Abstract: A system comprising at least one server computer having at least one processor programmed to: receive, over a network, activity data of a first user measured by an activity monitoring device; process the activity data of the first user to update a value of an activity metric for the first user; responsive to updating the value of the activity metric for the first user, identify a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; and, responsive to identifying the change in the inequality relationship, trigger, over the network, a first user device to prompt the first user to generate a message to the second user for display on a second user device.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: A method includes receiving, at a control node of a cloud computing network, a first enterprise policy specific to the first enterprise and a second enterprise policy specific to the second enterprise, and managing communications between at least one user device of the first enterprise and the at least one enterprise application hosted on behalf of the first enterprise based on the first enterprise policy. The method also includes managing communications between at least one user device of the second enterprise and the at least one enterprise application hosted on behalf of the second enterprise based on the second enterprise policy.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: In one embodiment, a method for generating a message to a friend of a user is provided, comprising: processing activity data of a first user measured by an activity monitoring device to update a value of an activity metric for the first user; identifying a change in an inequality relationship between the value of the activity metric for the first user and a value of the activity metric for a second user; in response to identifying the change in the inequality relationship, prompting the first user to generate a message to the second user.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: Malicious message detection and processing systems and methods are provided herein. According to various embodiments, a method includes detecting, via an intermediary node, a link included in a message, the link being associated with an unknown resource, hashing a unique identifier for a recipient of the message, coupling the hashed identifier with the link, creating an updated link and updated message, and forwarding the updated message to the recipient.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A method includes receiving, at a control node of a cloud computing network, a first enterprise policy specific to the first enterprise and a second enterprise policy specific to the second enterprise, and managing communications between at least one user device of the first enterprise and the at least one enterprise application hosted on behalf of the first enterprise based on the first enterprise policy. The method also includes managing communications between at least one user device of the second enterprise and the at least one enterprise application hosted on behalf of the second enterprise based on the second enterprise policy.

Abstract: Malicious message detection and processing systems and methods are provided herein. According to various embodiments, a method includes detecting, via an intermediary node, a link included in a message, the link being associated with an unknown resource, hashing a unique identifier for a recipient of the message, coupling the hashed identifier with the link, creating an updated link and updated message, and forwarding the updated message to the recipient.

Abstract: Malicious message detection and processing systems and methods are provided herein. According to various embodiments, a method includes detecting, via an intermediary node, a link included in a message, the link being associated with an unknown resource, hashing a unique identifier for a recipient of the message, coupling the hashed identifier with the link, creating an updated link and updated message, and forwarding the updated message to the recipient.

Abstract: A backup computer storage system that protects and/or recovers data on a primary computer storage system is disclosed. The backup computer system may be used to backup databases, files, and/or applications. In some embodiments, the backup system may be used to backup an image of the primary computer storage system. In other embodiments, the backup system may be used to backup one or more databases, replicate an image of data that is on the primary computer storage system, restore data from the backup system to the primary computer storage system, restore data to a database while non-affected portions of the database are available and can be used, record all transactions in real time without overwriting any previously stored backup data, and maintain historical and/or chronological information related to backed up data.

Abstract: The present invention provides thienopyridine compounds which are potassium channel inhibitors. In another embodiment, the invention provides pharmaceutical compositions comprising thienopyridines. In another embodiment, the invention provides methods of using thienopyridines in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and inflammatory diseases, including gastric cancer, atrial fibrillation, type-2 diabetes mellitus, rheumatoid arthritis, type-1 diabetes, inflammatory bowel disorder and demyelinating disorders such as multiple sclerosis.

Abstract: A floating marine dock and connection system there for provides plural elongate rectilinear flotation pontoons having a consistent peripheral configuration with a major dimension and a minor dimension and customizable lengths. Connection apparatus interconnected to the flotation pontoons permits the flotation pontoons to be interconnected end-to-end, in parallel, perpendicular to, and spaced apart from one another. Connection straps extend about the outer periphery of the flotation pontoons and interconnect with flanges, plates and accessories desirable for marine docks. The connection straps support a nailer beam to which decking is fastened. Braces extend between spacedly adjacent flotation pontoons to maintain the spatial relationship therebetween and to support service conduits.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: One embodiment provides a cane processing assembly for use with a substantially cylindrical bamboo culm having a longitudinal axis and a plurality of nodes. The assembly comprising a feeder, a perforating station adjacent to the feeder to receive the culm, the perforating station having an annular cutter assembly with cutting blades positioned around an open central area that receives the culm. The cutting blades are radially movable between retracted and extended positions, wherein the cutting blades are positioned to cut into a node around the circumference of the culm. A splitter station receives the culm after the perforating station. The splitter station has a splitting blade configured to cut the culm along its length. A planar station adjacent to the splitter station has a plurality of rollers positioned to engage and flatten the cut culm into a planar configuration.

Abstract: Various exemplary embodiments of a retainer system for a ground engaging tool. In one exemplary embodiment, the retainer system may include a lock configured to receive a portion of a support member to be locked with the ground engaging tool and a retainer bushing including an inner surface configured to rotatably receive the lock. The lock may be rotatable relative to the inner surface of the retainer bushing between an unlocked position and a locked position. The retainer system may also include a plug configured to substantially fill at least a space between the lock and the inner surface of the retainer bushing when the lock is in the locked position.

Abstract: Systems and methods for social marketing engage target markets in a game or competition, while marketing is targeted to the participants of the game or competition. The game or competition is designed to initially attract participants who might be interested in the products or services of a particular business. The game or competition is further designed to retain participants who are more likely to be interested in the products or services such that marketing efforts associated with the game or competition are more likely to reach a desirable target audience. The game or competition is designed to require increased engagement from participants over time, thereby narrowing the participant group to those most interested in the products or services associated with the competition. Marketing efforts can be modified over time during the game or competition to target the narrowed field of participants, namely those most interested in the products or services.