Abstract: An apparatus for, and method of, simulated virtual component testing, including a processor and a memory, the processor configured to receive a specification datum, receive an application datum, generate emulation parameters as a function of the specification datum, generate a testing framework as a function of the emulation parameters, determine an integration datum as a function of the testing framework and the application datum, output a compatibility datum as a function of the integration datum, and display a user interface.

Abstract: An apparatus for certification of software within virtual integration environments, the apparatus including a processor and a memory communicate connected to the processor, the memory containing instructions configuring the processor to receive a software package for deployment, determine one or more recipients of the software package, select one or more operating environments as a function of the software package and the one or more recipients, wherein each operating environment of the one or more operating environments includes a virtual representation of a system associated with each recipient of the one or more recipients, execute the software package within the one or more operating environments, certify the software package for each operating environment of the one or more operating environments based on the execution of the software package and transmit the certified software package to the one or more recipients.

Abstract: The subject matter disclosed herein relates generally to cancer therapy and to anticancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents that target MC1R and their use in the treatment of cancer. Methods of screening for MC1R targeted agents are also disclosed.

Abstract: A wheel for a bicycle includes a central hub, a rim, and a first spoke array removably attached to the central hub and the rim. The first spoke array is at a first side of the wheel and includes a first central flange and a plurality of first spokes integral with and extending away from the first central flange, such that a first single part is formed. The wheel includes a second spoke array removably attached to the central hub and the radially inner portion of the rim. The second spoke array is at a second side of the wheel. The second side of the wheel is opposite the first side of the wheel. The second spoke array includes a second central flange and a plurality of second spokes integral with and extending away from the second central flange, such that a second single part is formed.

Abstract: An apparatus for virtual integration environments, the apparatus including computing device configured to receive a software package for deployment, determine one or more recipients of the software package, select one or more operating environments as a function of the software package and the one or more recipients, wherein each operating environment of the one or more operating environments is a virtual representation of a system associated with each recipient of the one or more recipients, execute the software package within the one or more operating environments, generate performance data for each operating environment of the one or more operating environments, compare each performance data of the one or more performance data to one or more performance thresholds and graphically display at least the one or more performance data through a graphical user interface.

Abstract: An apparatus for, and method of, simulated virtual component testing, including a processor and a memory, the processor configured to receive a specification datum, receive an application datum, generate emulation parameters as a function of the specification datum, generate a testing framework as a function of the emulation parameters, determine an integration datum as a function of the testing framework and the application datum, output a compatibility datum as a function of the integration datum, and display a user interface.

Abstract: An apparatus for modification of operating environments, includes at least a processor and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the processor to generate update data for one or more operating environments, append a digital signature associated with an update data source to the update data, identify at least one operating environment for receipt of the update data, wherein identification includes determining a compliance of one or more operating environments and identifying the at least one operating environment as a function of the compliance, authenticate the at least one operating environment, wherein authentication includes receiving an update log associated with the at least one operating environment and comparing the update log to a central log and transmit the update data to the at least one operating environment as a function of the authentication to modify the at least one operating environment.

Abstract: A bicycle wheel comprises a rim including a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart from the first sidewall. The first sidewall and the second sidewall extends radially outward from the radially inner portion. A radially outer tire engaging portion is disposed along an outer circumference of the rim. A receptacle is within the radially inner portion. A sensor device comprises a housing disposed within the receptacle such that a portion of the housing forms part of the radially inner portion of the rim and a pressure sensor supported by the housing. An air valve extends through and is supported by the housing. The pressure sensor is fluidly connected to a volume between a first tire retaining portion and a second tire retaining portion of the radially outer tire engaging portion such that the pressure sensor is configured to determine a pressure of a fluid within the volume.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart from the first sidewall. The first sidewall and the second sidewall extend radially outward from the radially inner portion. The rim also includes a radially outer tire engaging portion disposed along an outer circumference of the rim. The radially outer tire engaging portion extends from the first sidewall and the second sidewall, respectively. A maximum width of the rim is in a range between 30 mm and 70 mm, and the rim has an aspect ratio greater than 1.25 but less than 3.0.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, a second sidewall spaced apart from the first sidewall, a radially outer tire engaging portion disposed along an outer circumference of the rim, and an opening. The first sidewall, the second sidewall, the radially outer tire engaging portion, the radially inner portion, or any combination thereof includes a composite laminate. The composite laminate includes one or more compressed layers of a first composite material, which includes a matrix of a polymer-based material and natural fibers for a reinforcing material, and one or more compressed layers of a second composite material that is different than the first composite material. The opening extends through at least one layer of the one or more compressed layers of the second composite material, such that the second composite material surrounds the opening.

Abstract: An apparatus for virtual integration environments, the apparatus including computing device configured to receive a software package for deployment, determine one or more recipients of the software package, select one or more operating environments as a function of the software package and the one or more recipients, wherein each operating environment of the one or more operating environments is a virtual representation of a system associated with each recipient of the one or more recipients, execute the software package within the one or more operating environments, generate performance data for each operating environment of the one or more operating environments, compare each performance data of the one or more performance data to one or more performance thresholds and graphically display at least the one or more performance data through a graphical user interface.

Abstract: An apparatus for modification of operating environments, includes at least a processor and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the processor to generate update data for one or more operating environments, append a digital signature associated with an update data source to the update data, identify at least one operating environment for receipt of the update data, wherein identification includes determining a compliance of one or more operating environments and identifying the at least one operating environment as a function of the compliance, authenticate the at least one operating environment, wherein authentication includes receiving an update log associated with the at least one operating environment and comparing the update log to a central log and transmit the update data to the at least one operating environment as a function of the authentication to modify the at least one operating environment.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart from the first sidewall. The first sidewall and the second sidewall extend radially outward from the radially inner portion. The rim also includes a radially outer tire engaging portion disposed along an outer circumference of the rim. The radially outer tire engaging portion extends from the first sidewall and the second sidewall, respectively. The rim also includes an opening through the radially inner portion at a first circumferential position along the inner circumference. An air valve of the bicycle wheel is positionable through the opening. The rim also includes a receptacle for a sensor device within the radially inner portion at a second circumferential position along the inner circumference. The second circumferential position is different than the first circumferential position.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart form the first sidewall. The first sidewall and the second sidewall extend radially outward from the radially inner portion. The radially inner portion includes a stack of strips of material. The stack of strips includes a plurality of strips and a hole through the plurality of strips. The plurality of strips are nonparallel to each other. The plurality of strips are positioned about the hole through the plurality of strips.

Abstract: Disclosed are TATE derivatives having a linker between the TATE moiety and a macrocyclic radionuclide chelating moiety. Methods of synthesis and use are also disclosed. The compounds preferably exhibit a ratio of kidney: liver uptake by a subject within 24 hours of 5 or less, 3 or less, 1 or less, 0.5 or less, preferably from 2:1 to 1:2.

Abstract: An air deflector that is at least partially disposable within a tubeless tire of a bicycle wheel includes a body. The body includes at least one wall defining an air input end and an air output end of the body. The body is attachable to a valve of the tubeless tire at the air input end, such that when air is introduced into the body via the valve, at least some of the air is deflectable by one or more walls of the at least one wall out of the body at the air output end.

Abstract: The subject matter disclosed herein relates generally to cancer therapy and to anticancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents that target MC1R and their use in the treatment of cancer. Methods of screening for MC1R targeted agents are also disclosed.

Abstract: A rim assembly for a bicycle wheel includes a rim, a first protruding tire retaining feature attached to a first surface of the rim, and a second protruding tire retaining feature attached to a second surface of the rim. The first surface is a surface of a first tire retaining wall of a radially outer tire engaging portion of the rim, and the second surface is a surface of a second tire retaining wall of the radially outer tire engaging portion. The second surface faces the first surface. The first protruding tire retaining feature and the second protruding tire retaining feature are made of a first material, and the first tire retaining wall and the second tire retaining wall are made of a second material. The second material is different than the first material.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart form the first sidewall. The first sidewall and the second sidewall extend radially outward from the radially inner portion. The radially inner portion includes a stack of strips of material. The stack of strips includes a plurality of strips and a hole through the plurality of strips. The plurality of strips are nonparallel to each other. The plurality of strips are positioned about the hole through the plurality of strips.