Abstract: An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.

Abstract: A lightguide having opposing first and second major surfaces where the first major surface includes a plurality of extended features and a plurality of discrete features is described. The lightguide has a viewable area having a length at least 100 times a thickness of the lightguide. The extended features extend in a first in-plane direction across at least 90 percent of the length L of the viewable area. The discrete features are spaced apart along the length and width of the viewable area. The discrete features may be disposed in spaces between the extended features. The discrete features may have faces extending between and connecting adjacent extended features.

Abstract: Embodiments of a community-integrated smart playground of this disclosure and a method of its use include tracking geo-specific play data, populating a queue of digital notices, displaying one or more of the digital notices on a mobile device as a user plays on the playground and progresses through a virtual game dependent upon the playground activity, and producing revenue for the playground through the display or use of the digital notices. The playground includes at least one physical play structure containing a computer-readable identification tag, the at least one physical play structure representing a physical play activity. The virtual game may be non-analogous to the physical play but game progress is determined by the physical play. The system and method of its use may be executed by at least one mobile device having at least one microprocessor in network communication with the computer-readable identification tag and including associated software.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: A method of treating osteoarthritis by modifying the shape change of bone(s) underlying articular cartilage, comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint is disclosed.

Abstract: A cloud based pulse oximetry system and method is provided that incorporates both a software and hardware component. The hardware component includes a limited use pulse oximetry probe having an energy source and data transmitting capabilities. The probe houses a light source and a light detector that compare and calculate the differences in the oxygen-rich versus oxygen-poor hemoglobin in the body part to which, it is attached. Data from the probe is collected, analyzed, and communicated using a cloud based computing system. The system may be used for collecting and analyzing pulse oximetry data for any medical need such as diagnosis of obstructive sleep apnea.

Abstract: An optical film includes a microstructured surface having a plurality of irregularly arranged planar portions forming greater than about 10% of the microstructured surface. The microstructured surface may be configured such that, when the microstructured surface is placed on an emission surface of a lightguide with a first luminous distribution of light exiting the lightguide from the emission surface in a first plane perpendicular to the emission surface, the light emitted by the lightguide is transmitted by the microstructured surface at a second luminous distribution of the transmitted light in the first plane. The first luminous distribution includes a first peak making a first angle greater than about 60 degrees with a normal to the microstructured surface. The second luminous distribution includes a second peak making a second angle in a range from about 5 degrees to about 35 degrees with the normal to the microstructured surface.

Abstract: Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.

Abstract: A lightguide having opposing first and second major surfaces where the first major surface includes a plurality of extended features and a plurality of discrete features is described. The lightguide has a viewable area having a length at least 100 times a thickness of the lightguide. The extended features extend in a first in-plane direction across at least 90 percent of the length L of the viewable area. The discrete features are spaced apart along the length and width of the viewable area. The discrete features may be disposed in spaces between the extended features. The discrete features may have faces extending between and connecting adjacent extended features.

Abstract: Recycling backlights are described. More specifically, recycling backlights including structured reflectors are described. The structured reflector redirects light at least for angles emitted from a lightguide and retroreflects other light, the retroreflected light having incidence angles not emitted by the lightguide.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: Knee pain evaluation and management is carried out via intra-articular injections into a patient suffering from knee pain with the injection being comprised of water and a particularly defined peptide. After injection, knee pain is evaluated using a pain subscale such as WOMAC or KOOS.

Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.

Abstract: An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.

Abstract: Recycling backlights are described. More specifically, recycling backlights including structured reflectors are described. The structured reflector redirects light at least for angles emitted from a lightguide and retroreflects other light, the retroreflected light having incidence angles not emitted by the lightguide.

Abstract: A method and system for assigning data packet transmission in a wireless communications network is provided. The method comprises receiving first and second user data packets having respective first and second packet sizes, one of the packet sizes being larger than the other, determining an uplink/downlink ratio based on network statistics, and assigning the first and second data packets to respective first and second signal carrier spectrums each having a different time interval between uplink transmissions with the network. A system is also provided comprising a network controller configured to receive data packets and assign individual data packets to one of a first and a second signal carrier spectrum based on the size of the data packets, the first and the second signal carrier spectrums having the same uplink/downlink ratio and different uplink intervals.

Abstract: The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: Systems and methods for generating sound profiles of artificial commands detected by multiple voice activated electronic devices is described herein. In some embodiments, numerous voice activated electronic devices may send audio data representing a phrase to a backend system at a substantially same time. Text data representing the phrase, and counts for instances of that text data, may be generated. If the number of counts exceeds a predefined threshold, the backend system may cause any remaining response generation functionality that particular command that is in excess of the predefined threshold to be stopped, and those devices returned to a sleep state. In some embodiments, a sound profile unique to the phrase that caused the excess of the predefined threshold may be generated such that future instances of the same phrase may be recognized prior to text data being generated, conserving the backend system's resources.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.