Abstract: Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.

Abstract: Systems and methods are provided for imaging a target as for example a multiwell plate. A plurality of regions of interest are selected on the target at a system control. The selected plurality of regions of interest are simultaneously imaged to provide an image with the plurality of regions of interest selectively magnified by a microlens array (30) and the regions that are not of interest are rejected by means of a mirrored aperture array, a mask, or selective illumination of the regions of interest of the target.

Abstract: Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. A first optical assembly is configured to focus light received from the substantially bitelecentric lens assembly onto the detector. The substantially bitelecentric lens assembly and the first optical assembly are configured to produce a collimated light space between the substantially bitelecentric lens assembly and the first optical assembly. A second optical assembly is positioned within the collimated light space.

Abstract: A cooling apparatus includes a shared cooling device for one or more systems or components, and a plurality of primary cooling pathways. Each of the primary cooling pathways includes a transition duct and a fan. The transition duct is in fluid communication with the shared cooling device. The fan is in fluid communication with the transition duct.

Abstract: The present invention includes a thermal management system and method including: a drive shaft; one or more fans or impellers in fluid communication with at least a portion of the drive shaft; and one or more air management baffles configured to direct air flow between the impeller and the portion of the drive shaft. In one embodiment, the system and method further includes insulation positioned about the at least a portion of the drive shaft.

Abstract: A transition duct assembly includes a shared connector, and a plurality of primary cooling pathways for cooling one or more systems or components. Each primary cooling pathway includes a transition duct in fluid communication with the shared connector, and a transition connector in fluid communication with the transition duct.

Abstract: Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.

Abstract: Embodiments of the Concrete Form include a form tube, chamfer disk, and one or more cross-members. The cross-members are comprised of a center pivot aperture, two bolt guides, which are formed by the cross-members, end clamps, and an optional clamp. The chamfer disk is a disk that sits atop of the form tube and forms side chamfers in positive relief when placed upon the form tube when the concrete cures. The optional conduit clamp can be used to hold any conduit, tube or any other item during the pour. In another embodiment of the Concrete Form is comprised of a form tube, chamfer disk, end clamps, four or more bottom slide arms, and four or more top slide arms.

Abstract: A platform for providing authorization of electronic communication of secure data to external entities, e.g., vendors, third parties or the like based on an assessment of the data risk associated with communicating the data to the external entity. The secure data that is to be communicated, in the form of specific data items, are identified as well as the associated security standards. The external identity is assessed to ensure their capabilities to properly meet the enterprise/sender's information security, business privacy and continuity standards, along with applicable industry standards. Based on the results of the assessment, remediation action may be required to address critical vulnerabilities or recommendations may be presented to a decision-making entity to grant authorization to electronically communicate the data in question to the external entity. In response to granting authorization, secure communication channels are allocated and established to allow for communication of the data.

Abstract: Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. A first optical assembly is configured to focus light received from the substantially bitelecentric lens assembly onto the detector. The substantially bitelecentric lens assembly and the first optical assembly are configured to produce a collimated light space between the substantially bitelecentric lens assembly and the first optical assembly. A second optical assembly is positioned within the collimated light space.

Abstract: Embodiments of the Concrete Form include a form tube, chamfer disk, and one or more form cross-members. The form cross-members are comprised of a center pivot, two bolt guides, which are formed by the cross-members, and an optional clamp. The chamfer disk is a disk that sits atop of the form tube and forms side chamfers when placed upon the form tube when the concrete cures. The chamfer disk is a separate formed or molded piece that will sit on top of the tube form in order to form a chamfer in the concrete. The chanfer disk is a ring-shaped device with the chamfer formed in positive relief under the ring of the chamfer disk. The optional clamp can be used to hold any conduit, tube or any other item during the pour.

Abstract: Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. A first optical assembly is configured to focus light received from the substantially bitelecentric lens assembly onto the detector. The substantially bitelecentric lens assembly and the first optical assembly are configured to produce a collimated light space between the substantially bitelecentric lens assembly and the first optical assembly. A second optical assembly is positioned within the collimated light space.

Abstract: A platform for providing authorization of electronic communication of secure data to external entities, e.g., vendors, third parties or the like based on an assessment of the data risk associated with communicating the data to the external entity. The secure data that is to be communicated, in the form of specific data items, are identified as well as the associated security standards. The external identity is assessed to ensure their capabilities to properly meet the enterprise/sender's information security, business privacy and continuity standards, along with applicable industry standards. Based on the results of the assessment, remediation action may be required to address critical vulnerabilities or recommendations may be presented to a decision-making entity to grant authorization to electronically communicate the data in question to the external entity. In response to granting authorization, secure communication channels are allocated and established to allow for communication of the data.

Abstract: Approaches are described to improve database performance by implementing a RLE decompression function at a low level within a general-purpose processor or an external block. Specifically, embodiments of a hardware implementation of an instruction for RLE decompression are disclosed. The described approaches improve performance by supporting the RLE decompression function within a processor and/or external block. Specifically, a RLE decompression hardware implementation is disclosed that produces a 64-bit RLE decompression result, with an example embodiment performing the task in two pipelined execution stages with a throughput of one per cycle. According to embodiments, hardware organization of narrow-width shifters operating in parallel, controlled by computed shift counts, is used to perform the decompression.

Abstract: Systems and methods are provided for imaging a target as for example a multiwell plate. A plurality of regions of interest are selected on the target at a system control. The selected plurality of regions of interest are simultaneously imaged to provide an image with the plurality of regions of interest selectively magnified by a microlens array (30) and the regions that are not of interest are rejected by means of a mirrored aperture array, a mask, or selective illumination of the regions of interest of the target.

Abstract: Disclosed are fluorescent indicators and methods for detecting the activity of an ion channel or transporter in a cell. The indicators and methods may be used to measure influx or efflux of thallium through an ion channel or a transporter.

Abstract: The present invention provides small molecule activators of GIRK potassium channels and methods for use thereof.

Abstract: A humanized anti-EGFR antibody L4-H3 and gene encoding the antibody are disclosed. The antibody is composed of a heavy chain and a light chain. The amino acid sequence of the heavy chain variable region is shown as positions 1-145 of SEQ ID NO: 3, the heavy chain constant region is the heavy chain constant region of the human antibody IgG1, and the amino acid sequence of the light chain is shown as SEQ ID NO: 1.

Abstract: In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Abstract: A weed removal device having a handle and a frame through which a rod extends. The rod has a mechanical lock near one end that connects the rod mechanically to the frame, and a base portion near the opposite end. The base portion includes pins that extend into soil around the weed to grasp the weed, and a foot pedal on which the user rests his weight to drive portions of the device into the soil. A spring is compressed when the pins are driven into the soil and grasp the weed, and upon removal of the weed and a plug of soil the mechanical lock can release the spring to expand and thereby eject the weed and soil with force sufficient to propel the weed many feed into a receptacle.