Abstract: An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

Abstract: A laminar flow diffuser with integrated lighting has a frame for supporting an air plenum and a lower housing. The air plenum receives conditioned air from a source of conditioned. The lower housing is attached to the bottom of the plenum. An aperture plate damper installed below the top plenum regulates the flow of air from the plenum through the laminar flow diffuser. A clear or translucent engineered, fire rated polymer perforated diffuser face forms the outlet from the lower housing to the room below. LED strips are positioned around the inside periphery of the lower housing. A light guide is installed adjacent the LED lighting strips to spread the light across the area of the perforated diffuser face.

Abstract: 4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A communication bridge includes interfaces to interact with first and second communication networks and drivers to operate the first and second interfaces. A first internal memory of the communication bridge contains addresses of devices using the first communication network and a second internal memory contains addresses of devices using the second communication network. First and second master application processors in the communication bridge and are in operable communication with respective interfaces and internal memories. The first master application processor associates an address of a message received from a device on the first communication network with the address of a device on the second communication network to enable transmission of the message thereto. The second master application processor associates an address of a message received from a device on the second communication network with the address of a device on the first communication network to enable transmission of the message thereto.

Abstract: 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A pump fluid end includes a body that defines a plunger bore and a working fluid bore that intersects the plunger bore to form a cross bore. A packing bore is defined in the plunger bore and includes a packing sleeve bore, a taper relief bore, and a transition bore. The packing sleeve bore transitions to the taper relief bore at a radial shoulder and the taper relief bore transitions to the plunger bore across the transition bore. The transition bore extends between an external corner contiguous with the plunger bore and an internal corner contiguous with the taper relief bore and at least one of the external and internal corners is rounded and exhibits a radius. The packing bore is treated with a surface pre-stressing treatment.

Abstract: A patch and method for capturing perspiration, the patch comprising an absorbent hydrogel layer and a backing sheet adhering to it, the patch preferably comprising a permeable inner membrane and/or a benefit agent embedded in the hydrogel layer.

Abstract: A method of producing part of an aircraft comprising: providing a frame having a first surface, a second surface, and one or more side edges between the first and second surfaces; mounting the frame to a first tool, the first tool comprising a support surface that contacts the second surface of the frame to opposing movement of the frame; while the frame is mounted to the first tool, machining the first surface to form attachment features; mounting the machined frame to a second tool which contacts with the frame at only the one or more side edges; and, while the frame is mounted to the second tool, attaching, using the attachment features, to the first and second surfaces, aircraft panels to form an outer skin.

Abstract: There is provided systems and methods for pilot alertness and awareness of target aircraft and target obstacle that are flying within a proceeding flight path collision. Transmitted guiding sound signals consisting of three dimensional effects and tonal sounds are generated by a flight unit, and sent to the pilot's headset for the desired purpose of directing the pilot's head position to locate the target aircraft and target obstacle. The flight unit processes time of collision from received target aircraft broadcast, and contain at least GPS data and target obstacle information from stored navigational maps. The flight unit further receives the pilot's head position through means of a head tracker. Furthermore, the flight unit is able to perform the functions of, storing piloted flight information, voice language instruction, flight assisted notification, and communicating with one or multiple mobile devices such for the information to be displayed visually, and is upgradable remotely.

Abstract: An article is worn by a user. A plurality of indicating devices are coupled to the article. A processing unit is communicatively coupled to the plurality of indicating devices. The processing unit selectively actuates at least one indicating device of the plurality of indicating devices based on positional data.

Abstract: There is provided systems and methods for pilot alertness and awareness of target aircraft and target obstacle that are flying within a proceeding flight path collision. Transmitted guiding sound signals consisting of three dimensional effects and tonal sounds are generated by a flight unit, and sent to the pilot's headset for the desired purpose of directing the pilot's head position to locate the target aircraft and target obstacle. The flight unit processes time of collision from received target aircraft broadcast, and contain at least GPS data and target obstacle information from stored navigational maps. The flight unit further receives the pilot's head position through means of a head tracker. Furthermore, the flight unit is able to perform the functions of, storing piloted flight information, voice language instruction, flight assisted notification, and communicating with one or multiple mobile devices such for the information to be displayed visually, and is upgradable remotely.

Abstract: The liquid-assisted micromachining methods include methods of processing a substrate made of a transparent dielectric material. A working surface of the substrate is placed in contact with a liquid-assist medium that comprises fluorine. A focused pulsed laser beam is directed through a first substrate surface and through the opposite working surface to form a focus spot in the liquid-assist medium. The focus spot is then moved over a motion path from its initial position in the liquid-assist medium through the substrate body in the general direction from the working surface to the first surface to create a modification of the transparent dielectric material that defines in the body a core portion. The core portion is removed to form the substrate feature, which can be a through or closed fiber hole that supports one or more optical fibers. Optical components formed using the processed substrate are also disclosed.

Abstract: Pennycress (Thlaspi arvense) seed, seed lots, seed meal, and compositions with reduced glucosinolate content as well as plants that yield such seed, seed lots, seed meal, and compositions are provided. Methods of making and using the pennycress plants and/or seed that provide such seed, seed lots, seed meal, and compositions are also provided.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

Abstract: The present disclosure relates to 4-Azaindazole compounds having the following structure: or a pharmaceutically acceptable salt thereof, for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A laminar flow diffuser with integrated lighting has a frame for supporting an air plenum and a lower housing. The air plenum receives conditioned air from a source of conditioned. The lower housing is attached to the bottom of the plenum. An aperture plate damper installed below the top plenum regulates the flow of air from the plenum through the laminar flow diffuser. A clear or translucent engineered, fire rated polymer perforated diffuser face forms the outlet from the lower housing to the room below. LED strips are positioned around the inside periphery of the lower housing. A light guide is installed adjacent the LED lighting strips to spread the light across the area of the perforated diffuser face.

Abstract: A system is provided with memory and a processor. The memory is configured to store data representative of a multi-valued decision diagram (MDD). The processor is in communication with the memory and is programmed to receive a current selection of one or more of the features, and to determine a feature state for each of the one or more features, based on the current selection and the possible configurations defined by the MDD. The processor is further programmed to calculate an availability bitset indicative of which features as available for further selection, consistent with the valid configurations and without violating existing constraints of the current selection.

Abstract: The present application discloses a compound which is which activates Wnt/?-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.