Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract: A method of treating an Msk-1 and/or ROCK(1 and 2) mediated disease or condition in a mammal comprising administration of an effective amount of a compounds of the formula (I) and physiologically acceptable salts thereof wherein, R1 is a 5, or 6 membered heterocyclic group selected from group a, b, c or d wherein X1 is a group selected from N or CR7 and X2 is a group selected from O, S or NR8; X3 and X4 which may be the same or different is a group selected from N or CR7; X5 is a group selected from O, S or NR8 and X6 is N or CR7; X7, X8 and X9 may be the same or different and selected from a group N or CR7, pharmaceutical compositions, novel compounds and processes for their preparation.

Abstract: Fused pyradazine derivatives, which are useful as CDK inhibitors are described herein. The described invention also includes methods of making such fused pyradazines derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.

Abstract: Disclosed is a power assist anti-tip wheel system for invalid carriage including at least one connecting support, at least one assist anti-tip wheel, and at least one power driving means. The connecting support is fixedly or detachably connected at one end to a front or a rear side of the invalid carriage. The anti-tip wheel is associated with the connecting support so that it is located in front of or behind the invalid carriage. The power driving means is also associated with the connecting support to drive the anti-tip wheel to rotate when the invalid carriage travels onto a slope or passes a recess or a bulge on a road surface and two drive wheels thereof become suspended and idling. The power driving means can be automatically actuated via a sensing circuit or be manually actuated via a push button.

Abstract: An E-Z Christmas tree waterer (10) to maintain water (12) within a receptacle (14) of a stand (16) having a plurality of holding screws (18), to support a cut trunk (20) of a Christmas tree (22) in an upright position. The waterer waterer (10) comprises a water reservoir (24) having a bottom outlet port (20) and a higher inlet port (28). An elongate conduit (30) has a first end (32) fluidly connected to the bottom outlet port (26) of the water reservoir (24) and a second end (34) extending to the receptacle (14) of the stand (16). A structure (36) is for supporting the water reservoir (24) above the receptacle (14) of the stand (16), so that the water (12) can flow from the water reservoir (24) through the elongate conduit (30) and into the receptacle (14) of the stand (16).