Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Abstract: Provided herein are, inter alia, methods of treating cancer using compounds of the invention.

Abstract: Techniques for accurately predicting vehicle state errors for avoiding collisions with objects detected in an environment of a vehicle are discussed herein. A vehicle safety system can implement a model determine a representation of the vehicle usable in a scenario. The model may dynamically determine a size and/or a heading of the vehicle representation based on differences between a candidate trajectory and a current trajectory of the vehicle. The safety system can identify a potential collision between the vehicle and the object based at least in part on an overlap of the vehicle representation and an object representation.

Abstract: Systems and methods for software product deployment and/or compliance management are provided. In some embodiments, a method includes: receiving an indication of a first payload of a software deployment package; performing a first software scan of the first payload; generating a first integrity file including an indication of integrity based upon the first software scan; and triggering a transfer of the first payload and the first integrity file from a first network domain to a second network domain different from the first network domain.

Abstract: Disclosed embodiments may include a system for card authentication. The system may receive, via a user device, a voice request to activate a card associated with a customer account. The system may generate, using a first machine learning model (MLM), a voice fingerprint confidence score based on comparing a first voice in the voice request to a second voice in a stored audio file associated with a customer of the customer account. The system may generate, using a second MLM, a device authentication score based on comparing an address from the user device to a stored address of a known user device associated with the customer account. The system may determine whether the voice request is valid based at least in part on the voice fingerprint confidence score and the device authentication score. The system may activate the card based on the determination that the voice request is valid.

Abstract: Integrin ?5?1-binding polypeptides are disclosed having an amino acid sequence at least 50% identical to the amino acid sequence selected from SEQ ID NO:1-14, or selected from SEQ ID NO:11-14, not including any insertions, wherein residues 8-10 relative to the reference polypeptide are RGD, and their use for treating cancer, vascular disease, rheumatoid arthritis, and diseases associated with pathogenic angiogenesis.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.

Abstract: Designed polypeptides that bind specifically to a defined protein target are provided, as well as methods for their design and use.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.

Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Abstract: Techniques for discovering semantic meaning of data in fields included in one or more data sets, the method including: a first field having a previously-assigned label that indicates a semantic meaning of the first field; identifying a set of one or more candidate labels, for potential assignment to the first field instead of the previously-assigned label; evaluating, using a previously-determined label score and a first candidate label score, whether to assign a first candidate label to the first field, the evaluating comprising: when the first candidate label score is at least a first threshold amount greater than a previously-determined label score, presenting the first candidate label to a user by generating an interface through which the user can provide input indicating whether to assign the first candidate label to the first field instead of the previously-determined label.

Abstract: A conversation detector processes microphone signals and other sensor signals of a headphone to declare a conversation and configures a filter block to activate a transparency audio signal. It then declares an end to the conversation based on processing one or more of the microphone signals and the other sensor signals, and in response deactivates the transparency audio signal. The conversation detector monitors an idle duration in which an OVAD and a TVAD are both or simultaneously indicating no activity and declares the end to the conversation in response to the idle duration being longer than an idle threshold. Other aspects are also described and claimed.

Abstract: The subject matter described herein relates to engineered monoclonal antibodies, derived from antibodies isolated from human patients, neutralizing a SARS-CoV-2 virus, its variants, or related coronaviruses.

Abstract: A device for electrically connecting with and holding organoids includes a substrate and a multielectrode array (MEA) attached to said substrate. The MEA includes an electrical bus attached to the substrate, and a plurality of leaflets each having a first end pivotably connected to the electrical bus while remaining portions thereof are free to move relative to the substrate while remaining connected and pivoting at each first end. Each leaflet of the plurality of leaflets includes an electrical wire embedded therein that extends from each respective leaflet into the electrical bus. The MEA has a size that is suitable to electrically connect to and hold an organoid that is between 250 ?m to 2 cm while at least one leaflet of the plurality of leaflets is pivoted up away from the substrate so as to securely hold the organoid in place and form a three-dimensional electrical connection with the organoid.

Abstract: A method of increasing paper strength is provided. The method includes adding a lignin-based compound to a pulp slurry: and adding a cationic polymer to the pulp slurry. When added to a pulp slurry. the combination of a lignin-based compound and a cationic polymer produce a comprehensive paper strength increase.

Abstract: A surface cleaning apparatus includes a recovery tank, a suction nozzle in fluid communication with the recovery tank, and a suction source in fluid communication with the suction nozzle and the recovery tank to generate a working air path to transport debris-containing fluid including air and liquid from the suction nozzle into the recovery tank. An air/liquid separator can be provided within the recovery tank for separating liquid from air in the debris-containing fluid.

Abstract: In some implementations, a device may transmit a buffer monitoring request message, wherein the buffer monitoring request message indicates a threshold time. The device may receive a buffer monitoring response message, wherein the buffer monitoring response message indicates one or more data radio bearers (DRBs) having buffers that exceed a data threshold for a time longer than the threshold time, and wherein the buffer monitoring response message indicates respective buffer sizes. The device may receive a measurement report of a user equipment (UE) associated with a buffer size among the respective buffer sizes, wherein the measurement report is associated with secondary node (SN) candidates. The device may establish, based on the measurement report, a New Radio dual connectivity (NR-DC) for the UE by adding an SN from the SN candidates.