Abstract: The present invention is novel 2-isopropoxy-N-1H-tetrazol-5-yl-benzamides having unexpected inhibition of histamine release from human basophils.

Abstract: The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.

Abstract: The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.

Abstract: Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.

Abstract: Novel acidic indole compounds having use as antiallergic agents, methods of synthesis, compositions, and uses are claimed.

Abstract: Cycloheptadiene analogues of arachidonic acid as well as their cyclopropyl intermediates are described as inhibiting human leukocyte lipoxygenase and antagonizing SRS-A. Methods of manufacture and pharmaceutical compositions are described. The compounds are useful in treating allergic diseases, cardiovascular diseases and immunoinflammatory diseases.

Abstract: Anticholinergic 3-[2-(azabicyclo)ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin -5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.

Abstract: Anticholinergic 3-[2-(mono- and dialkylamino)-propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]-pyridin- 5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.A method for preparing the intermediate which is required to prepare the unsubstituted benzopyrano-[3,4-c]pyridin-5-ones of the invention is also disclosed.

Abstract: This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthmatic reactions.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: The present invention relates to (2-oxo-2H-1-benzopyran-3-yl)aminooxoacetic acids and their derivatives having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro and R.sub.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts thereof; these compounds are indicated in the management of allergic manifestations such as, for example, asthma, hay fever and the like.The present invention relates to (2-oxo-2H-1-benzopyran-3-yl)aminooxoacetic acids and their derivatives having the following structural formula: ##STR2## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro. R.sub.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts thereof.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Abstract: This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthamatic reactions.

Abstract: The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 2-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl, or nitro and R.sub.2 is hydrogen or lower alkyl and the pharmaceutically acceptable salts thereof.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.

Abstract: The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 3-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro and R.sub.2 is hydrogen or lower alkyl.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.

Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.

Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.

Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.