Patents by Inventor David H. Sherman

David H. Sherman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10239918
    Abstract: Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: March 26, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Fengan Yu, Chuanwu Xi, Jianfeng Wu, Pamela J. Schultz, Ashootosh Tripathi, Sung Ryeol Park
  • Publication number: 20180162906
    Abstract: Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
    Type: Application
    Filed: May 26, 2016
    Publication date: June 14, 2018
    Inventors: David H. Sherman, Fengan Yu, Chuanwu Xi, Jianfeng Wu, Pamela Schultz, Ashootosh Tripathi, Sung Ryeol Park
  • Patent number: 9994885
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: June 12, 2018
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Patent number: 9803187
    Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: October 31, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ASOCIACION INSTITUTO NACIONAL DE BIODIVERSIDAD
    Inventors: David H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz
  • Patent number: 9650656
    Abstract: The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(?)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: May 16, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Shengying Li, Krithika Anand Srinivasan, Robert M. Williams, David H. Sherman
  • Patent number: 9611491
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: April 4, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ALLEGHENY-SINGER RESEARCH INSTITUTE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Patent number: 9605015
    Abstract: The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 28, 2017
    Assignee: INHA-INDUSTRY PARTNERSHIP INSTITUTE
    Inventors: Eung-Soo Kim, Kyu Boem Han, Shuangjun Lin, Dekun Kong, Linquan Bai, Zixin Deng, David H. Sherman, Mi-Jin Lee
  • Publication number: 20170044582
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Application
    Filed: January 22, 2015
    Publication date: February 16, 2017
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Patent number: 9487763
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 8, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Publication number: 20150361470
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Application
    Filed: May 15, 2015
    Publication date: December 17, 2015
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Publication number: 20150337288
    Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
    Type: Application
    Filed: May 20, 2015
    Publication date: November 26, 2015
    Inventors: David H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz
  • Publication number: 20150050704
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 19, 2015
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Publication number: 20150044735
    Abstract: The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(?)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
    Type: Application
    Filed: April 3, 2013
    Publication date: February 12, 2015
    Inventors: Shengying Li, Krithika Anand Srinivasan, Robert M. Williams, David H. Sherman
  • Publication number: 20140371436
    Abstract: The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 18, 2014
    Applicant: INHA-INDUSTRY PARTNERSHIP INSTITUTE
    Inventors: Eung-Soo Kim, Kyu Boem Han, Shuangjun Lin, Dekun Kong, Linquan Bai, Zixin Deng, David H. Sherman, Mi-Jin Lee
  • Patent number: 8815562
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: August 26, 2014
    Assignees: The Regenys of the University of Michigan, Allegheny-Singer Research Institute, Colorado State University Research Foundation
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Patent number: 8765431
    Abstract: Disclosed herein are methods of preparing alkenes from beta-hydroxy or beta-sulfate carboxylic acid or carboxylic acid derivatives using thioesterase and optionally a sulfotransferase.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: David H. Sherman, Janet L. Smith, Liangcai Gu, Jennifer Gehret
  • Publication number: 20130095533
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Application
    Filed: April 15, 2011
    Publication date: April 18, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CLORADO STATE UNIVERSITY RESEARCH FOUNDATION, ALLEGHENY-SINGER RESEARCH INSTITUTE
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Patent number: 8313936
    Abstract: The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: November 20, 2012
    Assignee: Regents of the University of Michigan
    Inventors: David H Sherman, Zachary Q Beck, Yousong Ding
  • Publication number: 20120220008
    Abstract: The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
    Type: Application
    Filed: July 22, 2009
    Publication date: August 30, 2012
    Inventors: David H Sherman, Zachary Q. Beck, Yousong Ding
  • Publication number: 20120190635
    Abstract: The present invention provides regio- and stereoselective oxidation of unactivated C—H bonds using an engineered mutant cytochrome P450 monooxygenase and an engineered substrate.
    Type: Application
    Filed: September 27, 2010
    Publication date: July 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shengying Li, David H. Sherman, John Montgomery, Mani R. Chaulagain, Allison R. Knauff