Abstract: Marine animal oil free of undesirable odor or taste is produced by treating a freshly killed marine animal with a peroxidase-inhibiting antioxidant, disaggregating the marine animal, separating the oil phase, mixing with a dilute aqueous acidic solution, removing the oil phase and adding antioxidant. Marine animal oil which has already turned rancid may be restored to a non-rancid state by mixing with a reducing antioxidant such as a thiodipropionate, separating out the fatty acids which have reacted with the antioxidant, preferably by column chromatography, and adding another antioxidant to prevent further peroxidation.

Abstract: A process for obtaining fish meal which is essentially free of oil, as well as recovering valuable free polyunsaturated fatty acids, comprising hydrolyzing membrane phospholipids in comminuted fish with aqueous alkali solution, at a temperature which is not substantially above ambient, adding a strong acid to release free polyunsaturated fatty acids, recovering the free fatty acids from the aqueous phase by mechanical separation, and drying the aqueous phase.

Abstract: A method is provided for preparing unsaturated fatty acids having triple bonds by reducing the double bonds of unsaturated fatty acids. The unsaturated, double-bonded fatty acid is reacted with a halogen gas to form a halogenated fatty acid, and this brominated fattay acid is mixed with a strong base and 1,3-dicyclohexylcarbodiimide to form a salt of a triple bonded fatty acid. This salt is then reacted with an acid to form the desired triple bonded fatty acid.

Abstract: A suspended substrate rat-race coupler utilizes an elliptic configuration of the usual circular rat-race coupler on a circuit card positioned within below cut-off suspended substrate housing channels. The channels within the suspended substrate housing are positioned to receive the arms of the elliptical rat-race coupler. The longitudinal axis of two of the suspended substrate channels are offset with respect to each other to accommodate the rat-race arms and are positioned either on the same side of a primary suspended substrate channel or on opposite sides of the primary suspended substrate channel. Connections to the four ports of the rat-race can thus be made without disrupting the TEM propagation mode within the suspended substrate device.

Abstract: A planar millimeter wave circuit for splitting a very wide input frequency and into three or more lesser bands utilizes bandpass filters exclusively. A triplexer is made by connecting the bandpass filters with coupled line equivalents fed by a conductor with a characteristic impedance the same as the input conductor to the filters and of an appropriate length so as to make the diplexer appear open or nearly open circuited over the adjacent frequency range of a third bandpass filter used in the triplexer or, alternatively, over the adjacent frequency range of a second diplexer connected so as to form a quadruplexer.

Abstract: Saturated aliphatic straight chain dicarboxylic acids having a total number of carbon atoms which are divisible by four, are selectively toxic to certain tumor cells while non-toxic to normal cells of the same origin. Octacosanedioic acid is particularly preferred as it is a component of normal blood serum. Compositions containing these compounds may be used in the treatment of certain malignancies.

Abstract: Free fatty acids form fish oil, DHA and EPA, are useful in treating rheumatoid arthritis. The free fatty acids were an order of magnitude more effective in treating arthritis than unhydrolyzed fatty acids derived from fish oil.

Abstract: To extract and purify of polyunsaturated fatty acids, particularly EPA and DHA, without cis-trans conversion, from naturally occurring oils, such as marine animal oil and various vegetable oils a mixture of free fatty acids is first extracted from the oil. The resulting mixture of pure fatty acids is then subjected to separation by means of urea complexing to remove saturated fatty acids and most mono-unsaturated fatty acids. Remaining solvent and urea are then removed from the filtrate which is then subjected to low temperature fractional crystallization in the presence of an organic solvent such as acetone. Substantially pure polyunsaturated fatty acids, especially EPA and DHA, can be separately precipitated by reducing the temperature of the filtrate in two steps. Alternatively, the volume of the filtrate is reduced in two steps and cooled to form precipitates, which are removed. The final product is a mixture of substantially pure DHA and EPA.

Abstract: The effectiveness of interferon for treatment against cancer may be increased by first administering an agent for inhibiting tyrosinase. In this manner the tyrosinase which is known to be produced by malignancies, and which may cause inactivation of the interferon, will be substantially inactivated prior to the interferon administration.

Abstract: Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or is water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention.

Abstract: A method for the treatment of asthma, nasal congestion and anaphylactic shock involves nasal or oral administration of 8,11,14,17-eicosatetraenoic acid. Pharmaceutical compositions for this purpose are prepared containing 8,11,14,17-eicosatetraenoic acid and pharmaceutically acceptable vehicles, as well as, preferably, a suitable anti-oxidant.

Abstract: Treatment of prophylaxis of thrombo-embolic conditions is obtained through the simultaneous administration of eicosapentaenoic acid and/or docosahexaenoic acid together with one or more of linoleic acid, .gamma.-linolenic acid and dihomo-.gamma.-linolenic acid, either in the form of a pharmaceutical dosage or in the form of a food product such as margarine or cooking oil.

Abstract: Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. When nitrile-containing aglycones are used sodium thiosulfate is also administered to avoid cyanide poisoning. A loading dose of glucuronide greater than 2 mMoles per kilogram body weight is first administered with additional administration of one third the initial dose each hour as long as .beta.-glucuronidase activity remains at the tumor site. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention.

Abstract: A millimeter wave suspended substrate multiplexer is disclosed which is comprised of a plurality of hybrid-filter-hybrid channel dropping sections. The components of the multiplexer are enclosed in a metallic housing forming a cavity surrounding the multiplexer components. Each of the hybrid-filter-hybrid sections is comprised of first and second 90.degree. hybrid couplers which are connected by a pair of identical bandpass filters. Spurious waveguide energy propagation modes which would otherwise be generated in the cavity surrounding the 90.degree. suspended hybrid couplers are eliminated by the use of a plurality of mode suppression pins extending between the top and bottom portions of the metallic housing and passing through the branch lines of the couplers.

Abstract: Mandelonitrile-.beta.-D-glucuronic acid is produced by condensing a mandelic amide with a tri-O-acetyl methyl ester of glucuronic acid and then reacting the product with acetic anhydride to produce the tri-O-acetyl methyl ester of mandelonitrile-.beta.-D-glucuronic acid. The protecting acetyl groups may be removed and the barium salt formed by reacting with barium hydroxide, which salt, when treated with sulfuric acid, will yield the mandelonitrile-.beta.-D-glucuronic acid. This compound, as well as methacrylonitrile .beta.-D-glucuronic acid may be used in the treatment of bacterial infections having .beta.-glucuronidase activity.

Abstract: A microstrip integrated circuit reflection amplifier utilizing packaged diodes and permitting some gain and bandwidth adjustment. A 3 db quadrature coupler has two of its ports connected to substantially identical reflection amplifiers. The reflection diodes are adjustably mounted in brackets perpendicular to the dielectric substrate of the microstrip network and may be moved in and out along the microstrip circuit to provide for some gain correction and bandwidth adjustment.

Abstract: A method of diagnosing the presence of tumors having .beta.-glucuronidase activity comprises administering a glucuronide which differs in color or color intensity from the aglycone thereof to a patient. The preferred glucuronide is phenolphthalein glucuronide. The urine is then collecting for a twenty four hour period and the amount of phenolphthalein glucuronides present in the urine is determined. If substantially all of the phenolphthalein glucuronide is expelled then it is apparent that the body has no tumors or bacterial infections exhibiting .beta.-glucuronidase activity. If however substantial amounts of phenolphthalein is retained, then this is an indication of the presence of tumors having .beta.-glucuronidase activity or a bacterial infection having .beta.-glucuronidase activity.

Abstract: Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. When nitrile-containing aglycones are used sodium thiosulfate is also administered to avoid cyanide poisoning. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or are water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention.

Abstract: Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or is water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention.