Abstract: Compositions and formulations comprising diphenhydramine and lactoferrin for preventing or treating infection by a SARS-CoV-related betacoronavirus are described. Methods of using the compositions and formulations are also described. The methods include administering to a patient at risk of being infected by a SARS-CoV-related betacoronavirus or suffering from SARS-CoV-related betacoronavirus-related illness a composition or formulation comprising diphenhydramine and lactoferrin.

Abstract: A method of producing vehicles comprises: in a vehicle production process, manufacturing vehicle components of different types, and assembling the vehicle components to form vehicles; creating a set of vehicle records, each being a record of one of the vehicles entering active service; performing vehicle repairs on a subset of the vehicles after they have entered active service; creating a respective record of each of the vehicle repairs, each of which comprises or indicates a vehicle age or usage value, and records a vehicle component fault identified in the vehicle repair; receiving at a data processing stage the vehicle records and vehicle repair records, wherein a predictive algorithm executed at the data processing stage processes the received records so as to, for each type of vehicle component: 1) identify a respective set of the vehicle repair records relating to that type of vehicle component, and 2) use the respective set of vehicle repair records to predict a respective number of or resource value

Abstract: The invention provides a method for performing a magnetic resonance measurement of an element in a target region, wherein the element has a magnetic resonance excitation spectrum peak with a linewidth LR, wherein the method comprises a measurement cycle (100) comprising: a magnetization transfer stage (110) comprising providing a plurality of pulses (115) of first radiation to the target region, wherein the plurality of pulses (115) are selected to provide a net pulse having a net pulse angle ?N?1°, and wherein the first radiation comprises a first frequency spectrum peak having a first linewidth LF, wherein the first frequency spectrum peak at least partially overlaps with the magnetic resonance excitation spectrum peak, and wherein LF>5*LR; an excitation stage (130) comprising providing a radio frequency pulse to the target region, wherein the radio frequency pulse excites the element resulting in a transverse magnetization of the element; and a measurement stage (140) comprising detecting a signal from

Abstract: An ink composition for additive manufacture of silica aerogel objects essentially consists of a gellable silica sol containing an admixture of 30 to 70 vol.% of a mesoporous silica powder in a base solvent. The mesoporous silica powder has a particle size range of 0.001 to 1 mm and a tap density of 30 to 200 kg/m3 and comprises at least 10% by weight of silica aerogel powder. The composition has a yield stress in the range of 30 to 3000 Pa and a viscosity of 5 to 150 Pa·s at a shear rate of 50 s?1. Furthermore, the composition has shear thinning properties defined as a reduction in viscosity by a factor between 10 and 103 for an increase in shear rate by a factor of 104 to 105. A method of additive manufacturing of a three-dimensional silica aerogel object by direct ink writing comprises providing such ink composition, forcing the same through a convergent nozzle, thereby forming a jet of the ink composition which is directed in such manner as to form a three-dimensional object by additive manufacturing.

Abstract: Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma.

Abstract: Embodiments of the instant disclosure generally concern compositions, preparation and methods of use for inhibitory compounds of C-terminal binding proteins (CtBPs), for example, CtBP1 and CtBP2. Certain embodiments concern administering inhibitory compounds of CtBP1 and/or CtBP2 to a subject to treat or reduce the effects of a brain injury or brain trauma in a subject. In other embodiments, agents for inhibiting CtBP1 and/or CtBP2 to treat a subject having a traumatic brain injury (TBI) can include, but are not limited to a peptide capable of inhibiting CtBP expression and/or activity. In other embodiments, agents for inhibiting CtBP1 and/or CtBP2 to treat a subject having a TBI can include, but are not limited to, E1A peptide, a small molecule, an siRNA or a combination thereof. In certain embodiments, CtBP inhibitory agents can be administered alone or as a combination with other CtBP inhibitors.

Abstract: A system for cooling and/or heating one or more articles such as a tumble chiller is disclosed. The system comprises a reservoir 20 configured to contain a cooling and/or heating liquid 22, and a belt conveyor system. The belt conveyor system is configured in a first mode of operation to cause one or more articles to be tumbled within the reservoir 20, and in a second mode of operation to cause the one or more articles to be removed from the reservoir 20.

Abstract: A method of producing vehicles comprises: in a vehicle production process, manufacturing vehicle components of different types, and assembling the vehicle components to form vehicles; creating a set of vehicle records, each being a record of one of the vehicles entering active service; performing vehicle repairs on a subset of the vehicles after they have entered active service; creating a respective record of each of the vehicle repairs, each of which comprises or indicates a vehicle age or usage value, and records a vehicle component fault identified in the vehicle repair; receiving at a data processing stage the vehicle records and vehicle repair records, wherein a predictive algorithm executed at the data processing stage processes the received records so as to, for each type of vehicle component: 1) identify a respective set of the vehicle repair records relating to that type of vehicle component, and 2) use the respective set of vehicle repair records to predict a respective number of or resource value

Abstract: A method of producing vehicles comprises: in a vehicle production process, manufacturing vehicle components of different types, and assembling the vehicle components to form vehicles; creating a set of vehicle records, each being a record of one of the vehicles entering active service; performing vehicle repairs on a subset of the vehicles after they have entered active service; creating a respective record of each of the vehicle repairs, each of which comprises or indicates a vehicle age or usage value, and records a vehicle component fault identified in the vehicle repair; receiving at a data processing stage the vehicle records and vehicle repair records, wherein a predictive algorithm executed at the data processing stage processes the received records so as to, for each type of vehicle component: 1) identify a respective set of the vehicle repair records relating to that type of vehicle component, and 2) use the respective set of vehicle repair records to predict a respective number of or resource value

Abstract: A computer-implemented method of predicting vehicle faults, the method comprising, at a data processing stage: receiving: i) sets of telematics data each associated with a vehicle identifier, and ii) a vehicle fault dataset, which records historic vehicle fault events, wherein the vehicle fault events are associated in the datasets with cooperating vehicle identifiers; for each of the vehicle identifiers, determining i) a feature object by processing the associated set of telematics data to determine at least one driving style parameter therefrom, the feature object comprising the at least one driving style parameter, and ii) a training label for the feature object based on one or more of the vehicle fault events associated with that vehicle identifier; and using the feature objects and their training labels to train a predictive component, executed at the data processing stage, to learn causal associations between the driving style parameters and the vehicle fault events, such that a feature object comprisin

Abstract: Embodiments of Power Over Ethernet sensors providing processed signals directly to User devices or via a sensor processing system. Other embodiments may be described and claimed.

Abstract: A method of producing vehicles comprises: in a vehicle production process, manufacturing vehicle components of different types, and assembling the vehicle components to form vehicles; creating a set of vehicle records, each being a record of one of the vehicles entering active service; performing vehicle repairs on a subset of the vehicles after they have entered active service; creating a respective record of each of the vehicle repairs, each of which comprises or indicates a vehicle age or usage value, and records a vehicle component fault identified in the vehicle repair; to receiving at a data processing stage the vehicle records and vehicle repair records, wherein a predictive algorithm executed at the data processing stage processes the received records so as to, for each type of vehicle component: 1) identify a respective set of the vehicle repair records relating to that type of vehicle component, and 2) use the respective set of vehicle repair records to predict a respective number of or resource val

Abstract: A computer-implemented method of predicting vehicle failures comprises: receiving, at a processing stage: i) a vehicle diagnostics dataset, which records historic diagnostic warning events and an associated timing for each diagnostic warning event, and ii) a vehicle fault dataset, which records historic vehicle fault events and an associated timing for each vehicle fault event, wherein the diagnostic warning events and vehicle fault events are associated in their respective datasets with cooperating vehicle identifiers; wherein a predictive algorithm executed at the data processing stage determines whether or not each diagnostic warning event of a target type is time-associated with a diagnostic warning event in that its associated timing is within a predetermined time window relative to that of any vehicle fault event associated with a matching vehicle identifier, and computes, based thereon, a significance value for the target type of diagnostic warning event, the significance value denoting the likelihood

Abstract: A method and apparatus are disclosed for determining if an item of media is invalid. The method includes providing an ultrasound image of an item of media, determining a plurality of regions of the image that satisfy a pre-determined condition and determining that an item of media is invalid if the location of said regions satisfies a pre-determined condition.

Abstract: In one embodiment, a matching-engine system may receive a set of physician-selection parameters from an administrator. The physician-selection parameters may comprise a range of acceptable performance-scores and experience-scores for physicians. The matching-engine system may receive, from a user, a search query comprising a geographic location of the user, a preferred date and time for an appointment, and a user-specified symptom or a user-specified treatment. A first set of physicians may be determined based on a geographic location of each physician, a performance-score associated with the physician with respect to a base-concept associated with the search query, and an experience-score associated with the physician with respect to the base-concept. A second set of physicians is identified from the first set based on one or more physician preferences, the preferred date and time, and an indication of whether the physician is available at the preferred date and time.

Abstract: In one embodiment, a matching-engine system receives from a user a search query with a location of the user and a user-specified symptom or treatment. The matching-engine system determines a base-concept of a medical diagnosis or medical procedure based on the search query. The matching-engine system may identify a set of physicians to be recommended to the user based on factors relevant to the base-concept such as readmission rate, infection rate, average length-of-stay, relative invasiveness, and healthcare facility ratings. The matching-engine system may send a search-results page to the user listing the recommended physicians.

Abstract: The present disclosure relates to the field of safety and warning devices, such as a system for zone entry warning. The present disclosure utilizes attaching a stretchable band to the worker enabling the warning of the worker that they are proximate a demarcated zone.

Abstract: A method of creating a simplified computer implementable engine model includes obtaining a complete computer implementable engine model and selecting, from the complete engine model, elements defining the simplified engine model. The method further includes obtaining from a library of rules at least one computer implementable model creation rule corresponding to the selected elements and using that at least one rule to create the simplified computer implementable engine model.

Abstract: A heat exchange system and apparatus comprising: a compressor to compress a refrigerant, a first condenser heat exchanger to which the compressed refrigerant is supplied and at which heat is transferred from the refrigerant to water in a hot water cylinder; an expansion valve that receives cooled liquid refrigerant from the first heat exchanger; a thermodynamic panel including a second heat exchanger heat that receives cool refrigerant from the expansion valve and is in thermal communication with an environmental heat source.