Abstract: The systems and methods disclosed herein are directed to robotically controlling a medical device to utilize manual skills and techniques developed by surgeons. The system can include an emulator representing a medical device. The system can include at least one detector configured to track the emulator. The system can also include an imaging device configured to track the medical device. The system may be configured to move the medical device to reduce an alignment offset between the location of the emulator and the location of the medical device, to move the imaging device based on the translational movement of the emulator, and/or to move the medical device based on data indicative of an orientation of the emulator.

Abstract: Devices, systems, and methods for combinatorial treatment of a condition with an implantable damping device and biologic therapeutic agent are disclosed herein. Methods for treating one or more effects of the condition, such as a neurological condition, include providing the implantable damping device and at least one other therapy, such as a biologic therapeutic agent, that treats the condition to the patient. The implantable damping device includes a flexible damping member and an abating substance and can be placed in apposition with a blood vessel. The flexible damping member forms a generally tubular structure having an inner and an outer surface, the inner surface formed of a sidewall having a partially deformable portion. The abating substance is disposed within the partially deformable portion and moves longitudinally and/or radially within the partially deformable portion in response to pulsatile blood flow.

Abstract: Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.

Abstract: Certain aspects relate to systems and techniques for aligning inputs on medical instruments. In one aspect, the method includes receiving, at a data reader of the instrument drive mechanism, alignment data from the tool when the tool is positioned within a threshold distance of the data reader. The tool include one or more inputs and one or more pull wires configured to be actuated by output shafts of the instrument drive mechanism via the one or more inputs. The method also includes receiving, at a processor, the alignment data from the data reader, and rotating, via the processor, the one or more output shafts of the instrument drive mechanism into alignment with the one or more inputs of the tool based on the alignment data. Each of the output shafts is configured to mechanically couple with a corresponding one of the inputs of the tool.

Abstract: Allowing a network function (such as a router, firewall or SD-WAN endpoint) or service chain of network functions to transparently access a network uplink, while also allowing a set of management entities to access the same link without interference or configuration. To the extent that a conflict arises between ports allocated to the management functions and to the network functions, the relevant port is automatically removed from use by management functions and allocated to network functions to end the conflict.

Abstract: Brush, in particular toilet brush, with a brush head and a handle. The brush head can be detachably pushed onto the handle. The handle has a release mechanism for the brush head.

Abstract: A transaction terminal provides processing for payment using a cryptocurrency during a transaction being conducted at the transaction terminal. The transaction terminal further provides processing for a refund transaction utilizing cryptocurrency.

Abstract: The application provides a compound having the general formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: An apparatus comprises a processing platform implementing a data set discovery engine and a data set valuation engine. The data set discovery engine is configured to generate data set similarity measures each relating a corresponding one of a plurality of data sets to one or more other ones of the plurality of data sets. The data set valuation engine is coupled to the data set discovery engine and configured to generate valuation measures for respective ones of at least a subset of the plurality of data sets based at least in part on respective ones of the data set similarity measures generated by the data set discovery engine. For example, the data set valuation engine may generate the valuation measure for a given data set as a function of valuation measures previously generated for respective other data sets determined to exhibit at least a threshold similarity to the given data set.

Abstract: Embodiments are directed to credential management for distributed services. A plurality of mesh agents for an overlay network may be provided such that the overlay network may be employed to provide a secure tunnel between a client and a resource server. If client request that requires user credentials is provided to a mesh agent associated with the resource server, credential instructions may be provided to the mesh agent and the credential instructions may be employed to determine credential information that enables access to the resource server. The mesh agent may be employed to communicate the client request and the credential information to the resource server; determining a response to the client request from the resource server; employing the mesh agent to receive a response to the client request from the resource server and forwarded to the client over the overlay network.

Abstract: A fabric softener composition comprising: a. 1 to 20 wt. % ionic compound of general formula I: (I) wherein b. 0.1 to 20 wt. % fatty co-softener; and c. Water.

Abstract: The invention provides novel compounds as described herein, compositions including the compounds and methods of using the compounds.

Abstract: A system, method, and computer readable medium for managing service mesh for container instances. The method includes generating a service mesh that includes a plurality of computing resources. The method further includes obtaining, from an instantiated computing resource, a request to associate the computing resource with another computing resource in the service mesh, where the request comprising a set of constraints that allows the other computing resource to be identified. Based on the set of constraints, the computing resources in the service mesh are connected in which the computing resources communicate with each other through a dedicated proxy.

Abstract: The invention provides a novel compound having the general formula (I) or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.

Abstract: The invention provides a novel compound having the general formula (I) wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: A fabric softener composition comprising: a. 1 to 20 wt. % ionic compound of general formula I: (I) b. 0.1 to 30 wt. % perfume; and c. Water.

Abstract: Methods and apparatus for cleaning a surface with a cleaning device having a body with a handle, a connector, and one or more cleaning heads that are removably attached to the cleaning device. Each cleaning head include a lower surface arranged to contact a surface to be cleaned and a dirt collection chamber permanently attached to the cleaning head. The cleaning head may include a support structure to support the dirt collection chamber and a cleaning sheet. The cleaning head also may include a suction nozzle. At least a portion of the dirt collection chamber may be made of a filter material.

Abstract: Robotic medical systems may perform robotic movement that is saturated according to one or more constraints of the system. A robotic system can include a robotic arm configured to control a medical instrument. The robotic system can receive a first user input from a user for moving the robotic arm to control the medical instrument. The robotic system can guide the movement of the robotic arm along a collision boundary surrounding an object in accordance with the first user input and one or more secondary constraints.

Abstract: Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device (100) configured in accordance with embodiments of the present technology can include an anchoring member (104) coupled to a flexible, compliant damping member (102) including a generally tubular sidewall having an outer surface (115), an inner surface (113) defining a lumen configured to direct blood flow, a first end portion (106) and a second end portion (108), and a damping region (120) between the first and second end portions (106, 108). The inner and outer surfaces (113, 115) of the damping member (102) can be spaced apart by a distance that is greater at the damping region (120) than at either of the first or second end portions (106, 108).