Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: A computer-implemented method for dynamic resource management can include evaluating, by at least one processor, whether a priority of one or more processes associated with a request for one or more shared resources meets a threshold condition. The method can additionally include determining, by the at least one processor and in response to an evaluation that the priority meets the threshold condition, whether the one or more shared resources is available to meet the request. The method can further include completing, by the at least one processor and in response to a determination that the one or more shared resources is available, execution of the one or more processes. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.

Abstract: A processing system monitors and synchronizes parallel execution of workgroups (WGs). One or more of the WGs perform (e.g., periodically or in response to a trigger such as an indication of oversubscription) a waiting atomic instruction. In response to a comparison between an atomic value produced as a result of the waiting atomic instruction and an expected value, WGs that fail to produce a correct atomic value are identified as being in a waiting state (e.g., waiting for a synchronization variable). Execution of WGs in the waiting state is prevented (e.g., by a context switch) until corresponding synchronization variables are released.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: The embodiments herein relate to a substrate coated with a multi-layer coating system including: optionally a primer layer applied to the substrate and deposited from a primer coating composition; a tie-coat layer applied to the substrate or to the optional primer layer, deposited from a tie-coat composition including a binder polymer obtainable by copolymerizing a mixture of ethylenically unsaturated monomers, the binder polymer having curable alkoxysilyl functional groups. The substrate can include a topcoat layer applied to the tie-coat layer, and deposited from a non-aqueous liquid foul release coating composition including a curable resin system including i) a curable polymer and optionally ii) a curing agent and/or a catalyst, where the non-aqueous liquid foul release coating composition is essentially free of a curable polysiloxane.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: A processing system includes a scheduling mechanism for producing data for fine-grained reordering of workgroups of a kernel to produce blocks of data, such as for communication across devices to enable overlapping of a producer computation with an all-reduce communication across the network. This scheduling mechanism enables a first parallel processor to schedule and execute a set of workgroups of a producer operation to generate data for transmission to a second parallel processor in a desired traffic pattern. At the same time, the second parallel processor schedules and executes a different set of workgroups of the producer operation to generate data for transmission in a desired traffic pattern to a third parallel processor or back to the first parallel processor.

Abstract: An anti-aging cosmetic composition including resveratrol and/or a derivative of resveratrol in combination with honokiol and/or magnolol. These molecules can be obtained from plant extracts. Both honokiol and magnolol are present in magnolia bark. A cosmetic treatment method is related including the application to the skin or skin appendages of the cosmetic composition.

Abstract: Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.

Abstract: The present invention provides methods, compositions and kits for assembling an enzyme-deoxyribonucleic acid (DNA) complex for use in preparing a double stranded DNA molecule comprising one or more loci of interest for determining the methylation status of the one or more loci of interest therein.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: Techniques to facilitate compression of depth data and real-time reconstruction of high-quality light fields. A parameter space of values for a line, pairs of endpoints on different sides of the line, and a palette index for each pixel of a pixel tile of a depth image is sampled. Values for the line, the pairs of endpoints, and the palette index that minimize an error are determined and stored.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.