Abstract: A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch and has a surface area, wherein the outer water-permeable pouch material is formed by a process which includes needle punching.

Abstract: A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch and has a surface area, wherein the outer water-permeable pouch can include a nonwoven web including a heat sealable binder coating having a melting point of about 300° C. or less. Heat sealable binders having a melting point of about 450° C. or greater are also provided herein.

Abstract: Methods and compositions are provided for determining a subtype of lung squamous cell carcinoma (SQ) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for lung squamous cell carcinoma. Also provided herein are methods and compositions for determining the response of an individual with a squamous cell carcinoma subtype to a therapy such as immunotherapy.

Abstract: The disclosure provides a pouched product including a chromogenic material or an electronic component, wherein the chromogenic material and the electronic component are responsive to a stimulus. Such products can be employed to detect various changes associated with the pouched product.

Abstract: Systems, methods, and computer-readable media are disclosed for dynamically determining relative product performance using quantitative values.

Abstract: The disclosure provides oral pouched products including a fleece material with a controlled basis weight. In some embodiments, the oral pouched products may include a material within a porous pouch, wherein the porous pouch includes a fleece material having a basis weight of at least about 35 gsm. In some embodiments, the oral pouched products may include fleece materials have a thickness of at least about 0.2 mm or less than about 0.1 mm. In some embodiments, the pouched products may be configured for rapid or extended release of components contained therein or may be tailored to provide a desired release profile.

Abstract: A pressure relief valve configured to vent a pressurized tank in the event of a fire is provided. The pressure relief valve includes a body, a vent passage, a plug and a latch. The vent passage is disposed through the body. The vent passage can be placed in fluid communication with an internal volume of a tank and with the atmosphere. The plug is moveably mounted in the vent passage. The latch has a blocking member disposed in contact with a control end of the plug in a first configuration and out of contact with the control end in a second configuration. The second configuration allows movement of the plug in the vent passage. One or both of a shape memory alloy wire and a trigger piston is configured to actuate the latch from the first to the second configuration. The shape memory alloy wire is configured to shorten when exposed to a temperature above a threshold temperature. The trigger piston moves, e.g.

Abstract: The disclosure provides pouched products configured for oral use, including a material within a porous pouch, where the porous pouch has four sides of small dimension, where the porous pouch has four sides of large dimension, and/or wherein the porous pouch has a shape other than square or rectangular, e.g., a rounded shape. The disclosure further provides methods of providing a modified mouthfeel with respect to conventional pouched products by providing pouched product in such sizes and/or shapes.

Abstract: A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch and has a surface area, wherein the outer water-permeable pouch can include a nonwoven web including fibers, wherein at least a portion of the fibers are selected from the group consisting of polyester fibers in an amount of 20% or greater based on the total weight of the fibers, tobacco-derived viscose, sisal fibers, corn silk fibers, long wood fibers, MCC fibers, and combinations thereof.

Abstract: The disclosure provides oral products, the oral products including a fleece material that includes fibers and a releasable component. In some embodiments, oral products as described herein may be in the form of a pouchless product including a fleece material having a releasable component associated therewith, or in the form of a pouched product including a fleece material having a releasable component associated therewith in the form of a pouch, containing a substrate material therein.

Abstract: The present disclosure provides methodologies for manufacturing photovoltaic devices. In particular, the disclosure relates to the use of hydrogen during manufacturing of photovoltaic devices for passivating defects in the silicon and addressing light-induced degradation. The methodologies in the present disclosures take advantage of generation and manipulation of hydrogen in the neutral or charged state to optimise defect passivation. Some of the methodologies disclose use thermal treatments, illumination with sub-bandgap photons, electric fields or defects in the silicon to control the state of charge or hydrogen, move hydrogen to different locations in the device or retain hydrogen at specific locations.

Abstract: Methods and compositions are provided for the molecular subtyping of lung cancer samples. Specifically, a method of assessing whether a patient's adenocarcinoma lung cancer subtype is terminal respiratory unit (TRU), proximal inflammatory (PI), or proximal proliferative (PP) is provided herein. The method entails detecting the levels of the classifier biomarkers of Table 1-Table 6 or a subset thereof at the nucleic acid level, in a lung cancer sample obtained from the patient. Based in part on the levels of the classifier biomarkers, the lung cancer sample is classified as a TRU, PI, or PP sample.

Abstract: One example system includes a light source that emits light. The system also includes a waveguide that guides the emitted light from a first side of the waveguide toward a second side of the waveguide opposite the first side. The waveguide has a third side extending between the first side and the second side. The system also includes a mirror that reflects the guided light toward the third side of the waveguide. At least a portion of the reflected light propagates out of the waveguide toward a scene. The system also includes a light detector, and a lens that focuses light from the scene toward the waveguide and the light detector.

Abstract: The present disclosure relates to devices, methods, and computer-readable medium for saving and restoring physical hardware states and virtual machine (VM) states for an application actively being executed on a virtual machine by a user on a computer device. The devices, methods, and computer-readable medium may allow a user to suspend a current state of an application session and save the VM and memory state to persistent storage, and later resume the execution of the saved application session by reading the state back into memory and restoring the VM state.

Abstract: A method of preparing a whitened tobacco material for use in a smokeless tobacco product is provided, including: (i) extracting a tobacco material with an extraction solution to provide a tobacco solids material and a tobacco extract; (ii) cooking the tobacco solids material in an alkaline sulfite cooking liquor including sulfite ions and having a pH of greater than 7 to form a tobacco pulp; (iii) bleaching the tobacco pulp with a bleaching solution to provide a bleached tobacco material; and (iv) drying the bleached tobacco material to provide the whitened tobacco material.

Abstract: A mountable interlock security device for securing first and second sliding articles slidable relative to each other from an open position to a closed position such that in the closed position the sliding articles have overlapping interior edges. The security device comprises a first component mountable to the first sliding article and a second component mountable to the interior edge of the second sliding article. The two components of the security device are mounted to the overlapping end regions of respective sliding articles such that when the sliding articles are in the closed position, the two components of the security device cooperate to limit lateral movement of the sliding articles. In another aspect, a method of retrofitting interior and exterior sliding articles, such as doors or windows, of a building with a security device is provided.

Abstract: The present disclosure provides a method of preparing whitened tobacco composition including chemically pulping a tobacco material to form a tobacco pulp, extracting the tobacco pulp with an extraction solution, treating the tobacco pulp with a solution comprising an oxidizing agent for a time and at a temperature sufficient to lighten the color of the tobacco pulp to give a whitened tobacco pulp, and drying the whitened tobacco pulp to provide the whitened tobacco composition. Alternative bleaching processes and treatment methods effective for preparing whitened tobacco compositions are also provided herein.

Abstract: A method of preparing a whitened tobacco material for use in a smokeless tobacco product, including: (i) extracting a tobacco material with an aqueous solution to provide a tobacco solids material and a tobacco extract; (ii) bleaching the tobacco solids material with a solution comprising a strong base, an oxidizing agent, or a combination thereof to provide a bleached tobacco material; and (iii) drying the bleached tobacco material to provide the whitened tobacco material; wherein the tobacco solids material is not subjected to treatment at an elevated temperature with sulfur-containing reagents, organic solvents, sodium hydroxide, or an acid between the extraction and the bleaching.

Abstract: Methods are provided for determining a subtype of head and neck squamous cell carcinoma (HNSCC) of an individual by detecting the expression level of at least one subtype classifier selected from a group of genes that are relevant for determining HNSCC subtypes. Also provided herein are methods for determining a suitable treatment and predicting the overall survival and the likelihood of metastasis for the HNSCC patients according to their subtypes.

Abstract: This disclosure describes systems, methods, and computer-readable media related to retargeting online advertisement campaign recommendations for advertisements with multiple items or services. Bids may be based on a combined advertisement creative comprising two or more items or services. Dynamically selecting multiple items at bid time using a retargeting model to determine a potential revenue generation amount associated with an event may increase the probability of a conversion event based on the creative that includes the selected items. In some embodiments, a machine-learned retargeting model may be used to select multiple items to be displayed in an advertisement. The retargeting model may be applied to items that were previously viewed by the consumer and may determine a value for each of the items using factors. A bid may be calculated for each of the selected items using the values determined by the retargeting model.