Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody or fragment thereof, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract: A system for operating a downhole tool includes a tag carrier; a RFID tag coupled with the tag carrier; and a control sub having a bore extending therethrough, the control sub comprising: an antenna located adjacent to the bore; and a stop for catching the tag carrier, wherein: the radio frequency identification tag is coupled with the tag carrier in relation to the stop and the antenna such that the radio frequency identification tag is aligned with the antenna when the tag carrier is caught in the stop, and the stop is operable to allow passage of the tag carrier through the stop after the tag carrier is caught by the stop.

Abstract: A bamboo and/or vegetable cane composite decking and process of manufacturing. The composite decking includes planks formed from a core of bamboo fibers and a polymer layer that covers the top, bottom, and opposing side surfaces of the core. The core includes mats of bamboo fibers stacked together into layers such that the vegetable fibers extend generally parallel to the axial direction of the core. The polymer layer includes a polymer material that protects the vegetable fibers within the core from environmental damage and provides impact resistance to increase the longevity and durability of the plank. The polymer layer can also include bamboo fibers and/or dust that are mixed in with the polymer material to further increase the toughness and durability of the polymer layer.

Abstract: A vegetable cane fiber ballistic impact panel and process of manufacturing the ballistic panel. The ballistic panel includes a plurality of vegetable cane fibers (e.g., bamboo fibers) impregnated with a polymer. The vegetable cane fibers are formed into mats of interconnected and entangled fibers and the polymer is formed into polymer films. The polymer films and mats are arranged into a layered assembly having an alternating arrangement and pressed together. The layered assembly is heated to soften the polymer and allow it to flow around the vegetable cane fibers to impregnate the vegetable cane fibers and then cooled. The vegetable cane fibers are generally uniformly distributed through the entire thickness of the panel and vegetable cane fibers originally formed within different mats are entangled with each other.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: This invention relates to novel substituted benzamide according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A smoke detector having a light source for generating a beam of light is disclosed. The smoke detector is arranged to transmit the beam along an optical axis and includes a sensor for receiving light scattered from the beam off the optical axis by smoke; and a light trap comprising one or more walls that define a volume for receiving light that passes unscattered from the light source past the sensor along the optical axis. The volume includes a first end closest on the optical axis to the light source; and a second end furthest on the optical axis from the light source. The volume is open at said first end but is otherwise closed, and at least one of the walls is sloped from the first end to the second end, such that the light trap progressively narrows from the first end axially towards the second end.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A system for operating a downhole tool includes a tag carrier; a RFID tag coupled with the tag carrier; and a control sub having a bore extending therethrough, the control sub comprising: an antenna located adjacent to the bore; and a stop for catching the tag carrier, wherein: the radio frequency identification tag is coupled with the tag carrier in relation to the stop and the antenna such that the radio frequency identification tag is aligned with the antenna when the tag carrier is caught in the stop, and the stop is operable to allow passage of the tag carrier through the stop after the tag carrier is caught by the stop.

Abstract: This invention relates to novel substituted benzamide according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A natural fiber-based, engineered beam assembly comprising opposing top and bottom surfaces, opposing first and second side surfaces and a longitudinal axis. Loads applied to the beam assembly are normal to the top surface. Substantially parallel layers of flattened bamboo or vegetable cane culms are stacked and laminated together. Each layer is formed by at least one culm, and each culm has fiber bundles extending substantially parallel to the longitudinal axis and are impregnated with a binder. The density of the fiber bundles in the culm decreases across the culm's thickness from the exterior surface to the interior surface. At least a plurality of the culms have a common orientation, wherein the exterior surfaces face toward a same one of the top, bottom, first or second side surfaces.

Abstract: An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody or fragment thereof, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract: A system for operating a downhole tool includes a tag carrier; a RFID tag coupled with the tag carrier; and a control sub having a bore extending therethrough, the control sub comprising: an antenna located adjacent to the bore; and a stop for catching the tag carrier, wherein: the radio frequency identification tag is coupled with the tag carrier in relation to the stop and the antenna such that the radio frequency identification tag is aligned with the antenna when the tag carrier is caught in the stop, and the stop is operable to allow passage of the tag carrier through the stop after the tag carrier is caught by the stop.

Abstract: A method includes receiving, at a control node of a cloud computing network, a first enterprise policy specific to the first enterprise and a second enterprise policy specific to the second enterprise, and managing communications between at least one user device of the first enterprise and the at least one enterprise application hosted on behalf of the first enterprise based on the first enterprise policy. The method also includes managing communications between at least one user device of the second enterprise and the at least one enterprise application hosted on behalf of the second enterprise based on the second enterprise policy.

Abstract: Systems, methods, and apparatus for conditioning bamboo or other types of vegetable cane are provided. In one aspect, the present technology provides a cane processing assembly for use with a substantially flattened sheet of bamboo culm or vegetable cane having a plurality of longitudinally oriented fiber bundles. The assembly comprises first and second conditioning rollers configured to apply pressure to the sheet that breaks at least some natural bonds connecting laterally adjacent fiber bundles in the sheet. The first and second conditioning rollers are adjustable relative to each other so as to vary the pressure applied to the sheet by the first and second conditioning rollers.

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: This invention relates to novel compounds according to Formula (III)(a) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), and to pharmaceutical compositions containing them.

Abstract: A method includes receiving, at a control node of a cloud computing network, a first enterprise policy specific to the first enterprise and a second enterprise policy specific to the second enterprise, and managing communications between at least one user device of the first enterprise and the at least one enterprise application hosted on behalf of the first enterprise based on the first enterprise policy. The method also includes managing communications between at least one user device of the second enterprise and the at least one enterprise application hosted on behalf of the second enterprise based on the second enterprise policy.