Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: A tool 10 for driving a stake 14 into the ground, the tool 10 comprising a sleeve 12 for receiving therein the stake 14 and defining a first aperture 30 at an end into which the stake 14 can be inserted, and a plunger 34 slidingly receivable within the sleeve 12 and extendable through a second aperture 51 of the sleeve 12, the plunger 34 comprising a first end 38 for receiving a strike force and a second end 36 for contacting the stake 14, wherein the plunger 34 is arranged to transfer the strike force received at the first end 38 to the stake 14 via the second end 36.

Abstract: The present disclosure provides metalloporphyrin and metallochlorin compounds (e.g., compounds of Formula (II) and (III)), which are useful in the preparation of optical devices (e.g., contact lenses, intraocular lenses, implantable contact lenses) that protect retinal pigment epithelium by the selective blocking of blue light. Also provided are precursor porphyrin and chlorin compounds (e.g., compounds of Formula (I)), and compositions and optical devices incorporating the compounds of the disclosure. Also provided are methods of selecting appropriate metalloporphyrin and metallochlorin compounds for incorporation into optical devices wherein the devices mitigate damage to retinal epithelial cells while balancing changes to luminous transmission, discomfort glare, color distortion, and disruption of circadian rhythms.

Abstract: An appliance is provided that is able to vacuum and heat seal plastic bag members containing liquids such as sauces and soups. The appliance may take on a uniquely shaped profile to allow the liquid to sit upright within a bag during the vacuuming process. The appliance also preferably includes a pressure sensor to constantly monitor pressure inside of the bag during the vacuum and sealing process. This may help to prevent liquid from being sucked up and into the appliance.

Abstract: In an example, a method comprises, by logic circuitry associated with a replaceable print apparatus component, responding to a first validation request sent via an I2C bus to a first address associated with the logic circuitry with a first validation response; and responding to a second validation request sent via the I2C bus to a second address associated with the logic circuitry with a second validation response.

Abstract: An information technology (IT) network includes configuration items (CIs) that may constantly change, where the CIs describe hardware components or software components that are configured to operate on the IT network. Machine learning techniques can be employed determine whether a CI has been changed (e.g., added, updated, or removed) in the IT network. For example, a software code or a log message associated with a CI can be analyzed to determine whether the CI is a newly added or updated within the IT network.

Abstract: A connection point assembly for a patient lifter spreader bar has a hook member defining a throat having a mouth, the mouth being formed between a distal end of the hook member and an adjacent base portion and a latch assembly operably coupled to the hook member at the mouth and comprising a latch configurable between an open position wherein the latch does not obstruct the mouth and a closed position wherein the latch obstructs the mouth. The connection point assembly comprises a visual indicator indicative of the open position and the closed position.

Abstract: Solution production devices, systems, and methods. The system includes a base portion configured to receive a vessel containing a liquid. Upon the base portion receiving the vessel, liquid is transferred from the vessel and into the base portion where it undergoes an electrochemical reaction to produce a cleaning solution. The cleaning solution is then circulated back into the vessel.

Abstract: A logic circuitry package for a replaceable print apparatus component comprises an interface to communicate with a print apparatus logic circuit, and at least one logic circuit. The logic circuit may be configured to identify, from a command stream received from the print apparatus, parameters including a class parameter, and/or identify, from the command stream, a read request, and output, via the interface, a count value in response to a read request, the count value based on identified received parameters.

Abstract: A logic circuitry package for a replaceable print apparatus component includes an interface and at least one logic circuit. The at least one logic circuit is configured to respond to communications sent to a first address via the interface and respond to communications sent to a second address via the interface. The at least one logic circuit is configured to in response to a hibernate command sent to the first address, respond to communications sent to the second address.

Abstract: In an example, a method includes, by logic circuitry associated with a replaceable print apparatus component installed in a print apparatus, responding to a sensor data request received from the print apparatus by returning a first response; receiving a calibration parameter from the print apparatus; and returning a second response which is different from the first response.

Abstract: An information technology (IT) network includes configuration items (CIs) that may constantly change, where the CIs describe hardware components or software components that are configured to operate on the IT network. A system comprising a server can determine a change associated with a CI, send, to a configuration management database (CMDB), a message that updates the CMDB based on the determined change associated with the CI, determine, for the CI, a monitor configuration that describes one or more variables and corresponding one or more parameters with which the CI is to be monitored, and send the CI with the monitor configuration to a plurality of monitoring software tools operating on a plurality of servers, where each monitoring software tool is configured to monitor the CI based on the monitor configuration.

Abstract: Systems and methods of matching identifiers between multiple datasets are described herein. A system can transmit a first identifier vector to a third party server. The first identifier vector can include a first identifier, first parameters, and second parameters. The system can receive, from the third party server, the first identifier vector encrypted based on a third-party encryption. The system can receive, from the third party server, a second identifier vector encrypted based on the third-party encryption associated with the third party server. The second identifier vector can include a second identifier, third parameters, and fourth parameters. The system can determine a correlation count between the first identifier vector and the second identifier vector. The system can determine that the first identifier corresponds to the second identifier based on the correlation count. The system can generate one identifier key for both the first identifier and the second identifier.

Abstract: Provided herein are dendrimer-targeting agent conjugates comprising a dendrimer, the dendrimer comprising a core unit and lysine or lysine analogue building units, a HER2 targeting agent which is a peptidic moiety having a molecular weight of up to about 80 kDa and comprising an antigen-binding site, which is covalently linked by a spacer group, and a therapeutic agent which is covalently linked to a surface building unit of the dendrimer. Also provided herein are compositions comprising the conjugates, and therapeutic methods using the conjugates, particularly for treating cancer.

Abstract: Disclosed are methods of treating cancer in a subject, comprising subcutaneously administering to the subject an effective amount of a dendrimer of formula (I): and pharmaceutically acceptable salts thereof.

Abstract: A logic circuitry package for a replaceable print apparatus component comprises an interface to communicate with a print apparatus logic circuit, and at least one logic circuit. The logic circuit may be configured to identify, from a command stream received from the print apparatus, parameters including a class parameter, and/or identify, from the command stream, a read request, and output, via the interface, a count value in response to a read request, the count value based on identified received parameters.

Abstract: A logic circuitry package for a replaceable print apparatus component includes an interface to communicate with a print apparatus logic circuit, and a logic circuit having a communication address to communicate with the print apparatus logic circuit. The logic circuit is configured to detect, via the interface, communications that include an other communication address. The logic circuit is configured to respond, via the interface, to a command series directed to the logic circuit that include the communication address of the logic circuit, based on the detected communications.

Abstract: A wafer shape metrology system includes a wafer shape metrology sub-system configured to perform one or more stress-free shape measurements on a first wafer, a second wafer, and a post-bonding pair of the first and second wafers. The wafer shape metrology system includes a controller communicatively coupled to the wafer shape metrology sub-system. The controller is configured to receive stress-free shape measurements from the wafer shape sub-system; predict overlay between one or more features on the first wafer and the second wafer based on the stress-free shape measurements of the first wafer, the second wafer, and the post-bonding pair of the first wafer and the second wafer; and provide a feedback adjustment to one or more process tools based on the predicted overlay. Additionally, feedforward and feedback adjustments may be provided to one or more process tools.

Abstract: Systems and methods of matching identifiers between multiple datasets are described herein. A system can transmit a first identifier vector to a third party server. The first identifier vector can include a first identifier, first parameters, and second parameters. The system can receive, from the third party server, the first identifier vector encrypted based on a third-party encryption. The system can receive, from the third party server, a second identifier vector encrypted based on the third-party encryption associated with the third party server. The second identifier vector can include a second identifier, third parameters, and fourth parameters. The system can determine a correlation count between the first identifier vector and the second identifier vector. The system can determine that the first identifier corresponds to the second identifier based on the correlation count. The system can generate one identifier key for both the first identifier and the second identifier.