Abstract: A system includes a laser system and a controller. The laser system includes a laser configured to emit electromagnetic radiation in laser pulses. The controller is configured to obtain an indication of an interworking control scheme for communicating with the laser system. The controller is also configured to receive inputs from an input device. The controller is further configured to communicate with the laser system for control of the laser based on the inputs and according to the interworking control scheme.

Abstract: Embodiments provide systems and methods for probe detection for laser-based surgical systems. In certain embodiments, an optical port includes an optical receptacle configured to receive a detachable optical connector, a first light source configured to emit a first pulsed light beam along a first optical path through the optical receptacle, a first optical sensor located in the first optical path, a second light source configured to emit a second pulsed light beam along a second optical path through the optical receptacle, and a second optical sensor located in the second optical path. The detachable optical connector blocks the first optical path and the second optical path when the detachable optical connector is attached to the optical receptacle, and the first pulsed light beam and the second pulsed light beam include light beam pulses that are emitted at different times.

Abstract: A system including a first laser source configured to generate a first laser beam in a pulsed form, and a second laser source configured to generate a second laser beam. The system further includes an optical fiber configured to: receive the first laser beam, output the first laser beam from a distal end of the optical fiber; receive the second laser beam, output the second laser beam from a distal end of the optical fiber, receive a reflected portion of the second laser beam that is reflected back into the distal end of the optical fiber, and direct the reflected portion of the second laser beam to the optical detector. The optical detector is configured to receive the reflected portion of the second laser beam from the optical fiber and generate an optical detector output based on the reflected portion of the second laser beam.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: Systems and methods are disclosed for dynamically controlling laser pulses being output from a laser system. An example surgical system comprises a laser, an optical switching device, an adjustable input device such as a foot pedal, and a laser pulse controller. An operator actuates the adjustable input device over an operating range to control dynamically the laser pulses being output from the laser system. In one mode, the adjustable input device may dynamically control output laser energy. In another mode, the adjustable input device may dynamically control selection of laser pulses to be output from the system.

Abstract: The present invention relates to pharmaceutical dry powder formulations, comprising (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), preferably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid monohydrate (II) of formula (I-M-II) in combination with a lactose carrier, comprising lactose monohydrate as a mixture of coarse lactose and fine lactose, and to the process of manufacturing such pharmaceutical dry powder formulations and its application for use in the treatment of cardiopulmonary disorders, such as pulmonary arterial

Abstract: A laser system includes a laser. The laser is configured to emit electromagnetic radiation in laser pulses. The laser system includes an optical switching device configured to switch between a first condition that allows laser pulses emitted by the laser to be output from the laser system and a second condition that prevents the laser pulses emitted by the laser from being output from the laser system. The laser system includes a pulse picking controller configured to receive inputs from an input device and communicate optical switching control signals to the optical switching device based on the inputs. The pulse picking controller selects at least one of a synchronous firing timer or an asynchronous firing timer. The asynchronous firing timer causes a beginning of a pulse picking cycle to start based on receipt of an input of the inputs.

Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(triflu-oromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl] [2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of car-diopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hyperten-sion (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pu

Abstract: Methods and systems are provided for forming a molded foam article. An example method may include molding a plurality of separate pieces of closed-cell foam by exposure to a temperature cycle within a sealed mold to soften the plurality of pieces sufficiently for physical bonding; and forming a molded foam article with the pieces bonded together without an adhesive, wherein, during the temperature cycle, the mold is unsealed at least once to release gases and/or pressure. In another example, a method includes exposing a filled, sealed mold filled with a plurality of pieces of foamed material to a heating cycle; at a threshold temperature, unsealing the filled, sealed mold until a pressure reduces to within a threshold of atmospheric pressure; and, following the unsealing, cooling the filled mold prior to removing a molded foam article.

Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmon

Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmo

Abstract: An improved shelving unit for a shipping container is disclosed herein. The improved shelving unit can comprise one or more shelf assemblies and an RFID reader. Each of the one or more shelf assemblies can comprise a bottom platform and a top platform. The RFID reader can be mounted between the bottom platform and the top platform. The top platform can be capable of supporting items.

Abstract: Systems and methods are disclosed for flexibly controlling laser pulses being output from a laser system. An example surgical system comprises a laser, an optical switching device, and a laser pulse controller. Optical switching control signals communicated by the laser pulse controller control the length of a pulse picking cycle and the number of laser pulses in each pulse picking cycle to be output from the laser system. The number of laser pulses in each pulse picking cycle to be output from the laser system may be adjustable in a range that includes more than 50% of the laser pulses in each pulse picking cycle.

Abstract: Systems and methods are disclosed for flexibly controlling laser pulses being output from a laser system. An example surgical system comprises a laser, a laser energy control system configured to regulate the amount of electromagnetic energy of each laser pulse that exits the laser system, and a laser pulse controller. The control signals communicated by the laser pulse controller may include a sub-carrier signal that modulates the amount of electromagnetic energy of the laser pulses that exit the laser system. The control signals may further include a threshold signal and/or a maximum power signal. The sub-carrier signal may oscillate between the threshold power and a maximum power.

Abstract: In some embodiments, a method receives a request for an interface. A configuration for the interface includes a plurality of slots that are associated with a plurality of collection pools, wherein each collection pool is configurable with a ranking strategy. The method determines a collection pool for a slot in the interface where the collection pool is associated with a plurality of collections. A collection is received for the slot. The collection is determined by ranking the plurality of collections using a ranking strategy for the collection pool to generate a ranking of the plurality of collections. The method outputs the collection for the collection pool for display in the slot of the interface.

Abstract: A filter holder for liposome extrusion includes a housing having an inlet configured to receive a material to be extruded and an outlet, and a filter support member disposed within the housing between the inlet and the outlet. The filter support member includes an upstream side having a filter support surface configured to support a membrane filter assembly, a downstream side opposite the upstream side, and a plurality of passages extending through the filter support member from the filter support surface to the downstream side. The filter holder also includes an outlet cavity in fluid communication with the outlet, and the filter holder is configured such that the material to be extruded flows through the membrane filter assembly and into the outlet cavity via the plurality of passages before being discharged through the outlet.

Abstract: Systems and methods are disclosed for dynamically controlling laser pulses being output from a laser system. An example surgical system comprises a laser, an optical switching device, an adjustable input device such as a foot pedal, and a laser pulse controller. An operator actuates the adjustable input device over an operating range to control dynamically the laser pulses being output from the laser system. In one mode, the adjustable input device may dynamically control output laser energy. In another mode, the adjustable input device may dynamically control selection of laser pulses to be output from the system.

Abstract: In some embodiments, a method receives a request for an interface. A configuration for the interface includes a plurality of slots that are associated with a plurality of collection pools, wherein each collection pool is configurable with a ranking strategy. The method determines a collection pool for a slot in the interface where the collection pool is associated with a plurality of collections. A collection is received for the slot. The collection is determined by ranking the plurality of collections using a ranking strategy for the collection pool to generate a ranking of the plurality of collections. The method outputs the collection for the collection pool for display in the slot of the interface.

Abstract: An improved shelving unit for a shipping container is disclosed herein. The improved shelving unit can comprise one or more shelf assemblies and an RFID reader. Each of the one or more shelf assemblies can comprise a bottom platform and a top platform. The RFID reader can be mounted between the bottom platform and the top platform. The top platform can be capable of supporting items.

Abstract: An improved automated inventory system is herein disclosed. The improved automated system (AIS) can comprise an enclosure for storing one or more items, one or more RFID readers, and a control system. Each of the items are tagged with an RFID (radio frequency identification) tag. The enclosure can comprise a plurality of of interior surfaces that defines an interior space within said enclosure. The enclosure can also comprise one or more access points within the interior surfaces that allow access to the items within the enclosure. Each of the RFID readers can be capable of reading the RFID tag. The control system can be in communication with the one or more RFID readers.