spoelhof, Alan Ernest Rheault, Michael David Graham, Patrick John Crowley