Abstract: Devices, systems, and methods for patient support include arrangement of a patient support top for rotation and a rotation lockout assembly for selectively blocking against rotation of the patient support top.

Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: Devices, systems, and methods for patient support include arrangement of a patient support top for rotation and a rotation lockout assembly for selectively blocking against rotation of the patient support top.

Abstract: A distributed manufacturing platform and related techniques connect designers, manufacturers (e.g., 3D printer owners and other traditional manufacturers), shippers, and other entities and simplifies the process of manufacturing and supplying new and existing products. A distributed ledger or blockchain may be used to record transactions, execute smart contracts, and perform other operations to increase transparency and integrity of supply chain. Blockchain enabled packaging can be used to track movement and conditions of packages from manufacture, through transit, to delivery.

Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.

Abstract: According to aspects of the present disclosure, an implantable pulse generator includes a housing, a header, and a retainer device. The housing includes circuitry and a battery. The header is coupled to the housing and includes a bore configured to receive an end of a lead, and a passage disposed transverse to the bore and extending between an exterior surface of the header and an anchor cavity that extends into the header from the bore. The header supports at least one electrical contact within the bore coupled to the circuitry. The retainer device includes a looped member arranged within the bore, a proximal end extending at least partially into the passage, and anchored at a distal end by the anchor cavity.

Abstract: A drum unloader may include a pump assembly, a motor, a plate, a piston-cylinder assembly, and a sensor. The motor drives the pump assembly. The plate is mounted to the pump assembly and includes an inlet to the pump assembly. The piston-cylinder assembly includes a housing, a piston, and a piston rod. The housing defines a bore. The piston is received within the bore and cooperates with the housing to define a first cavity and a second cavity. The piston rod is attached to and extends from the piston such that the piston rod extends through the first cavity. The piston rod is coupled to the pump assembly, the motor and the plate such that movement of the piston within the bore causes corresponding movement of the pump assembly, the motor and the plate relative to the housing. The sensor measures a pressure within the second cavity.

Abstract: A drum unloader may include a pump assembly, a motor, a plate, a piston-cylinder assembly, and a sensor. The motor drives the pump assembly. The plate is mounted to the pump assembly and includes an inlet to the pump assembly. The piston-cylinder assembly includes a housing, a piston, and a piston rod. The housing defines a bore. The piston is received within the bore and cooperates with the housing to define a first cavity and a second cavity. The piston rod is attached to and extends from the piston such that the piston rod extends through the first cavity. The piston rod is coupled to the pump assembly, the motor and the plate such that movement of the piston within the bore causes corresponding movement of the pump assembly, the motor and the plate relative to the housing. The sensor measures a pressure within the second cavity.

Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.

Abstract: According to aspects of the present disclosure, an implantable pulse generator includes a housing, a header, and a retainer device. The housing includes circuitry and a battery. The header is coupled to the housing and includes a bore configured to receive an end of a lead, and a passage disposed transverse to the bore and extending between an exterior surface of the header and an anchor cavity that extends into the header from the bore. The header supports at least one electrical contact within the bore coupled to the circuitry. The retainer device includes a looped member arranged within the bore, a proximal end extending at least partially into the passage, and anchored at a distal end by the anchor cavity.

Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.

Abstract: According to aspects of the present disclosure, an implantable electrical system may include an implantable pulse generator with a bore sized to receive an electrical lead, with an engagement mechanism that does not require the use of set screws to secure the lead within the bore. The engagement mechanism may include a deformable component that may be moved or deformed to allow entry of the lead into the bore, and then moved or deformed again to engage a surface of the lead to secure the lead within the bore. The engagement mechanism may allow rotation of the lead within the bore while maintaining electrical connections between the generator and the lead. The engagement mechanism may also allow the securing and/or release of the lead relative to the bore without the need to manipulate a set screw or breach a seal of the generator.

Abstract: A particular implantable device includes one or more electrode connectors and multiple circuit elements within a housing. The implantable medical device may also include one or more switches, where each switch of the one or more switches is coupled between one or more of the multiple circuit elements and at least one electrode connector of the one or more electrode connectors.

Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.

Abstract: A method and system for management of thermal energy produced during transcutaneous energy transmission to provide power to energize implanted medical devices. A phase changing material (PCM) acts as a heat sink to absorb thermal energy generated during the energy transfer process. The PCM can be thermally coupled to tissue proximate to an implanted medical device, enabling heat generated within the implantable device to be absorbed. The generation of heat during the energy transfer process is primarily caused by eddy currents induced in the implantable device by the magnetic flux produced by the energy transfer system. The PCM can also be used to absorb heat generated by the device producing the magnetic flux that is used to transcutaneously transfer electrical power to recharge a rechargeable power source or energize the implanted medical device.

Abstract: A case for an implantable medical device includes a metal case portion, having an inside and an outside, configured to attach to at least one other case portion to define a biocompatible case for the implantable medical device. The metal case portion has a plurality of grooves disposed on at least one of the inside and the outside, the grooves being oriented substantially perpendicular to an expected direction of eddy currents produced by an inductive recharging coil in proximity thereto.

Abstract: A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.

Abstract: According to aspects of the present disclosure, an implantable electrical system may include an implantable pulse generator with a bore sized to receive an electrical lead, with an engagement mechanism that does not require the use of set screws to secure the lead within the bore. The engagement mechanism may include a deformable component that may be moved or deformed to allow entry of the lead into the bore, and then moved or deformed again to engage a surface of the lead to secure the lead within the bore. The engagement mechanism may allow rotation of the lead within the bore while maintaining electrical connections between the generator and the lead. The engagement mechanism may also allow the securing and/or release of the lead relative to the bore without the need to manipulate a set screw or breach a seal of the generator.

Abstract: An implantable medical device may include a case which houses components of the implantable medical device. The implantable medical device may include an inductive coil coupled to a rechargeable battery. The inductive coil may be operative to inductively couple to an external coil and to transfer energy from the external coil to the rechargeable battery to recharge the rechargeable battery. The implantable medical device may include a cutout formed in the case of the implantable medical device and filled with a dielectric material. The cutout may be operative to reduce eddy currents in the case during recharge of the rechargeable battery. The implantable medical device may include a slot antenna disposed within the case. The slot antenna may be operative to communicate with an external device through the cutout in the case.

Abstract: A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.