Abstract: A three-dimensional layered video platform for remotely rendering a high-fidelity experience is provided for virtualizing an environment to provide improved communication and conferencing between participants. The three-dimensional layered video platform for remotely rendering high-fidelity assets may include a local layer, high-fidelity layer, peer-to-peer communication layer, interface, and interoperability between layers. Additional layers may be added over time. A method for virtualizing an environment to provide improved communication and conferencing and/or video content delivery between participants using the three-dimensional layered video platform for remotely rendering a high-fidelity experience is also provided.

Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.

Abstract: Robotic medical systems may perform robotic movement that is saturated according to one or more constraints of the system. A robotic system can include a robotic arm configured to control a medical instrument. The robotic system can receive a first user input from a user for moving the robotic arm to control the medical instrument. The robotic system can guide the movement of the robotic arm along a collision boundary surrounding an object in accordance with the first user input and one or more secondary constraints.

Abstract: The invention concerns a detergent composition, comprising: (a) from 0.5 to 40 wt. % of alignin derived anionic surfactant, wherein the lignin derived anionic surfactant has the following structure (1) or (2), preferably (1): Formula (1) or, Formula (2) wherein: M is a counterion; R1 and R2 are alkyl or alkenyl groups, each either linear or branched; the alkyl or alkyenyl groups R1 and R2 added together contain from 5 to 15 carbon atoms; with the proviso that R1 and R2 each contain at least 1 carbon atom; the invention also concerns a method, preferably a domestic method of treating a textile.

Abstract: Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device (100) configured in accordance with embodiments of the present technology can include an anchoring member (104) coupled to a flexible, compliant damping member (102) including a generally tubular sidewall having an outer surface (115), an inner surface (113) defining a lumen configured to direct blood flow, a first end portion (106) and a second end portion (108), and a damping region (120) between the first and second end portions (106, 108). The inner and outer surfaces (113, 115) of the damping member (102) can be spaced apart by a distance that is greater at the damping region (120) than at either of the first or second end portions (106, 108).

Abstract: Embodiments generate state elements based on application requests from a client. The state elements may be enqueued in a state queue associated with an application session for an application requests and the application requests may be forwarded to the application. Application responses from the application may be employed to perform further actions, including: generating message elements based on the application responses such that the message elements may be enqueued in a message queue associated in the application session; determining a portion of the state elements in the state queue that may be associated the message elements; updating the portion of the state elements to advance a protocol state based on the message elements such that the application responses may be communicated to the client.

Abstract: Devices, systems, and methods for combinatorial treatment of a condition with an implantable damping device and therapeutic agent (e.g., drug) are disclosed herein. Methods for treating one or more effects of the condition, such as a neurological condition, include providing the implantable damping device and at least one other therapy, such as a therapeutic agent, that treats the condition to the patient. The implantable damping device includes a flexible damping member and an abating substance and can be placed in apposition with a blood vessel. The flexible damping member forms a generally tubular structure having an inner and an outer surface, the inner surface formed of a sidewall having a partially deformable portion. The abating substance is disposed within the partially deformable portion and moves longitudinally and/or radially within the partially deformable portion in response to pulsatile blood flow.

Abstract: The invention provides a novel compound having the general formula (I) or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.

Abstract: The invention relates to a detergent composition comprising: from 0.5 to 50 wt. % of a C12-C14, alkyl ethoxylated sulfate surfactant; wherein the alkyl ethoxylated sulfate surfactant comprises a C14 alkyl group at a level of at least 50 wt. % of the alkyl ethoxylated sulfate surfactant; wherein the average degree of ethoxylation (EO) is from 2.5 to 3.5; wherein with reference to the wt. % of the total ethoxylated portion of said alkyl ethoxylated sulfate surfactant, the level of 1EO is from 10 to 25 wt. %, the level of 2EO is from 15 to 24 wt. %, the level of 3EO is from 20 to 35 wt. %, and the level of 4EO is from 12 to 25 wt. %; and, wherein the C12-C14 alkyl ethoxylated sulfate surfactant includes at most 10 wt. % alkyl chains of C15 and higher; the invention also relates to the use and method to enhance the foaming of a detergent composition by inclusion of said specified alkyl ethoxylated sulfate surfactant.

Abstract: A robotic surgical system can include one or more adjustable arm supports that support one or more robotic arms. The adjustable arm supports and/or robotic arms can be configured to be deployed from low mount positions, for example, from positions below the surface of the table. The robotic arms can include a plurality of joints providing a plurality of degrees of freedom. The joints may be grouped into a proximal shoulder, an elbow, and a distal wrist. The robotic arms can include one or more redundant degrees of freedom. An insertion mechanism, associated with the robotic arm and configured for providing insertion of an instrument along an assertion axis, can be provided at a distal end of the robotic arms.

Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.

Abstract: The invention provides, for example, a novel compound having the general formula (I): or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.

Abstract: Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device (100) configured in accordance with embodiments of the present technology can include an anchoring member (104) coupled to a flexible, compliant damping member (102) including a generally tubular sidewall having an outer surface (115), an inner surface (113) defining a lumen configured to direct blood flow, a first end portion (106) and a second end portion (108), and a damping region (120) between the first and second end portions (106, 108). The inner and outer surfaces (113, 115) of the damping member (102) can be spaced apart by a distance that is greater at the damping region (120) than at either of the first or second end portions (106, 108).

Abstract: A robotically enabled teleoperated system can include a controller and a robotic tool capable of manipulation by the controller. The controller can include a handle, a gimbal and a positioning platform. The handle can be configured for actuation by an operator to cause a corresponding manipulation of the robotic tool. The gimbal can include a joint and a load cell. The joint can be configured to be manipulated based on an impedance control, such that manipulation of the gimbal causes a corresponding manipulation of the robotic tool based on a displacement of the joint. A portion of the positioning platform can be configured to be manipulated based on an admittance control, such that manipulation of the positioning platform causes a corresponding manipulation of the robotic tool based on a force imparted on the controller and measured by the load cell.

Abstract: Systems and methods for performing concomitant medical procedures are disclosed. In one aspect, the method involves controlling a first robotic arm to insert a first medical instrument through a first opening of a patient and controlling a second robotic arm to insert a second medical instrument through a second opening of the patient. The first robotic arm and the second robotic arm are part of a first platform and the first opening and the second opening are positioned at two different anatomical regions of the patient.

Abstract: A device (15, 50, 55, 60, 100, 200) for altering blood flow characteristics in a vessel (20), the device (15, 50, 55, 60, 100, 200) comprising: a cuff (10) configured to be surgically positioned around a portion of the vessel (20); a first pad (40) located on an internal wall of the cuff (10), wherein the pad (40): locally reduces a cross-sectional area of a passageway (25) extending through the cuff (10) and/or defines a passageway (25) within the cuff (10) which is non-linear.

Abstract: A robotically enabled teleoperated system can include a controller and a robotic tool capable of manipulation by the controller. The controller can include a handle, a gimbal and a positioning platform. The handle can be configured for actuation by an operator to cause a corresponding manipulation of the robotic tool. The gimbal can include a joint and a load cell. The joint can be configured to be manipulated based on an impedance control, such that manipulation of the gimbal causes a corresponding manipulation of the robotic tool based on a displacement of the joint. A portion of the positioning platform can be configured to be manipulated based on an admittance control, such that manipulation of the positioning platform causes a corresponding manipulation of the robotic tool based on a force imparted on the controller and measured by the load cell.

Abstract: Certain aspects relate to systems and techniques for medical robotic systems that leverage a versatile, open kinematic chain together with a set of medical-procedure-specific software-controlled actuation constraints in order to perform a variety of medical procedures. The robotic system can be operated in a first mode by identifying a remote center and constraining the actuation of motorized joints to maintain intersection of at least an insertion axis with the remote center. The robotic system can be operated in a second mode by identifying a virtual rail position and constraining the actuation of motorized joints to maintain alignment of the insertion axis along the virtual rail.

Abstract: The invention provides novel compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as described herein. The compound of formula (I) can be used as a medicament.

Abstract: Systems and methods for performing concomitant medical procedures are disclosed. In one aspect, the method involves controlling a first robotic arm to insert a first medical instrument through a first opening of a patient and controlling a second robotic arm to insert a second medical instrument through a second opening of the patient. The first robotic arm and the second robotic arm are part of a first platform and the first opening and the second opening are positioned at two different anatomical regions of the patient.