Patents by Inventor David H. Sherman

David H. Sherman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolic engineering of polyhydroxyalkanoate monomer synthases
    Patent number: 6600029
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: July 29, 2003
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Mark D. Williams, Yongquan Xue
  • Mitomycin biosynthetic gene cluster
    Publication number: 20030134398
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, as well as methods of using gene(s) within the cluster to alter biosynthesis.
    Type: Application
    Filed: September 12, 2001
    Publication date: July 17, 2003
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon
  • Mitomycin biosynthetic gene cluster
    Publication number: 20030124689
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, as well as methods of using gene(s) within the cluster to alter biosynthesis.
    Type: Application
    Filed: October 9, 2002
    Publication date: July 3, 2003
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon
  • Products encoded by a methymycin/pikromycin biosynthetic gene cluster
    Publication number: 20030087405
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: April 17, 2001
    Publication date: May 8, 2003
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Publication number: 20030073824
    Abstract: A biosynthetic gene cluster for methymycin and pikromycin as well as a biosynthetic gene cluster for desosamine is provided.
    Type: Application
    Filed: November 19, 2001
    Publication date: April 17, 2003
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • Genes encoding resistance to DNA alkylating agents
    Patent number: 6524812
    Abstract: The invention provides genes encoding resistance to DNA bioreductive alkylating or cleaving agents and methods of identifying and using those genes.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: February 25, 2003
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Paul R. August, Michael C. Flickinger
  • Mitomycin biosynthetic gene cluster
    Patent number: 6495348
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, for example, a mitomycin biosynthetic cluster from organisms such as Streptomyces, for instance, S. lavendulae, as well as methods of using gene(s) within the cluster to alter antibiotic biosynthesis and to prepare a polyketide synthase.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: December 17, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon
  • DNA encoding methymycin and pikromycin
    Publication number: 20020164742
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: May 18, 2001
    Publication date: November 7, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • Polyketide synthase encoded by a methymycin/pikromycin biosynthetic gene cluster
    Publication number: 20020110897
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: May 18, 2001
    Publication date: August 15, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Patent number: 6265202
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: July 24, 2001
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • Method for increasing production of microbial metabolites by genetic engineering
    Patent number: 5474912
    Abstract: Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of:a) identifying the gene in unaltered chromosomal DNA which encodes an enzyme that catalyzes the rate controlling step in a biosynthetic pathway in the production of increased concentration of a precursor to a core molecule which leads to the antimicrobial metabolite; andb) inserting into unaltered chromasomal DNA a genetic delivery vehicle (such as a vector, phage, or virus) which carries a gene which encodes the enzyme that catalyzes the rate controlling step in the biosynthesis in the production of a core molecule which is a precursor to the antimicrobial metabolite into unaltered chromosomal DNA, said delivery vehicle being compatible with said unaltered chromosomal DNA, the delivery vehicle being generated byinserting at least one exact or modified copy of the gene determining the rate controlling step into the compatible delivery vehicle, andinserting the delivery vehicle containing t
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: December 12, 1995
    Inventors: David H. Sherman, Wei-Shou Hu, Li-Hong Malmberg