Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R7 are as defined herein, as well as compositions comprising at least one Substituted Thiophene Derivative, and methods of using the Substituted Thiophene Derivatives for treating or preventing cancer in a patient.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: Systems and methods for batteries comprising a cathode, an electrolyte, and an anode, wherein sacrificial salts and prelithiation reagents are added to the cathode as functional additives for electrochemical prelithiation.

Abstract: The present disclosure is directed to photonic wavelength division multiplexing (WDM) receivers with polarization diversity and/or low reflectance. In embodiments, a WDM receiver is provided with a splitter, a plurality of waveguides and a plurality of photodetectors in series. The waveguides having particular equal path lengths relationship from the splitter to respective ones of the photodetectors. In other embodiments, the WDM receiver is provided with a splitter, a looped waveguide, a plurality of photodetectors, and a plurality of variable optical attenuators (VOAs). The VOAs are configured to suppress reflection of signal beams back to the transmitter. In various embodiments, the WDM receiver is a receiver sub-assembly of a silicon photonic transceiver disposed in a silicon package. Other embodiments may be described and/or claimed.

Abstract: Foldable intraocular lens (IOL) having a total dioptric power and comprising an optic portion (12) having main anterior and posterior optical surfaces, and incorporating an internal optical feature (13) positioned between the main anterior and posterior optical surfaces are described. The optic portion has a diameter of greater than 6.0 mm and a maximum central cross-sectional area of less than 2 mm2 along the diameter, and the internal optical feature positively contributes to the total dioptric power of the intraocular lens.

Abstract: A system obtains a first training data set comprising labeled speech data or both labeled and unlabeled data corresponding to a high-resource data set as well as latent speech representations based on the first training data set. The system trains a machine learning model on the first training data set to learn phonetically aware speech representations corresponding to the first training data set. The system applies the latent speech representations to a transformer context network to generate contextual representations. The system aligns each of the contextual representations with a phoneme label to generate phonetically-aware contextual representations. The system causes a refinement engine to further refine the machine learning model.

Abstract: The present invention provides crystalline forms of (6S,7S)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (“Compound I”). Also provided are related pharmaceutical compositions, methods of preparation, and methods of treating hypertrophic cardiomyopathy (HCM), heart failure with preserved ejection fraction (HFpEF), diastolic dysfunction, left ventricular hypertrophy, and other cardiac diseases.

Abstract: Disclosed herein is one or more subtilisin variant useful for cleaning applications and in methods of cleaning. One embodiment is directed to one or more subtilisin variant, including one or more Bacillus sp. subtilisin polypeptide variant, and one or more cleaning composition comprising one or more such variant.

Abstract: The present inhibitory polypeptides/peptides are derived from an envelope (E) protein of a coronavirus (e.g., human coronaviruses such as SARS-CoV-2). The polypeptides/peptides against coronaviruses can be used to treat or prevent infection by a coronavirus in a subject.

Abstract: A device determines a periodicity of downstream traffic destined for a User Equipment device (UE) and sets a value of at least one Discontinuous Reception (DRx) cycle length parameter to compensate for the determined periodicity of the downstream traffic. The device generates UE DRx instructions that include the at least one DRx cycle length parameter and sends the UE DRx instructions to the UE for implementing DRx at the UE.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: The problem of lost circulation is pertinent to the oil industry. To prevent fluid loss, a lost circulation material (LCM), or more generally, a plugging material, can be used to effectively plug the fractures in the rock formation. If the fractures are in the production zone, it is also ideal to unplug them when the drilling operation is complete. Therefore, a material engineered to degrade after a desired period would be useful. In examples, a plugging material has been developed by gelling an oil-based fluid using a low molecular weight gelator, dibenzylidene sorbitol (DBS). DBS gels are robust and show plugging behavior. DBS is shown to chemically degrade in presence of an acid. Hence, a self-degrading gel can be synthesized by incorporating an acid into the system. Further, by varying the type and concentration of the acid, the degradation time of the gel can be controlled.

Abstract: Disclosed embodiments may include a system for card authentication. The system may receive, via a user device, a voice request to activate a card associated with a customer account. The system may generate, using a first machine learning model (MLM), a voice fingerprint confidence score based on comparing a first voice in the voice request to a second voice in a stored audio file associated with a customer of the customer account. The system may generate, using a second MLM, a device authentication score based on comparing an address from the user device to a stored address of a known user device associated with the customer account. The system may determine whether the voice request is valid based at least in part on the voice fingerprint confidence score and the device authentication score. The system may activate the card based on the determination that the voice request is valid.

Abstract: Techniques for discovering semantic meaning of data in fields included in one or more data sets, the method including: a first field having a previously-assigned label that indicates a semantic meaning of the first field; identifying a set of one or more candidate labels, for potential assignment to the first field instead of the previously-assigned label; evaluating, using a previously-determined label score and a first candidate label score, whether to assign a first candidate label to the first field, the evaluating comprising: when the first candidate label score is at least a first threshold amount greater than a previously-determined label score, presenting the first candidate label to a user by generating an interface through which the user can provide input indicating whether to assign the first candidate label to the first field instead of the previously-determined label.

Abstract: In some implementations, a device may transmit a buffer monitoring request message, wherein the buffer monitoring request message indicates a threshold time. The device may receive a buffer monitoring response message, wherein the buffer monitoring response message indicates one or more data radio bearers (DRBs) having buffers that exceed a data threshold for a time longer than the threshold time, and wherein the buffer monitoring response message indicates respective buffer sizes. The device may receive a measurement report of a user equipment (UE) associated with a buffer size among the respective buffer sizes, wherein the measurement report is associated with secondary node (SN) candidates. The device may establish, based on the measurement report, a New Radio dual connectivity (NR-DC) for the UE by adding an SN from the SN candidates.

Abstract: Various embodiments herein provide methods to obtain corneoscleral surface profiles from optical coherence tomography (OCT) data and/or another three-dimensional (3D) volumetric scan of the eye. The OCT data may be obtained using radial scans. The limbal junction may be estimated from the radial profiles of the central moments of OCT axial scans. The external topographic limbus may be located using curve fitting of a scleral topography map and/or corneal topography map. Elevation profiles and topographic maps of the anterior eye, referenced to the best-fit topographic limbal circle and its associated plane and central axis, are constructed. The reference coordinate allows the generation of maps and radial profiles for surface elevation, axial radius, and tangential radius. Using ellipsoidal fitting, the corneal height, corneal principal meridians and associated radii of curvature, and scleral principal meridians and associated radii of curvature, are calculated.

Abstract: Provided in this disclosure are formulations and methods including antimicrobial peptides and at least one antibiotic that can treat or prevent microbial films when applied on an object. Also provided in this disclosure are formulations and methods including antimicrobial peptides and at least one antibiotic that can treat or prevent microbial films when administered to a subject. Also provided in this disclosure are formulations and methods including administering antimicrobial peptides and at least one antibiotic that can improve the survivability of subjects with bacterial infections. Also provided in this disclosure are formulations and methods including administering antimicrobial peptides and at least one antibiotic that can improve the survivability of subjects with periprosthetic joint infection.

Abstract: A system may include a mobile integrated access and backhaul (M-IAB) base station configured to serve a set of user equipment (UE) devices; and a parent base station configured to establish a backhaul link for the M-IAB base station. The parent base station may be further configured to provide configuration data to the M-IAB base station that causes the M-IAB base station to report when a triggering condition for preparing a handover to a target parent node is satisfied; detect that the triggering condition is satisfied; and send, in response, a request to the target parent node to prepare the handover. The M-IAB base station may be further configured to detect that a handover condition is satisfied and send a handover request to the target parent node using the configuration data, in response to detecting that the handover condition is satisfied.

Abstract: A redox device of a metal-air flow battery includes a container, a rod inserted into and electrically insulated from the container, a net connected to and surrounding the rod, a power supply, and an ultrasonic module. The container, the rod, and the net are electrically conductive, respectively. The net moves away from the rod gradually in a spiral manner. The container receives an electrolyte solution containing a product originated from the metal-air flow battery. The net is immersed in the electrolyte solution. The power supply is electrically connected to the container, the rod, and the net to form an electric loop via the electrolyte solution. The power supply provides a pulse current to the electric loop to electrochemically deposit metal from the electrolyte solution on the net. The ultrasonic module provides vibrations to the container to shake off metal from the net and suspend the metal in the electrolyte solution.

Abstract: A network device obtains a Physical Layer Cell Identifier (PCI) pool for allocating to ad-hoc mobile Integrated Access and Backhaul (IAB) nodes traversing a wireless network. The network device selects a first PCI for allocation to a first ad-hoc mobile IAB node located in the wireless network based on PCIs contained in the PCI pool, and allocates the first PCI to the first ad-hoc mobile IAB node. The network device pushes the allocated first PCI to the first ad-hoc mobile IAB node for use by the first ad-hoc mobile IAB node to establish User Equipment (UE) wireless access to the wireless network via wireless backhaul.