Abstract: A lightguide having opposing first and second major surfaces where the first major surface includes a plurality of extended features and a plurality of discrete features is described. The lightguide has a viewable area having a length at least 100 times a thickness of the lightguide. The extended features extend in a first in-plane direction across at least 90 percent of the length L of the viewable area. The discrete features are spaced apart along the length and width of the viewable area. The discrete features may be disposed in spaces between the extended features. The discrete features may have faces extending between and connecting adjacent extended features.

Abstract: Recycling backlights are described. More specifically, recycling backlights including structured reflectors are described. The structured reflector redirects light at least for angles emitted from a lightguide and retroreflects other light, the retroreflected light having incidence angles not emitted by the lightguide.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: Knee pain evaluation and management is carried out via intra-articular injections into a patient suffering from knee pain with the injection being comprised of water and a particularly defined peptide. After injection, knee pain is evaluated using a pain subscale such as WOMAC or KOOS.

Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.

Abstract: An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.

Abstract: Recycling backlights are described. More specifically, recycling backlights including structured reflectors are described. The structured reflector redirects light at least for angles emitted from a lightguide and retroreflects other light, the retroreflected light having incidence angles not emitted by the lightguide.

Abstract: A method and system for assigning data packet transmission in a wireless communications network is provided. The method comprises receiving first and second user data packets having respective first and second packet sizes, one of the packet sizes being larger than the other, determining an uplink/downlink ratio based on network statistics, and assigning the first and second data packets to respective first and second signal carrier spectrums each having a different time interval between uplink transmissions with the network. A system is also provided comprising a network controller configured to receive data packets and assign individual data packets to one of a first and a second signal carrier spectrum based on the size of the data packets, the first and the second signal carrier spectrums having the same uplink/downlink ratio and different uplink intervals.

Abstract: The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: Systems and methods for generating sound profiles of artificial commands detected by multiple voice activated electronic devices is described herein. In some embodiments, numerous voice activated electronic devices may send audio data representing a phrase to a backend system at a substantially same time. Text data representing the phrase, and counts for instances of that text data, may be generated. If the number of counts exceeds a predefined threshold, the backend system may cause any remaining response generation functionality that particular command that is in excess of the predefined threshold to be stopped, and those devices returned to a sleep state. In some embodiments, a sound profile unique to the phrase that caused the excess of the predefined threshold may be generated such that future instances of the same phrase may be recognized prior to text data being generated, conserving the backend system's resources.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: The present invention is directed to Benzomorphan Analog compounds of the Formula (I), Formula (IA), Formula (IB), Formula (IC), or Formula (ID) as shown below, wherein R1, R2a, R2b, R3, R4, Z, and G are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

Abstract: User-specific language models (LMs) that include internal word indexes to a word table specific to the user-specific LM rather than a word table specific to a system-wide LM. When the system-wide LM is updated, the word table of the user-specific LM may be updated to translate the user-specific indices to system-wide indices. This prevents having to update the internal indices of the user-specific LM every time the system-wide LM is updated.

Abstract: A method and system for assigning data packet transmission in a wireless communications network is provided. The method comprises receiving first and second user data packets having respective first and second packet sizes, one of the packet sizes being larger than the other, determining an uplink/downlink ratio based on network statistics, and assigning the first and second data packets to respective first and second signal carrier spectrums each having a different time interval between uplink transmissions with the network. A system is also provided comprising a network controller configured to receive data packets and assign individual data packets to one of a first and a second signal carrier spectrum based on the size of the data packets, the first and the second signal carrier spectrums having the same uplink/downlink ratio and different uplink intervals.

Abstract: The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.

Abstract: Systems and methods for detecting similar audio being received by separate voice activated electronic devices, and ignoring those commands, is described herein. In some embodiments, a voice activated electronic device may be activated by a wakeword that is output by the additional electronic device, such as a television or radio, may capture audio of sound subsequently following the wakeword, and may send audio data representing the sound to a backend system. Upon receipt, the backend system may, in parallel to performing automated speech recognition processing to the audio data, generate a sound profile of the audio data, and may compare that sound profile to sound profiles of recently received audio data and/or flagged sound profiles. If the generated sound profile is determined to match another sound profiles, then the automated speech recognition processing may be stopped, and the voice activated electronic device may be instructed to return to a keyword spotting mode.

Abstract: A method is disclosed in which control processes are used to maintain consistency across a research or diagnostic series of steps. Some embodiments of the processes include the use of fresh or lyophilized cell lines, beads, surface or other markers. The use of quality control processes is intended to monitor data from the underlying methods in order to detect unacceptable variations and to allow for exclusion or normalization. Overlapping control processes allows for tighter control and for redundancy in the monitoring.

Abstract: The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

Abstract: The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.