Abstract: Methods of detecting, preventing, treating, controlling or managing progressive neurodegenerative diseases are provided. These methods comprise the administration of antibodies that reduce or eliminate monocytes that abnormally express Astrotactin (ASTNI), or block blood monocytes that abnormally express ASTNI from migrating to the central nervous system. Also provided are pharmaceutical compositions that comprise antibodies that specifically target the extracellular domain (ECD2) of ASTNI for the prevention, treatment, control or management of progressive neurodegenerative diseases.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include receiving, by a cryptographic agility system associated with an application, a request to establish a secure communication session. Embodiments include, prior to establishing the secure communication session, selecting, by the cryptographic agility system, a first cryptographic technique and a second cryptographic technique for the secure communication session. Embodiments include, during the secure communication session, utilizing the first encryption technique for securely communicating a first set of data. Embodiments include determining that a condition has been met for switching from the first encryption technique to the second encryption technique. Embodiments include, based on the determining that the condition has been met, utilizing the second encryption technique for securely communication a second set of data.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include establishing, by a proxy component associated with a cryptographic agility system, a first secure connection with an application. Embodiments include receiving, by the proxy component, via the first secure connection, a communication from the application directed to an endpoint. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information related to the communication. Embodiments include establishing, by the proxy component, a second secure connection with the endpoint based on the cryptographic technique. Embodiments include transmitting, by the proxy component, a secure communication to the endpoint via the second secure connection based on the communication.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include receiving a request from an application for a cryptographic operation, wherein the request is associated with a computing device. Embodiments include determining one or more resource constraints related to the computing device. Embodiments include selecting, based on the one or more resource constraints, a cryptographic technique from a plurality of cryptographic techniques associated with indications of resource requirements. Embodiments include performing the cryptographic operation using the cryptographic technique. Embodiments include providing a response to the application based on performing the cryptographic operation.

Abstract: The disclosure provides an approach for certificate management for cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a cryptographic request related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information associated with the cryptographic request. Embodiments include determining, by the cryptographic agility system, based on the cryptographic request, a certificate for authenticating a key related to the cryptographic technique. Embodiments include providing, by the cryptographic agility system, the certificate to an endpoint related to the cryptographic request for use in authenticating the key.

Abstract: The disclosure provides an approach for auditable cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a request to perform a cryptographic operation related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique for performing the cryptographic operation based on contextual information associated with the request. Embodiments include performing, by the cryptographic agility system, the cryptographic operation using the cryptographic technique. Embodiments include writing, by the cryptographic agility system, data related to selecting the cryptographic technique to a secure digital ledger.

Abstract: System and method for providing trusted execution environments uses a peripheral component interconnect (PCI) device of a computer system to receive and process commands to create and manage a trusted execution environment for a software process running in the computer system. The trusted execution environment created in the PCI device is then used to execute operations for the software process.

Abstract: A system and method may be provided to receive sample RNA reads from patients and generate lists of genes and their associated RNA expression levels in each patient. Some of the RNA reads may be matched to an RNA transcript or gene or gene family in terms of their match likelihood and other RNA reads may be matched to an RNA transcript or gene or gene family through the use of one or more machine learning classifiers. A machine learning classifier may be trained based on the plurality of the lists and a plurality of corresponding patients' clinical status data to identify gene patterns that recur with a high degree of frequency in the plurality of the lists. Those gene patterns can be capable of modifying a disease or treatment response and can be targeted for drug/treatment development.

Abstract: System and method for performing a remote attestation for creation of a trusted execution environment (TEE) using a virtual secure enclave device running in a virtualized environment utilizes a trusted bootloader appliance in a TEE virtual computing instance, which is created in response to a request for a TEE from a software process running in the system. The trusted bootloader appliance manages the provisioning of a TEE in the TEE virtual computing instance for the software process. The remote attestation includes performing a first stage attestation on the trusted bootloader appliance by a hardware platform of the computer system and performing a second stage attestation on the provisioned TEE by the trusted bootloader appliance.

Abstract: Methods of detecting, preventing, treating, controlling or managing progressive neurodegenerative diseases are provided. These methods comprise the administration of antibodies that reduce or eliminate monocytes that abnormally express Astrotactin (ASTN1), or block blood monocytes that abnormally express ASTN1 from migrating to the central nervous system. Also provided are pharmaceutical compositions that comprise antibodies that specifically target the extracellular domain (ECD2) of ASTN1 for the prevention, treatment, control or management of progressive neurodegenerative diseases.

Abstract: A computer-implemented method and system for protecting a host computer in a computer network from security threats uses local security-relevant data for the host computer, as well as global security-relevant data for other components in the computer network downloaded from a security information plane system to the host computer, to determine a security threat to the host computer. When a security threat is determined to be a legitimate threat, a security alert is issued, and then an action is initiated in response to the security alert.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: System and method for performing a remote attestation for creation of a trusted execution environment (TEE) using a virtual secure enclave device running in a virtualized environment utilizes a trusted bootloader appliance in a TEE virtual computing instance, which is created in response to a request for a TEE from a software process running in the system. The trusted bootloader appliance manages the provisioning of a TEE in the TEE virtual computing instance for the software process. The remote attestation includes performing a first stage attestation on the trusted bootloader appliance by a hardware platform of the computer system and performing a second stage attestation on the provisioned TEE by the trusted bootloader appliance.

Abstract: System and method for managing security-relevant information in a computer network uses a security information plane (SIP) manager to which different types of security-relevant data are uploaded from components in the computer network and from which networkwide aggregated security information produced from the security-relevant data is download to a global security controller. The downloaded networkwide aggregated security information is used by the global security controller to control security applications running in the computer network.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: Methods of detecting, preventing, treating, controlling or managing progressive neurodegenerative diseases are provided. These methods comprise the administration of antibodies that reduce or eliminate monocytes that abnormally express Astrotactin (ASTN1), or block blood monocytes that abnormally express ASTN1 from migrating to the central nervous system. Also provided are pharmaceutical compositions that comprise antibodies that specifically target the extracellular domain (ECD2) of ASTN1 for the prevention, treatment, control or management of progressive neurodegenerative diseases.

Abstract: A system and method may be provided to receive sample RNA reads from patients and generate lists of genes and their associated RNA expression levels in each patient. Some of the RNA reads may be matched to an RNA transcript or gene or gene family in terms of their match likelihood and other RNA reads may be matched to an RNA transcript or gene or gene family through the use of one or more machine learning classifiers. A machine learning classifier may be trained based on the plurality of the lists and a plurality of corresponding patients' clinical status data to identify gene patterns that recur with a high degree of frequency in the plurality of the lists. Those gene patterns can be capable of modifying a disease or treatment response and can be targeted for drug/treatment development.

Abstract: System and method for creating and managing trusted execution environments (TEEs) using different underlying hardware TEE mechanisms use a virtual secure enclave device which runs in a virtualized environment in a computer system. The device enables an enclave command transmitted to the virtual secure enclave device to be retrieved and parsed to extract an enclave operation to be executed. A TEE backend module is used to interact with a particular hardware TEE mechanism among those available in the computer system. The module ensures the enclave operation for the software process is executed by the particular hardware TEE mechanism, or the TEE scheme based on a particular hardware TEE mechanism.

Abstract: System and method for providing trusted execution environments uses a peripheral component interconnect (PCI) device of a computer system to receive and process commands to create and manage a trusted execution environment for a software process running in the computer system. The trusted execution environment created in the PCI device is then used to execute operations for the software process.