Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: An inverter logic circuit includes a bipolar junction transistor and a zener diode. The zener diode is connected between the base of the bipolar junction transistor and ground (or other reference voltage). The zener diode is reverse biased such that a leakage current through the zener diode allows for sufficient current through the emitter-base terminals of the bipolar junction transistor when a voltage is applied across the emitter and base terminals of the bipolar junction transistor to turn the transistor ON in the absence of an external signal to the base. As such the bipolar junction transistor functions as a normally ON bipolar junction transistor.

Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

Abstract: Systems and methods for voltage regulation of high voltage direct current systems are provided. In certain embodiments, a system includes a generator that generates alternating current (AC) voltage. The system further includes a power converter that converts the AC voltage into regulated direct current (DC) voltage. Also, the system includes a voltage regulator. In additional embodiments, the voltage regulator includes an AC voltage regulator that regulates the AC voltage generated by the generator. Also, the voltage regulator includes a DC voltage regulator that regulates the DC voltage produced by the power converter. Moreover, the voltage regulator includes a regulator selector that selectively activates one of the AC voltage regulator and the DC voltage regulator based on a current from the power converter and at least one of a voltage of the generator and a voltage of the power converter.

Abstract: The present disclosure provides monoclonal antibodies that bind to endothelial monocyte activating polypeptide II and methods of treatment using the same.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: The present technology relates generally to a platform and concrete composite slab system used as a building material. A platform, is formed from joined, substantially coplanar boards with connector plates partially embedded between the boards such that a portion of the connector plates extend above the platform's top surface. A reinforcing material (e.g., wire mesh and/or rebar) can be arranged on the prongs or other portion of the connector plates spaced above the platform and concrete is poured over the reinforcing material and allowed to cure, forming a reinforced concrete layer that encases the connector plates and reinforcing material. The connector plates act as standoffs and help to suspend the reinforcing material in the middle of the concrete layer to increase the strength of the reinforced concrete and to fixedly anchor and bind the concrete layer to the platform, so as to establish a composite action between the platform and the concrete.

Abstract: Systems and methods for voltage regulation of high voltage direct current systems are provided. In certain embodiments, a system includes a generator that generates alternating current (AC) voltage. The system further includes a power converter that converts the AC voltage into regulated direct current (DC) voltage. Also, the system includes a voltage regulator. In additional embodiments, the voltage regulator includes an AC voltage regulator that regulates the AC voltage generated by the generator. Also, the voltage regulator includes a DC voltage regulator that regulates the DC voltage produced by the power converter. Moreover, the voltage regulator includes a regulator selector that selectively activates one of the AC voltage regulator and the DC voltage regulator based on a current from the power converter and at least one of a voltage of the generator and a voltage of the power converter.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: Disclosed are dairy products fortified with dairy minerals and methods of making the dairy products. The fortified dairy products exhibit enhanced fresh dairy flavor notes. In one aspect, the fortified dairy product is a concentrated dairy liquid. In another aspect, the fortified dairy product is a cheese product, such as cream cheese, processed cheese, or cultured cheese.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: The present technology relates generally to a platform and concrete composite slab system used as a building material. A platform, is formed from joined, substantially coplanar boards with connector plates partially embedded between the boards such that a portion of the connector plates extend above the platform's top surface. A reinforcing material (e.g., wire mesh and/or rebar) can be arranged on the prongs or other portion of the connector plates spaced above the platform and concrete is poured over the reinforcing material and allowed to cure, forming a reinforced concrete layer that encases the connector plates and reinforcing material. The connector plates act as standoffs and help to suspend the reinforcing material in the middle of the concrete layer to increase the strength of the reinforced concrete and to fixedly anchor and bind the concrete layer to the platform, so as to establish a composite action between the platform and the concrete.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: A vegetable cane fiber ballistic impact panel and process of manufacturing the ballistic panel. The ballistic panel includes a plurality of vegetable cane fibers (e.g., bamboo fibers) impregnated with a polymer. The vegetable cane fibers are formed into mats of interconnected and entangled fibers and the polymer is formed into polymer films. The polymer films and mats are arranged into a layered assembly having an alternating arrangement and pressed together. The layered assembly is heated to soften the polymer and allow it to flow around the vegetable cane fibers to impregnate the vegetable cane fibers and then cooled. The vegetable cane fibers are generally uniformly distributed through the entire thickness of the panel and vegetable cane fibers originally formed within different mats are entangled with each other.

Abstract: A downhole valve assembly comprises a sleeve concentric with a housing and movable relative to a port through the housing to control flow of fluid through the port. A sensor assembly provides indicates the relative positions of the sleeve and housing, and comprises first and second sensors on e.g. the housing which detect markers on e.g. the sleeve. The sensor outputs are produced by processing (e.g. combining, integrating, summing, subtracting or otherwise processing) the signal components of each of the first and second sensors to correct for misalignment of the sleeve with the housing. The sensor output provides position information for more than one plane, and the output signal therefore allows for correction of errors in the position information arising from misalignment of the sleeve with the housing.

Abstract: The present technology relates generally to a platform and concrete composite slab system used as a building material. A platform, is formed from joined, substantially coplanar boards with connector plates partially embedded between the boards such that a portion of the connector plates extend above the platform's top surface. A reinforcing material (e.g., wire mesh and/or rebar) can be arranged on the prongs or other portion of the connector plates spaced above the platform and concrete is poured over the reinforcing material and allowed to cure, forming a reinforced concrete layer that encases the connector plates and reinforcing material. The connector plates act as standoffs and help to suspend the reinforcing material in the middle of the concrete layer to increase the strength of the reinforced concrete and to fixedly anchor and bind the concrete layer to the platform, so as to establish a composite action between the platform and the concrete.

Abstract: A light-emitting indicator can include a molded, transparent housing formed with a central area shaped as a square that extends in a plane. A plurality of light emitting diodes, optionally formed integrally with the housing, can be positioned along edges of a square that surrounds the central area. The light emitting diodes can emit light to propagate inside the housing toward the central area. A light guide, optionally formed integrally with the housing, can be positioned in a peripheral area shaped to include an area between two concentric squares that surround the central area. The light guide can direct the emitted light out of the plane. Control circuitry can be positioned along the edges of the square that includes the light emitting diodes. The control circuitry can cause the light emitting diodes to blink at a specified frequency, which can draw the attention of a user.

Abstract: Methods and systems for malicious message detection and processing are provided. An example method includes detecting, via an intermediary node, a link included in a message, the link being associated with an unknown resource or a known malicious resource. The intermediary node may have a processor and a memory for storing executable instructions to perform the method. The example method further includes hashing a unique identifier for each recipient of the message; coupling each of the hashed unique identifiers with the link to create an unique updated link for each recipient; and for each recipient, replacing the link in the message with their corresponding unique updated link. The method may include causing forwarding of the updated message with the corresponding unique updated link to each recipient. If the resource is a malicious resource, the unique update link may be to a block webpage associated with a trusted resource.

Abstract: Disclosed are dairy products fortified with dairy minerals and methods of making the dairy products. The fortified dairy products exhibit enhanced fresh dairy flavor notes. In one aspect, the fortified dairy product is a concentrated dairy liquid. In another aspect, the fortified dairy product is a cheese product, such as cream cheese, processed cheese, or cultured cheese.