Abstract: Certain aspects relate to systems and techniques for medical robotic systems that leverage a versatile, open kinematic chain together with a set of medical-procedure-specific software-controlled actuation constraints in order to perform a variety of medical procedures. The robotic system can be operated in a first mode by identifying a remote center and constraining the actuation of motorized joints to maintain intersection of at least an insertion axis with the remote center. The robotic system can be operated in a second mode by identifying a virtual rail position and constraining the actuation of motorized joints to maintain alignment of the insertion axis along the virtual rail.

Abstract: Systems and methods for performing concomitant medical procedures are disclosed. In one aspect, the method involves controlling a first robotic arm to insert a first medical instrument through a first opening of a patient and controlling a second robotic arm to insert a second medical instrument through a second opening of the patient. The first robotic arm and the second robotic arm are part of a first platform and the first opening and the second opening are positioned at two different anatomical regions of the patient.

Abstract: A device for treating heart failure in a patient. The device comprising a body, at least one passage through the body, at least one one way valve in the passage and a mounting means adapted for mounting the body in an opening provided in the patient's atrial septum. In use, the device is oriented such that, when the patient's left atrial pressure exceeds the patient's right atrial pressure by a predetermined amount, the one way valve(s) opens to allow blood flow through the passage(s) from the left atrium to the right atrium to thereby reduce the left atrial pressure.

Abstract: The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R4 and A are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: A wheelchair anchor system for a vehicle, the wheelchair anchor system comprising a support surface configured to support a portion of a wheelchair; a floor mount configured to secure a portion of the wheelchair to a surface of the vehicle; an attachment mechanism for securing a portion of the wheelchair to the floor mount; and a harness configured to secure an occupant of the wheelchair.

Abstract: The invention provides novel compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R2?, R3, R4 and R5 are as described herein. The compound of formula (I) can be used as a medicament.

Abstract: Robotic medical systems can be capable of kinematic optimization using shared robotic degrees-of-freedom. A robotic medical system can include a patient platform, an adjustable arm support coupled to the patient platform, and at least one robotic arm coupled to the adjustable arm support. The at least one robotic arm can be coupled to a medical tool. The robotic medical system includes a first link and a second link. Each of the first link and the second link includes a first end coupled to the adjustable arm support and a second end coupled to a base of the patient platform, for rotating the adjustable arm support relative to the patient platform. The robotic medical system can also include a processor configured to adjust a position of the adjustable arm support and the at least one robotic arm while maintaining a remote center of movement of the medical tool.

Abstract: Certain aspects relate to systems and techniques for medical robotic systems that leverage a versatile, open kinematic chain together with a set of medical-procedure-specific software-controlled actuation constraints in order to perform a variety of medical procedures. The robotic system can be operated in a first mode by identifying a remote center and constraining the actuation of motorized joints to maintain intersection of at least an insertion axis with the remote center. The robotic system can be operated in a second mode by identifying a virtual rail position and constraining the actuation of motorized joints to maintain alignment of the insertion axis along the virtual rail.

Abstract: The invention relates to a compound of formula (I) Wherein A, L, R1, R2, R3 and R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: Embodiments are directed to credential management for distributed services. A plurality of mesh agents for an overlay network may be provided such that the overlay network may be employed to provide a secure tunnel between a client and a resource server. If client request that requires user credentials is provided to a mesh agent associated with the resource server, credential instructions may be provided to the mesh agent and the credential instructions may be employed to determine credential information that enables access to the resource server. The mesh agent may be employed to communicate the client request and the credential information to the resource server; determining a response to the client request from the resource server; employing the mesh agent to receive a response to the client request from the resource server and forwarded to the client over the overlay network.

Abstract: The present invention features a sensor implant that can adhere to bone. The sensing device is capable of sensing bone strains and reporting them as well as loads passing through bone for extended periods of time. The sensor implant can also be used to monitor bone growth for bone segmental repair of long bones or to monitor changes in bone characteristics of patients with osteoporosis. The present technology has the potential to give physicians the ability to predict when a patient with osteoporosis has an impending fracture and thus be able to intervene and prevent further damage.

Abstract: Robotic medical systems can be capable of kinematic optimization using shared robotic degrees-of-freedom. A robotic medical system can include a patient platform, an adjustable arm support coupled to the patient platform, and at least one robotic arm coupled to the adjustable arm support. The at least one robotic arm can be coupled to a medical tool. The robotic medical system includes a first link and a second link. Each of the first link and the second link includes a first end coupled to the adjustable arm support and a second end coupled to a base of the patient platform, for rotating the adjustable arm support relative to the patient platform. The robotic medical system can also include a processor configured to adjust a position of the adjustable arm support and the at least one robotic arm while maintaining a remote center of movement of the medical tool.

Abstract: The invention concerns a detergent composition, comprising: (a) from 1 to 40 wt. % of a secondary alkane sulfonate surfactant with an average of 15 to 18 carbon atoms in a linear alkane chain; (b) from 1 to 40 wt. % of an anionic surfactant other than a); and, (c) from 0.01 to 8%, of an alkyl hydroxysultaine co-surfactant; and wherein greater than 50 wt. % of the alkyl chain of the secondary alkane sulfonate is C15 to C18, secondary alkane sulfonate; the invention also concerns a method, preferably a domestic method of treating a textile.

Abstract: The invention relates to a secondary alkane sulfonate surfactant, wherein wherein greater than 50 wt. % of the secondary alkane sulfonate is C17 and/or C18 secondary alkane sulfonate; the invention also concerns a detergent composition comprising the secondary alkane sulfonate surfactant; the invention also concerns a method, preferably a domestic method of treating a textile.

Abstract: The invention concerns a detergent composition, comprising: (a) from 1 to 40 wt. % of a secondary alkane sulfonate surfactant with an average of 15 to 18 carbon atoms in a linear alkane chain; (b) from 1 to 40 wt. % of an nonionic surfactant; and, (c) from 0.01 to 8%, of an alkyl hydroxysultaine co-surfactant; wherein the total weight ratio of total weight of anionic surfactants to total weight of nonionic surfactants ranges from 30:1 to 1:2; and, wherein the hydroxy sultaine cosurfactant has the formula: R-N+(CH3)2—CH2—CH(OH)—CH2—SO3—M+ where R is an alkyl chain with C10-C18 and M is any suitable cationic counterion; the invention also concerns a method, preferably a domestic method of treating a textile.

Abstract: The invention relates to a secondary alkane sulfonate surfactant, wherein at least 70 wt. % of the secondary alkane sulfonate is a secondary alkane sulfonate (SAS) surfactant having linear alkyl chains of from 15 to 18 carbon atoms; wherein less than 30% of the secondary alkane sulfonate (SAS) surfactant has linear alkyl chains of 14 carbon atoms or lower; the invention also concerns a detergent composition comprising the secondary alkane sulfonate surfactant; the invention also concerns a method, preferably a domestic method of treating a textile.

Abstract: Use of a furan-based surfactant in a detergent for reducing or preventing irritancy during use.

Abstract: A device for treating heart failure in a patient. The device comprising a body, at least one passage through the body, at least one one way valve in the passage and a mounting means adapted for mounting the body in an opening provided in the patient's atrial septum. In use, the device is oriented such that, when the patient's left atrial pressure exceeds the patient's right atrial pressure by a predetermined amount, the one way valve(s) opens to allow blood flow through the passage(s) from the left atrium to the right atrium to thereby reduce the left atrial pressure.

Abstract: The present disclosure provides recombinant adeno-associated virus virions with variant capsid protein, where the recombinant AAV (rAAV) virions exhibit one or more of increased ability to cross neuronal cell barriers, increased infectivity of a neural stem cell, increased infectivity of a neuronal cell, and reduced susceptibility to antibody neutralization, compared to a control AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a neural stem cell or a neuronal cell in an individual. The present disclosure also provides methods of modifying a target nucleic acid present in a neural stem cell or neuronal cell.