Abstract: The invention relates to novel compounds having the formulas I and III: ##STR1## wherein, in formula I, X is -O- or -N-COR wherein R is lower alkyl or aryl, and Z is ##STR2## WHEREIN R' is hydrogen, halogen or alkoxy. The compounds of this invention are prepared by a novel process which involves the cyclization of the corresponding aryl(methylsulfinyl)methyl ketones. The compounds of this invention having formulas I and III are useful in the treatment of hyperacidity and for alleviating allergic manifestations.

Abstract: The present invention relates to 7-substituted triol derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The 7-substituted triol derivatives of acid S of this invention are useful as antifungal agents.

Abstract: There are disclosed 7-substituted-9-oxoxanthene-2-carboxaldehydes of the formula: ##STR1## in which R is lower alkoxy or hydroxy. These compounds are indicated in the management of allergic manifestations such as, for example, bronchial asthma or hay fever.

Abstract: Substituted 3-(2-pyridinyl)-4-(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or --CH.sub.2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.

Abstract: The present invention describes octahydro and decahydro derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The octahydro and dechydro derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##SPC1##wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.

Abstract: 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides of the formula I: ##SPC1##wherein R is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity.

Abstract: The present invention relates to triols derived from antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), to the acetates thereof and to processes for the production of the triols and corresponding acetates. These triols and acetates are potent antifungal agents inhibiting the growth of a variety of fungi, including H. capsulatum, T. mentagrophytes and M. fulvum.

Abstract: The present invention relates to keto and ketoxime derivatives of the novel antibiotic substance, acid S, produced by the microorganism Polyangium cellulosum var. fulvum (ATCC N0. 25532) and to processes for their preparation. The novel keto and ketoxime derivatives of acid S of this invention are useful antifungal agents.