Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: Compounds of formula I: ##STR1## wherein Y is hydrogen, lower alkyl, halogen or lower alkoxy; X is carboxy, alkoxycarbonyl, carboxamide, cyano or tetrazolo, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthmatic reactions.

Abstract: The present invention relates to dialkyl ({[3-(alkoxy-carbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)-pro panedioates having the following structural formula: ##STR1## wherein R.sub.1 is lower alkyl; and R.sub.2 is hydrogen, halogen, lower alkyl or nitro.These compounds exhibit antibacterial activity against gram positive and gram negative bacteria and are therefore useful in the treatment of bacterial infections caused by these organisms.

Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof. The compounds of the invention are active in the prevention of allergic and asthmatic reactions in mammals.

Abstract: The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents.

Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

Abstract: The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents.

Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC NO. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.

Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.This is a division of application Ser. No. 611,282 filed Sept. 8, 1975.

Abstract: The present invention relates to compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy or lower alkyl, R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl.These compounds, including their corresponding pharmaceutically acceptable salts, are useful in the management of allergic conditions such as hay fever and as a prophylactic in the treatment of bronchial asthma.

Abstract: Substituted 3-(2-pyridinyl)-4(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or --CH.sub.2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.

Abstract: The present invention relates to 4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-3-carboxylic acids, salts and esters having the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen, aralkyl or lower alkyl; R.sub.3 is hydrogen or lower alkyl and their pharmaceutically acceptable salts.These compounds are indicated in the management of allergic conditions such as bronchial asthma, hay fever and the like.

Abstract: Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyridineethanol 1-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, ortho-amino or ortho-lower alkylamino; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy or lower alkanoyloxy; the pharmaceutically acceptable acid addition salts thereof and a process for the preparation thereof are described. The compounds of this invention are useful in the prevention of allergic and asthmatic reactions.

Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

Abstract: There is disclosed 4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylic acids, salts and esters of the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen, aralkyl or lower alkyl; R.sub.3 is hydrogen or lower alkyl and their pharmaceutically acceptable salts.These compounds are useful in the management of allergic conditions such as bronchial asthma, hay fever and so on.

Abstract: The invention relates to novel compounds having the formulas I and III: ##STR1## wherein, in formula I, X is --O-- or --N--COR wherein R is lower alkyl or aryl, and Z is ##STR2## WHEREIN R' is hydrogen, halogen or alkoxy. the compounds of this invention are prepared by a novel process which involves the cyclization of the corresponding aryl(methylsulfinyl)methyl ketones. The compounds of this invention having formulas I and III are useful in the treatment of hyperacidity and for alleviating allergic manifestations.

Abstract: The present invention relates to 2-[1-imino-2-(methylsulfinyl)ethyl]phenols and 3-[1-imino-2-(methylsulfinyl)ethyl]-2-naphthalenols having the following structural formulas: ##STR1## wherein X is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; Y is hydrogen, lower alkyl or cycloalkyl.These compounds exhibit antibacterial activity, particularly against gram-positive bacteria, and are useful in the treatment of bacterial infections caused by these organisms.

Abstract: 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; the pharmaceutically acceptable, acid addition salts thereof; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.

Abstract: The present invention relates to cyclic and acyclic amide derivatives of the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATTC No. 25532), to the acetates thereof and to processes for the production of the amides and their corresponding diacetates. The amide derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: There is disclosed 2,3-dihydro-3-(2-pyridinyl)-4H-1-benzopyran-4-one N-oxides of the formula: ##STR1## in which R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy or amino; R.sub.2 is hydrogen or --CH.sub.2 OH. These compounds are indicated in the treatment of gastric ulcers.