Abstract: Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

Abstract: Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.

Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: The invention relates to a cosmetic use of an association of (i) resveratrol or a derivative thereof and (ii) betaine or a derivative thereof, or of a composition containing said association in a physiologically acceptable medium, to fight against the signs of ageing of the skin.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.

Abstract: A first workgroup is preempted in response to threads in the first workgroup executing a first wait instruction including a first value of a signal and a first hint indicating a type of modification for the signal. The first workgroup is scheduled for execution on a processor core based on a first context after preemption in response to the signal having the first value. A second workgroup is scheduled for execution on the processor core based on a second context in response to preempting the first workgroup and in response to the signal having a second value. A third context it is prefetched into registers of the processor core based on the first hint and the second value. The first context is stored in a first portion of the registers and the second context is prefetched into a second portion of the registers prior to preempting the first workgroup.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+.

Abstract: Compositions allowing the stimulation of hyaluronic acid synthesis via an increase in has-2 expression and their use in the treatment of conditions related to a decrease in hyaluronic acid synthesis.

Abstract: The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.

Abstract: Systems, methods, and articles of manufacture are disclosed that enable the compression of depth data and real-time reconstruction of high-quality light fields. In one aspect, spatial compression and decompression of depth images is divided into the following stages: generating a quadtree data structure for each depth image captured by a light field probe and difference mask associated with the depth image, with each node of the quadtree approximating a corresponding portion of the depth image data using an approximating function; generating, from the quadtree for each depth image, a runtime packed form that is more lightweight and has a desired maximum error; and assembling multiple such runtime packed forms into per-probe stream(s); and decoding at runtime the assembled per-probe stream(s). Further, a block compression format is disclosed for approximating depth data by augmenting the block compression format 3DC+(BC4) with a line and two pairs of endpoints.

Abstract: Provided herein are secretory compositions/cocktails derived from a novel, extremophilic fungal species cultured, isolated, characterized and sequenced herein. Said novel, extremophilic fungal species may be exploited to produce a secretory compositions/cocktails which comprise a unique mixture of thermo-tolerant, stable enzymes capable of digesting cellular and genetic material in its surroundings under extreme temperatures. Such secretory compositions/cocktails may be useful as cleaning and sterilization solutions against biofilm, urine, yeast, bacterial, or viral contamination. Other uses include, but are not limited to, urea removal, fertilizer wastewaters, wastewater reclamation for life support systems in space, pH control, source of ammonia and carbon dioxide, starch digestion, biofuel production, as pharmaceuticals, and medical treatments such as wounds, skin disorders, or nail disorders.

Abstract: Enzyme-based systems and methods for synthesizing the NAD precursors NMN and NaMN are disclosed. Such methods and systems utilize a mutated form of phosphoribosylpyrophosphate synthetase (PRS) that is superactive and/or other enzyme or enzyme combinations that are immobilized onto a solid surface. The methods and systems substantially increase the efficiency and yield of NAD precursor synthesis.

Abstract: A method of rendering content items on a display via an electronic device involves mapping linked content items to a three-dimensional object defined by layout data. The layout data is then transmitted to an electronic device for display.

Abstract: In vivo methods using bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.

Abstract: Systems, methods, and articles of manufacture for real-time rendering using compressed animated light fields are disclosed. One embodiment provides a pipeline, from offline rendering of an animated scene from sparse optimized viewpoints to real-time rendering of the scene with freedom of movement, that includes three stages: offline preparation and rendering, stream compression, and real-time decompression and reconstruction. During offline rendering, optimal placements for cameras in the scene are determined, and color and depth images are rendered using such cameras. Color and depth data is then compressed using an integrated spatial and temporal scheme permitting high performance on graphics processing units for virtual reality applications.

Abstract: Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.

Abstract: Compositions allowing the stimulation of hyaluronic acid synthesis via an increase in has-2 expression and their use in the treatment of conditions related to a decrease in hyaluronic acid synthesis.

Abstract: Enzyme-based systems and methods for synthesizing the NAD precursors NMN and NaMN are disclosed. Such methods and systems utilize a mutated form of phosphoribosylpyrophosphate synthetase (PRS) that is superactive and/or other enzyme or enzyme combinations that are immobilized onto a solid surface. The methods and systems substantially increase the efficiency and yield of NAD precursor synthesis.