Abstract: A network, such as a computer network, is disclosed. The network has a plurality of nodes and includes a first node for storing pieces of a digital object and having a storage. A plurality of connections are present between the first node and the plurality of nodes. The first node has a requester for requesting one or more pieces of the digital object, a transmitter for transferring one or more pieces of the digital object to at least one further node among the plurality of nodes, a receiver for receiving content availability messages from at least some of the plurality of nodes, and a sender for sending a limited content availability message to at least one further node among the plurality of nodes. The limited content availability message indicates a subset but not all of the pieces of the digital object available through the first node.

Abstract: Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Structure coated with a biocidal foul release coating system, the structure being obtained by a. providing a substrate, b. coating the substrate with a first coating layer, c. applying at least one subsequent coating layer on top of the first coating layer, the first coating layer containing a biocide, the subsequent coating layer(s) containing less biocide than the first coating layer and which is(are)free or substantially free of biocide, and wherein the first and the subsequent coating layer(s) form a biocidal foul release coating system showing a controlled leaching of the biocide.

Abstract: Systems and methods for facilitating diagnosis and product identification for patients requiring continence products. Embodiments of the invention have been particularly developed there by to provide a software application (for example an iOS or Android application) thereby to assist a clinician and/or patient in identifying appropriate continence products for a given set of patient requirements. While some embodiments will be described herein with particular reference to that application, it will be appreciated that the invention is not limited to such a field of use, and is applicable in broader contexts.

Abstract: A dental implant comprising an implant body which has an asymmetric root portion receivable in an asymmetric open root cavity of the patient and engagement means on the asymmetric root portion to at least in part engage a surface of the root cavity so as to prevent or inhibit unintentional extraction. The asymmetric root portion is complementarily shaped to fit the said asymmetric open root cavity, thus substantially dispensing with the need for protracted preparation of the root cavity and providing substantially immediate stability for the prosthetic tooth.

Abstract: A method for selecting a preferred cache for the download of digital data from a plurality of caches is disclosed. The method comprises the steps of requesting an address of the preferred cache and selecting the preferred cache from the plurality of caches. The selection of the preferred cache is derived from a location identifier of a client requesting the download of the digital data.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: A network and method for the delivery of digital data is disclosed having at least one peer (102a) downloading the digital data from a plurality of data sources (102, 312), at least one data monitoring device (800) for monitoring at least one quality of service parameter for the delivery of the digital data and at least one data delivery controller (810) for adjusting at least one of the rates for the delivery of the digital data from at least one of the plurality of data sources (102, 312).

Abstract: A spherical object is disclosed provided with a map substantial covering its entire surface wherein the map represents only a portion of the Earth such as a town, city, district, county, state or country. A label is also disclosed provided comprising a series of biconvex shapes which collectively describe such a map.

Abstract: A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in the subject's body is sufficient to block opiate effects, having the subject make one of the problem responses from which the subject suffers in the presence of stimuli similar to those to which it had been learned, after the amount of naloxone is no longer sufficient to block opiate effects, having the subject make healthy eating responses to food items that do not trigger the problem responses; and continuing the steps of administration of naloxone and having one after another of the problem responses made, followed by having a naloxone-free period in which healthy eating occurs, until the problem responses are extinguished.

Abstract: The determination of wax crystal particle size and population is used to monitor the performance of wax crystallizers used in lubricant oil processing using solvent dewaxing. The wax crystal particle size is monitored using online measurements. The information obtained from on-line monitoring is then used to control crystallization in the dewaxing equipment in order to optimize performance of the dewaxing units.

Abstract: The invention pertains to an antifouling coating composition including 20-100% by weight, calculated on the total amount of film-forming components, of a film-forming polymer (A) having an acrylic backbone bearing at least one terminal group of the formula: wherein X represents M is a metal of Group Ib, IIa, IIb, IIIa, IIIb, IVa, IVb, Va, VIa, VIb, VIIa, and VIII of the Periodic Table with a valency of 2 or more and a degree of ionisation less than that of the alkali metals metal; n is an integer of 1 to 2; R represents an organic residue selected from and R1 is a monovalent organic residue, and 80-0% by weight, calculated of polymer (B) a copper-based biocide for aquatic organisms wherein the antifouling coating composition is substantially free of any biocidal zinc compounds and substantially free of rosin, and in that the copper-based biocide has a metallic copper content below 2% by weight, based on the total weight of the copper-based biocide.

Abstract: A method for the distribution of digital objects (370) in a peer-to-peer network is disclosed. The digital objects (370) are distributed in a plurality of pieces (371-373). At least some of a plurality of peers (40a-d) are connected to other ones of the plurality of peers (40a-d) and at least one of the peers (40a-d) is connected to at least one cache (30).

Abstract: The invention relates to a content distribution network for the distribution of a digital object in a peer-to-peer network with a plurality of peers having a peer location identifier and a download client (103a) for downloading the digital object. A of distributed caches (312a, 312b) is present in the peer-to-peer network. At least some of the plurality of peers (102a, 102b, 102c) are connected to at least some of the plurality of distributed caches (312). A private tracker for managing the distribution of the digital object among the plurality of distributed caches (312a, 312b) and a public tracker for managing the distribution of the digital object between the plurality of peers (102a, 102b, 102c) are present.

Abstract: A network (10), such as a computer network, is disclosed. The network (10) has a plurality of nodes (20; 120) and includes a first node (30, 130) for storing pieces of a digital object and having a storage (40, 50; 140, 150). A plurality of connections are present between the first node (30, 130) and the plurality of nodes (20; 120). The first node (30, 130) has a requester for requesting one or more pieces of the digital object, a transmitter for transferring one or more pieces of the digital object to at least one further node among the plurality of nodes (20; 120), a receiver for receiving content availability messages from at least some of the plurality of nodes, and a sender for sending a limited content availability message to at least one further node (20; 120) among the plurality of nodes (20, 120). The limited content availability message indicates a subset but not all of the pieces of the digital object available through the first node (30; 130).

Abstract: A network and method for the delivery of digital data is disclosed having at least one peer (102a) downloading the digital data from a plurality of data sources (102, 312), at least one data monitoring device (800) for monitoring at least one quality of service parameter for the delivery of the digital data and at least one data delivery controller (810) for adjusting at least one of the rates for the delivery of the digital data from at least one of the plurality of data sources (102, 312).

Abstract: A method for selecting a preferred cache (312a) for the download of digital data from a plurality of caches (312; 312a-312d) is disclosed. The method comprises the steps of requesting an address of the preferred cache (312a) and selecting the preferred cache (312a) from the plurality of caches (312a). The selection of the preferred cache (312a) is derived from a location identifier of a client (102) requesting the download of the digital data.