Abstract: The invention provides a method for performing a magnetic resonance measurement of an element in a target region, wherein the element has a magnetic resonance excitation spectrum peak with a linewidth LR, wherein the method comprises a measurement cycle (100) comprising: a magnetization transfer stage (110) comprising providing a plurality of pulses (115) of first radiation to the target region, wherein the plurality of pulses (115) are selected to provide a net pulse having a net pulse angle ?N?1°, and wherein the first radiation comprises a first frequency spectrum peak having a first linewidth LF, wherein the first frequency spectrum peak at least partially overlaps with the magnetic resonance excitation spectrum peak, and wherein LF?5*LR; an excitation stage (130) comprising providing a radio frequency pulse to the target region, wherein the radio frequency pulse excites the element resulting in a transverse magnetization of the element; and a measurement stage (140) comprising detecting a signal from the

Abstract: An ink composition for additive manufacture of silica aerogel objects essentially consists of a gellable silica sol containing an admixture of 30 to 70 vol. % of a mesoporous silica powder in a base solvent. The mesoporous silica powder has a particle size range of 0.001 to 1 mm and a tap density of 30 to 200 kg/m3 and comprises at least 10% by weight of silica aerogel powder. The composition has a yield stress in the range of 30 to 3000 Pa and a viscosity of 5 to 150 Pa·s at a shear rate of 50 s-1. Furthermore, the composition has shear thinning properties defined as a reduction in viscosity by a factor between 10 and 103 for an increase in shear rate by a factor of 104 to 105. A method of additive manufacturing of a three-dimensional silica aerogel object by direct ink writing comprises providing such ink composition, forcing the same through a convergent nozzle, thereby forming a jet of the ink composition which is directed in such manner as to form a three-dimensional object by additive manufacturing.

Abstract: A system for cooling and/or heating one or more articles such as a tumble chiller is disclosed. The system comprises a reservoir 20 configured to contain a cooling and/or heating liquid 22, and a belt conveyor system. The belt conveyor system is configured in a first mode of operation to cause one or more articles to be tumbled within the reservoir 20, and in a second mode of operation to cause the one or more articles to be removed from the reservoir 20.

Abstract: The invention provides a method for performing a magnetic resonance measurement of an element in a target region, wherein the element has a magnetic resonance excitation spectrum peak with a linewidth LR, wherein the method comprises a measurement cycle (100) comprising: a magnetization transfer stage (110) comprising providing a plurality of pulses (115) of first radiation to the target region, wherein the plurality of pulses (115) are selected to provide a net pulse having a net pulse angle ?N?1°, and wherein the first radiation comprises a first frequency spectrum peak having a first linewidth LF, wherein the first frequency spectrum peak at least partially overlaps with the magnetic resonance excitation spectrum peak, and wherein LF>5*LR; an excitation stage (130) comprising providing a radio frequency pulse to the target region, wherein the radio frequency pulse excites the element resulting in a transverse magnetization of the element; and a measurement stage (140) comprising detecting a signal from

Abstract: An ink composition for additive manufacture of silica aerogel objects essentially consists of a gellable silica sol containing an admixture of 30 to 70 vol.% of a mesoporous silica powder in a base solvent. The mesoporous silica powder has a particle size range of 0.001 to 1 mm and a tap density of 30 to 200 kg/m3 and comprises at least 10% by weight of silica aerogel powder. The composition has a yield stress in the range of 30 to 3000 Pa and a viscosity of 5 to 150 Pa·s at a shear rate of 50 s?1. Furthermore, the composition has shear thinning properties defined as a reduction in viscosity by a factor between 10 and 103 for an increase in shear rate by a factor of 104 to 105. A method of additive manufacturing of a three-dimensional silica aerogel object by direct ink writing comprises providing such ink composition, forcing the same through a convergent nozzle, thereby forming a jet of the ink composition which is directed in such manner as to form a three-dimensional object by additive manufacturing.

Abstract: Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma.

Abstract: Embodiments of the instant disclosure generally concern compositions, preparation and methods of use for inhibitory compounds of C-terminal binding proteins (CtBPs), for example, CtBP1 and CtBP2. Certain embodiments concern administering inhibitory compounds of CtBP1 and/or CtBP2 to a subject to treat or reduce the effects of a brain injury or brain trauma in a subject. In other embodiments, agents for inhibiting CtBP1 and/or CtBP2 to treat a subject having a traumatic brain injury (TBI) can include, but are not limited to a peptide capable of inhibiting CtBP expression and/or activity. In other embodiments, agents for inhibiting CtBP1 and/or CtBP2 to treat a subject having a TBI can include, but are not limited to, E1A peptide, a small molecule, an siRNA or a combination thereof. In certain embodiments, CtBP inhibitory agents can be administered alone or as a combination with other CtBP inhibitors.

Abstract: A system for cooling and/or heating one or more articles such as a tumble chiller is disclosed. The system comprises a reservoir 20 configured to contain a cooling and/or heating liquid 22, and a belt conveyor system. The belt conveyor system is configured in a first mode of operation to cause one or more articles to be tumbled within the reservoir 20, and in a second mode of operation to cause the one or more articles to be removed from the reservoir 20.

Abstract: A method and apparatus are disclosed for determining if an item of media is invalid. The method includes providing an ultrasound image of an item of media, determining a plurality of regions of the image that satisfy a pre-determined condition and determining that an item of media is invalid if the location of said regions satisfies a pre-determined condition.

Abstract: In one embodiment, a matching-engine system may receive a set of physician-selection parameters from an administrator. The physician-selection parameters may comprise a range of acceptable performance-scores and experience-scores for physicians. The matching-engine system may receive, from a user, a search query comprising a geographic location of the user, a preferred date and time for an appointment, and a user-specified symptom or a user-specified treatment. A first set of physicians may be determined based on a geographic location of each physician, a performance-score associated with the physician with respect to a base-concept associated with the search query, and an experience-score associated with the physician with respect to the base-concept. A second set of physicians is identified from the first set based on one or more physician preferences, the preferred date and time, and an indication of whether the physician is available at the preferred date and time.

Abstract: In one embodiment, a matching-engine system receives from a user a search query with a location of the user and a user-specified symptom or treatment. The matching-engine system determines a base-concept of a medical diagnosis or medical procedure based on the search query. The matching-engine system may identify a set of physicians to be recommended to the user based on factors relevant to the base-concept such as readmission rate, infection rate, average length-of-stay, relative invasiveness, and healthcare facility ratings. The matching-engine system may send a search-results page to the user listing the recommended physicians.

Abstract: A heat exchange system and apparatus comprising: a compressor to compress a refrigerant, a first condenser heat exchanger to which the compressed refrigerant is supplied and at which heat is transferred from the refrigerant to water in a hot water cylinder; an expansion valve that receives cooled liquid refrigerant from the first heat exchanger; a thermodynamic panel including a second heat exchanger heat that receives cool refrigerant from the expansion valve and is in thermal communication with an environmental heat source.

Abstract: A layering device for producing a layered drink in a drinking container may include a hollow cup with an open top. A circumferential sealing rib may be formed on an exterior surface of a wall of the cup. An opening through the wall may be positioned axially between the rib and the open top of the cup. An outer diameter of the rib may engage with an interior surface of the drinking container.

Abstract: A method and apparatus are disclosed for determining if an item of media is invalid. The method includes providing an ultrasound image of an item of media, determining a plurality of regions of the image that satisfy a pre-determined condition and determining that an item of media is invalid if the location of said regions satisfies a pre-determined condition.

Abstract: A layering device for producing a layered drink in a drinking container may include a hollow cup with an open top. A circumferential sealing rib may be formed on an exterior surface of a wall of the cup. An opening through the wall may be positioned axially between the rib and the open top of the cup. An outer diameter of the rib may engage with an interior surface of the drinking container.

Abstract: A method is provided in various embodiments for determining a profile data set for a subject with skin cancer or a condition related to skin cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables 1-6. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable.

Abstract: The invention provides cytokine modulators and methods for using the same to modulate cytokine production in monocyte lineage-derived cells. In particular, cytokine modulators of the invention selectively bind to a T-cell cytokine-inducing surface molecule (TCISM)-ligand of T lymphocytes or the corresponding TCISM-receptor of monocyte lineage-derived cells, thereby modulating cytokine production in monocyte lineage-derived cells.

Abstract: The invention relates to a method for the MRT representation of a blood vessel (A) and/or of the territory supplied by the blood vessel (A) by labeling the blood, which is guided by this blood vessel (A), by means of continuous arterial spin labeling (CASL), in a specified labeling plane (E). The position of the labeling plan (E) is varied with the provision that a specified location of the blood vessel (A) remains in the labeling plane (E). This enables, for example, a selective labeling of a blood vessel of interest to be saturated by varying the position of the labeling plane.